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ChemicalBook >> CAS DataBase List >> LY 2606368

LY 2606368

LY 2606368 price.
  • $116 - $4175
  • Product name: LY 2606368
  • CAS: 1234015-52-1
  • MF: C18H19N7O2
  • MW: 365.39
  • EINECS:
  • MDL Number:MFCD25977016
  • Synonyms:LY 2606368;5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile LY2606368;5-[[5-[2-(3-Aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile;5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile;Prexasertib;LY 2606368;LY-2606368;PREXASERTIB;Prexasertib (LY2606368);CS-1453
Price30 Properties Safety Information Description
30 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
  • Usbiological
Package
  • 0.5mg
  • 500ug
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number5000DG
  • Product descriptionPrexasertib
  • Packaging1mg
  • Price$226
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number5000DG
  • Product descriptionPrexasertib
  • Packaging5mg
  • Price$640
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB8313
  • Product descriptionLY2606368HCl
  • Packaging5mg
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1088
  • Product descriptionLY2606368
  • Packaging5mg
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB8313
  • Product descriptionLY2606368HCl
  • Packaging25mg
  • Price$660
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1088
  • Product descriptionLY2606368
  • Packaging25mg
  • Price$660
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA161375
  • Product descriptionLY2606368
  • Packaging1mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA161375
  • Product descriptionLY2606368
  • Packaging2mg
  • Price$232
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA161375
  • Product descriptionLY2606368
  • Packaging5mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA161375
  • Product descriptionLY2606368
  • Packaging10mg
  • Price$610
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA161375
  • Product descriptionLY2606368
  • Packaging25mg
  • Price$1250
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21490
  • Product descriptionLY2606368 ≥98%
  • Packaging1mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21490
  • Product descriptionLY2606368 ≥98%
  • Packaging5mg
  • Price$486
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21490
  • Product descriptionLY2606368 ≥98%
  • Packaging10mg
  • Price$799
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21490
  • Product descriptionLY2606368 ≥98%
  • Packaging25mg
  • Price$1141
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2198
  • Product descriptionPrexasertib 98.22%
  • Packaging5mg
  • Price$160
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5000DG Prexasertib 1mg $226 2021-12-16 Buy
AK Scientific 5000DG Prexasertib 5mg $640 2021-12-16 Buy
ApexBio Technology B8313 LY2606368HCl 5mg $220 2021-12-16 Buy
ApexBio Technology B1088 LY2606368 5mg $220 2021-12-16 Buy
ApexBio Technology B8313 LY2606368HCl 25mg $660 2021-12-16 Buy
ApexBio Technology B1088 LY2606368 25mg $660 2021-12-16 Buy
Biosynth Carbosynth FA161375 LY2606368 1mg $145 2021-12-16 Buy
Biosynth Carbosynth FA161375 LY2606368 2mg $232 2021-12-16 Buy
Biosynth Carbosynth FA161375 LY2606368 5mg $420 2021-12-16 Buy
Biosynth Carbosynth FA161375 LY2606368 10mg $610 2021-12-16 Buy
Biosynth Carbosynth FA161375 LY2606368 25mg $1250 2021-12-16 Buy
Cayman Chemical 21490 LY2606368 ≥98% 1mg $116 2024-03-01 Buy
Cayman Chemical 21490 LY2606368 ≥98% 5mg $486 2024-03-01 Buy
Cayman Chemical 21490 LY2606368 ≥98% 10mg $799 2024-03-01 Buy
Cayman Chemical 21490 LY2606368 ≥98% 25mg $1141 2024-03-01 Buy
ChemScene CS-2198 Prexasertib 98.22% 5mg $160 2021-12-16 Buy
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Properties

Boiling point :608.5±55.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in DMSO
form :A crystalline solid
pka :11.89±0.10(Predicted)
color :Light yellow to brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of <13 nM in a viability study of multiple colorectal cancer cell lines. Inhibition of Chk1 causes double-strand DNA breakage in cells leading to an excessive cell damage burden and subsequent cell death. In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM. LY2606368, at 25 nM, also significantly induces apoptosis and inhibits colony formation in AGS and MKN1 gastric cancer cells.

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