LY3214996
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- ₹0
- Product name: LY3214996
- CAS: 1951483-29-6
- MF: C22H27N7O2S
- MW: 453.56
- EINECS:-0
- MDL Number:MFCD31544324
- Synonyms:LY3214996;6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one;CS-2495;4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-;Temuterkib;Temuterkib (LY3214996);LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK;LY-3214996 (LY3214996)
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Properties
Boiling point :711.5±70.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM)
Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM) form :A crystalline solid
pka :6.58±0.10(Predicted)
color :White to yellow
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM)
Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM) form :A crystalline solid
pka :6.58±0.10(Predicted)
color :White to yellow
Safety Information
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Description
LY3214996 is an inhibitor of ERK1 and ERK2 (IC50 = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.More related product prices
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