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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Abemaciclib

Abemaciclib

Abemaciclib Structure
  • ₹0
  • Product name: Abemaciclib
  • CAS: 1231929-97-7
  • MF: C27H32F2N8
  • MW: 506.59
  • EINECS:
  • MDL Number:MFCD22665744
  • Synonyms:Abemaciclib, >=98%;Abemaciclib;abemaciclib(CDK 4/6 inhibitor);Bemaciclib(LY2835219, abemaciclib);CDK4/6 dual inhibitor;LY 2835219 (free base);LY2835219 (free base);LY-2835219 (free base)
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :689.3±65.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :4°C, protect from light
solubility :insoluble in H2O; ≥4.83 mg/mL in DMSO with gentle warming and ultrasonic; ≥6.34 mg/mL in EtOH with gentle warming
form :solid
pka :7.69±0.10(Predicted)
color :Off-white to yellow
InChIKey :UZWDCWONPYILKI-UHFFFAOYSA-N
SMILES :C1(NC2=NC=C(CN3CCN(CC)CC3)C=C2)=NC=C(F)C(C2C=C3N(C(C)C)C(C)=NC3=C(F)C=2)=N1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P314 Get medical advice/attention if you feel unwell.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

Abemaciclib is a potent and selective inhibitor of cyclin-dependent kinases, CDK4 and CDK6, as a method to inhibit the proliferation of cancer cells.

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