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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Angiogenesis >HIF inhibitor >2-METHOXYESTRADIOL

2-METHOXYESTRADIOL

2-METHOXYESTRADIOL Structure
  • ₹5300 - ₹41773.68
  • Product name: 2-METHOXYESTRADIOL
  • CAS: 362-07-2
  • MF: C19H26O3
  • MW: 302.41
  • EINECS:263-807-9
  • MDL Number:MFCD00010489
  • Synonyms:2-METHOXYESTRADIOL \ INHIBITOR OF CELL P ROLIFERATION AND ANGIOGENESIS;2-METHOXY-OESTRADIOL-(17BETA),(13S,17S)-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL;2-Hydroxyestradiol 2-Methyl Ether;2-Methoxy-17b-estradiol;2-Methoxyestra-1,3,5(10)-triene-3,17b-diol;NSC 659853;Panzem;2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
7 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • 50MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberM2530
  • Product description2-Methoxy-β-estradiol min. 97.0 %
  • Packaging25MG
  • Price₹5300
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberM2530
  • Product description2-Methoxy-β-estradiol min. 97.0 %
  • Packaging100MG
  • Price₹6900
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM6383
  • Product description2-Methoxyestradiol powder
  • Packaging5MG
  • Price₹9049.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number454180
  • Product description2-Methoxyestradiol - CAS 362-07-2 - Calbiochem A natural metabolite of 17β-estradiol that is devoid of estrogenic activity.
  • Packaging10MG
  • Price₹9490
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM6383
  • Product description2-Methoxyestradiol powder
  • Packaging10MG
  • Price₹12914.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number454180
  • Product description2-Methoxyestradiol - CAS 362-07-2 - Calbiochem A natural metabolite of 17β-estradiol that is devoid of estrogenic activity.
  • Packaging50MG
  • Price₹32230
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM6383
  • Product description2-Methoxyestradiol powder
  • Packaging50MG
  • Price₹41773.68
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) M2530 2-Methoxy-β-estradiol min. 97.0 % 25MG ₹5300 2022-05-26 Buy
TCI Chemicals (India) M2530 2-Methoxy-β-estradiol min. 97.0 % 100MG ₹6900 2022-05-26 Buy
Sigma-Aldrich(India) M6383 2-Methoxyestradiol powder 5MG ₹9049.7 2022-06-14 Buy
Sigma-Aldrich(India) 454180 2-Methoxyestradiol - CAS 362-07-2 - Calbiochem A natural metabolite of 17β-estradiol that is devoid of estrogenic activity. 10MG ₹9490 2022-06-14 Buy
Sigma-Aldrich(India) M6383 2-Methoxyestradiol powder 10MG ₹12914.23 2022-06-14 Buy
Sigma-Aldrich(India) 454180 2-Methoxyestradiol - CAS 362-07-2 - Calbiochem A natural metabolite of 17β-estradiol that is devoid of estrogenic activity. 50MG ₹32230 2022-06-14 Buy
Sigma-Aldrich(India) M6383 2-Methoxyestradiol powder 50MG ₹41773.68 2022-06-14 Buy

Properties

Melting point :188-190°C
Boiling point :464.4±45.0 °C(Predicted)
Density :1.178±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Room Temperature
solubility :DMSO: 10 mg/mL
form :crystalline
pka :10.29±0.60(Predicted)
color :light yellow
λmax :286nm(EtOH)(lit.)
InChIKey :CQOQDQWUFQDJMK-SSTWWWIQSA-N
CAS DataBase Reference :362-07-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

2-methoxy Estradiol (2-ME2) is a natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. Administration of 2-hydroxy estradiol (2-HE2) to rats results in formation and clearance of 2-ME2 with t? values of 7.9 and 24.9 minutes, respectively. 2-ME2 exhibits no affinity for estrogen receptors. 2-ME2 has achieved considerable attention as an anti-cancer agent acting as an angiogenesis inhibitor via the HIF-1α pathway. The levels of COMT and 2-ME2 are significantly lower in women with severe pre-eclampsia.

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