Welcome to chemicalbook!
China english Japan Germany India
400-158-6606
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structured search
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
head sculpture My chemicalbook

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >protein tyrosine kinase >AP26113

AP26113

AP26113 Structure
  • ₹0
  • Product name: AP26113
  • CAS: 1197958-12-5
  • MF: C26H34ClN6O2P
  • MW: 529.01
  • EINECS:234-394-2
  • MDL Number:MFCD23704187
  • Synonyms:5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine;AP26113-ANALOG;(2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)ami;AP26113;AP26113/AP-26113;5-chloro-N2-(4-(4-(diMethylaMino)piperidin-1-yl)-2-Methoxy-5-Methylphenyl)-N4-(2-(diMethylphosphoryl)phenyl)pyriMidine-2,4-diaMine;5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-2,4-pyrimidinediamine;5-Chloro-N2-[4-[4-(diMethylaMino)-1-piperidinyl]-2-Methoxyphenyl]-N4-[2-(diMethylphosphinyl)phenyl]
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :737.6±70.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥26.45 mg/mL in DMSO; insoluble in H2O; ≥55.9 mg/mL in EtOH
form :solid
pka :9.27±0.20(Predicted)
color :White to off-white
CAS DataBase Reference :1197958-12-5

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively). It drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM.

More related product prices

NVP-TAE684 - TAE 684 Crizotinib ALK/IGF1R inhibitor 1256580-46-7 1097917-15-1 Ceritinib (LDK378) Vandetanib Afatinib (BIBW 2992) Lenvatinib Dacomitinib (PF299804) 1195765-45-7 WZ4002 Cabozantinib Selumetinib INCB28060 PF-06463922

Related product price

Suppliers and manufacturers

Hebei Yanxi Chemical Co., Ltd.
AP26113
₹0.00 /1kg
AP26113 CAS:1197958-12-5
shandong perfect biotechnology co.ltd
Brigatinib(ap26113)
₹0.00 /1g
Brigatinib(ap26113) CAS:1197958-12-5
career henan chemical co
AP26113
₹1.00 /1kg
AP26113 CAS:1197958-12-5
CLEARSYNTH LABS LTD.
Shanghai Daken Advanced Materials Co.,Ltd
ATK CHEMICAL COMPANY LIMITED
Chongqing Chemdad Co., Ltd
ENBRIDGE PHARMTECH CO., LTD.
Neostar United (Changzhou) Industrial Co., Ltd.
Shanghai UCHEM Inc.