Crizotinib
Crizotinib
- CAS:
- 877399-52-5
- MF:
- C21H22Cl2FN5O
- MW:
- 450.34
Suppliers by country/region
Company Type
Properties
- Melting point:
- 192 °C
- Boiling point:
- 599.2±50.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming)
- pka
- 9.81±0.10(Predicted)
- form
- powder
- color
- white to tan
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
- InChIKey
- KTEIFNKAUNYNJU-GFCCVEGCSA-N
- SMILES
- C1(N)=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@@H](C1=C(Cl)C=CC(F)=C1Cl)C
Safety Information
- Symbol(GHS)
GHS07,GHS08,GHS09
- Signal word
- Warning
- Hazard statements
- H317-H319-H341-H400
- Precautionary statements
- P201-P273-P280-P302+P352-P305+P351+P338-P308+P313
- Safety Statements
- 24/25
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Use
Crizotinib (Xalkori(R), Pfizer), approved in 2011, was the first approved inhibitor targeting anaplastic lymphoma kinase (ALK). ROS protooncogene 1-encoded kinase (ROS1) of the tyrosine kinase insulin receptor class and MET proto-oncogene-encoded kinase of the hepatocyte growth factor receptor (HGFR) class are other kinases targeted by crizotinib.When approved in 2011, crizotinib was the first drug specifically targeting NSCLC patients. However, resistance to crizotinib was usually observed in approximately 8 months after initial application and more than half of crizotinib-treated patients experienced gastrointestinal side effects. In 2016,crizotinib was additionally approved for ROS1-positive NSCLC by FDA.
19 India supplier list of "Crizotinib"
- Product Name:Crizotinib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Crizotinib
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Crizotinib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Crizotanib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Crizotinib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Crizotinib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Crizotinib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Crizotinib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Crizotinib
- Products Intro:Purity: 99% | Package: 1kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Crizotinib
- Products Intro:Brand:sigma aldrich | Product Number:PZ0191 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: INDIA