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ChemicalBook > Product Catalogue >Pharmaceutical intermediates >Bulk Drug Intermediates >(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Structure
  • ₹0
  • Product name: (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
  • CAS: 877397-65-4
  • MF: C8H7Cl2FO
  • MW: 209.04
  • EINECS:700-699-9
  • MDL Number:MFCD09863793
  • Synonyms:BenzeneMethanol,2,6-dichloro-3-fluoro-a-Methyl-, (aS)-;(1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(S)-1-(2,6-dichloro-4-fluorophenyl)ethanol;(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol;(aS)-2,6-Dichloro-3-fluoro-a-methyl-benzenemethanol;-1-(2,6-Dichloro-3-fluorophenyl);(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;JACS-877397-65-4
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :261.3±35.0 °C(Predicted)
Density :1.406±0.06 g/cm3(Predicted)
storage temp. :2-8°C
pka :13.30±0.20(Predicted)
form :Solid
color :White
InChI :InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/s3
InChIKey :JAOYKRSASYNDGH-UFLUHPNLNA-N
SMILES :[C@H](C1C(=CC=C(F)C=1Cl)Cl)(O)C |&1:0,r|
CAS DataBase Reference :877397-65-4

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.

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