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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Structure
CAS No.
877397-65-4
Chemical Name:
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
Synonyms
(S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(S)-1-(2,6-Dichloro-3-fluorophenyl)ethano;(S)-1-(2,6-DichL;JACS-877397-65-4;Crizotinib Interm 7654;-1-(2,6-Dichloro-3-fluorophenyl);(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;(S)-1-(2,6-dichloro-4-fluorophenyl)ethanol;(1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol
CBNumber:
CB11503932
Molecular Formula:
C8H7Cl2FO
Molecular Weight:
209.04
MOL File:
877397-65-4.mol
Modify Date:
2024/6/11 18:14:38
Request For Quotation

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Properties

Boiling point 261.3±35.0 °C(Predicted)
Density 1.406±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 13.30±0.20(Predicted)
form Solid
color White
InChI InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/s3
InChIKey JAOYKRSASYNDGH-UFLUHPNLNA-N
SMILES [C@H](C1C(=CC=C(F)C=1Cl)Cl)(O)C |&1:0,r|
CAS DataBase Reference 877397-65-4

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H317-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
HazardClass  IRRITANT
HS Code  2906290090
NFPA 704
1
2 0

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Chemical Properties,Uses,Production

Synthesis

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is synthesised using (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate as a raw material by chemical reaction. The specific synthesis steps are as follows:
Sodium methoxide (19 mmol; 0.5 M in methanol) was added slowly to compound S-2 (4.64 g, 18.8 mmol) under a nitrogen atmosphere at 0° C. The resulting mixture was stirred at room temperature for 4 hours. The solvent was evaporated and H2O (100 mL) was added. The cooled reaction mixture was neutralized with sodium acetate-acetic acid buffer solution to pH 7. Ethyl acetate (100 mL.x.2) was added to extract the aqueous solution. The combined organic layers were dried over Na2SO4, filtered, and evaporated to obtain S-1 as a white solid (4.36 g, 94.9percent yield); SFC-MS: 97percent ee. 1H NMR (400 MHz, chloroform-D) δ ppm 1.65 (d, J=6.8 Hz, 3 H) 5.58 (q, J=6.9 Hz, 1H) 6.96-7.10 (m, 1H) 7.22-7.36 (m, 1H).
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol synthesis

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Preparation Products And Raw materials

Raw materials

2,6-Dichloro-3-fluoroacetophenone (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

Preparation Products

(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-tert-butyloxycarbonylaminopyridine

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Suppliers

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Henan Fengda Chemical Co., Ltd 58
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BenzeneMethanol,2,6-dichloro-3-fluoro-a-Methyl-, (aS)- (1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol (S)-1-(2,6-dichloro-4-fluorophenyl)ethanol (1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol (aS)-2,6-Dichloro-3-fluoro-a-methyl-benzenemethanol -1-(2,6-Dichloro-3-fluorophenyl) (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol JACS-877397-65-4 (S)-1-(2,6-DichL Benzenemethanol, 2,6-dichloro-3-fluoro-α-methyl-, (αS)- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol ISO 9001：2015 REACH Crizotinib Interm 7654 (S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol (S)-1-(2,6-Dichloro-3-fluorophenyl)ethano (αS)-2,6-Dichloro-3-fluoro-α-methylbenzenemethanol (S)-l-(2,6-Dichl〇T〇-3 -fluorophenyl)ethanolethanol 877397-65-4 877399-65-4 Aromatic Ring Chiral Compounds