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(-)-Epigallocatechin gallate

CAS No.: 989-51-5

Chemical Name:: (-)-Epigallocatechin gallate

Synonyms: EGCG;EPIGALLOCATECHIN GALLATE;ECGC;(-)-Epigallocatechin-3-O-gallate (20 mg);epigallocatechin3-gallate;Epigallocatechin-3-Monogallate;(-)-epigallocatechin 3-gallate;E-5187;(EGCE);EGCG-d6

CBNumber:: CB2227188

Molecular Formula:: C22H18O11

Molecular Weight:: 458.37

MOL File:: 989-51-5.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:03

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(-)-Epigallocatechin gallate Properties

Melting point	222-224°C
alpha	D -185 ±2°(ethanol)
refractive index	-175.5 ° (C=1, EtOH)
storage temp.	2-8°C
solubility	H2O: ≥5mg/mL, clear
Boiling point	909.1±65.0 °C(Predicted)
Density	1.90±0.1 g/cm3(Predicted)
pka	7.75±0.25(Predicted)
form	Solid
color	White to Light Brown
Water Solubility	Soluble in ethanol, dimethyl formamide, water.
Merck	14,3526
Stability	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
InChIKey	WMBWREPUVVBILR-WIYYLYMNSA-N
LogP	0.639 (est)
CAS DataBase Reference	989-51-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H302-H317-H319-H411

Precautionary statements

P261-P273-P280-P301+P312-P302+P352-P305+P351+P338

Safety Statements

24/25

WGK Germany

RTECS

KB5200000

10-23

HS Code

29339900

Toxicity

LD50 oral in mouse: 2170mg/kg

NFPA 704

	0
2		0

(-)-Epigallocatechin gallate price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	PHR1333	Epigallocatechin gallate Pharmaceutical Secondary Standard; Certified Reference Material	989-51-5	1G	₹9818.28	2022-06-14	Buy
Sigma-Aldrich(India)	E4268	(−)-Epigallocatechin gallate ≥80% (HPLC), from green tea	989-51-5	100MG	₹8248.65	2022-06-14	Buy
Sigma-Aldrich(India)	E4143	(−)-Epigallocatechin gallate ≥95%	989-51-5	50MG	₹10348.7	2022-06-14	Buy
Sigma-Aldrich(India)	93894	(−)-Epigallocatechin gallate analytical standard	989-51-5	10MG	₹20784	2022-06-14	Buy
Sigma-Aldrich(India)	324880	(–)-Epigallocatechin Gallate - CAS 989-51-5 - Calbiochem One of the main polyphenolic constituents of green tea that exhibits potent antitumor, anti-inflammatory, and antioxidant properties.	989-51-5	10MG	₹7070	2022-06-14	Buy

Product number	Packaging	Price	Buy
PHR1333	1G	₹9818.28	Buy
E4268	100MG	₹8248.65	Buy
E4143	50MG	₹10348.7	Buy
93894	10MG	₹20784	Buy
324880	10MG	₹7070	Buy

(-)-Epigallocatechin gallate Chemical Properties,Uses,Production

Chemical Properties

solid

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Epigallocatechin gallate is a potent polyphenolic flavonoid which is found as a component of tea. It exhibits antioxidant, antimutagenic, antitumor and anti-inflammatory properties, thereby contributing to the health-beneficial actions. It finds potential use as a drug candidate in the pharmaceutical, cosmetic, and nutritional fields.

Hazard

Moderately toxic by ingestion.

Anticancer Research

EGCG and EGC are the active polyphenol compounds found in green tea, found toinhibit p-glycoprotein transport activities in Chinese hamster ovary (p-gp+) cells.EGCG facilitates the retraction of MDR phenotype by reducing cellular drug effluxwhen given in combination with vinblastine or doxorubicin. Hesperetin, quercetin,daidzein, silymarin, naringenin, and resveratrol also inhibit the MRP1, MRP4, andMRP5 (Kawasaki et al. 2008). Curcumin increases the cellular accumulation ofanticancer agents like cisplatin, tamoxifen, daunorubicin, vincristine, anddoxorubicin and thereby effectively sensitizes the drug-resistant cancer cells. Areduction in MDR1B expression in L1210/Adr cells (mouse leukemic MDR cells)by curcumin is mediated by PI3K, Akt, and NF-κB pathways. It also inhibits theABCG2 transporter activity. In addition curcumin facilitates the accumulation ofmitoxantrone and doxorubicin in ABCG2-expressing HEK cells and hence reversesMDR (Kawasaki et al. 2008; Dandawate et al. 2013).

(-)-Epigallocatechin gallate Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-Epigallocatechin gallate Suppliers

Global( 580)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Natural Remedies Pvt Ltd	+91 (80) 4020-9999	New Delhi, India	110	50	Inquiry
Otto Chemie Pvt. Ltd.	+91 9820041841	Mumbai, India	5873	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Alfa Aesar	1 800 209 7001	Maharashtra, India	6913	58	Inquiry
Natural Remedy Private Limited	09019202423	Karnataka, India	17	58	Inquiry
Maysar Herbals	08047629700	Haryana, India	19	58	Inquiry
Sigma Aldrich Chemicals Limited	08066219600	Karnataka, India	16	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
HiMedia Laboratories	91-22-61471919	Maharashtra, India	1843	58	Inquiry

Supplier	Advantage
Natural Remedies Pvt Ltd	50
Otto Chemie Pvt. Ltd.	58
TCI Chemicals (India) Pvt. Ltd.	58
Alfa Aesar	58
Natural Remedy Private Limited	58
Maysar Herbals	58
Sigma Aldrich Chemicals Limited	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
HiMedia Laboratories	58

Source and effects of EGCG
Phytochemicals are biologically active plant-derived compounds and are thought to be responsible for the health-promoting effe....
Mar 3，2022

(-)-Epigallocatechin gallate Spectrum

(-)-Epigallocatechin gallate(989-51-5)MS (-)-Epigallocatechin gallate(989-51-5)¹HNMR

989-51-5((-)-Epigallocatechin gallate)Related Search:

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(-)-EGCG-3'-O-ME (-)-EGCG-4'-O-ME (-)-EGCG-3''-O-ME (-)-EPIGALLOCATECHIN 3-(4''-O-METHYL)GALLATE (-)-Epigallocatechin gallate

OCTANICOTINOYL EPIGALLOCATECHIN GALLATE,OCTANICOTINOYL EPIGALLOCATECHIN GALLATE Epigallocatechin gallate solution,Epigallocatechin gallate solution GREEN TEA EXTRACT/ POLYPHENOL/ EPIGALLOCATECHIN GALLATE,GREEN TEA EXTRACT/ POLYPHENOL/ EPIGALLOCATECHIN GALLATE

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TEA CATECHIN EGCG, (-)-Epigallocatechin gallate/Green Tea EGCG90 EGCG, (-)-Epigallocatechin gallate/Green Tea Extract (-)-CIS-2-(3,4,5-TRIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3 ,5,7-TRIOL 3-GALLATE (-)-CIS-3,3',4',5,5',7-HEXAHYDROXY-FLAVANE-3-GALLATE L-Epigallocatechin Gallate (-)-Epigallocatechin Gallate-d6 3-O-Galloyl-(-)-epigallocatechin-d6 EGCG-d6 epi-Gallocatechin 3-O-Gallate-d6 epi-Gallocatechin Gallate-d6 Epigallocatechin-3-Monogallate-d6 L-Epigallocatechin Gallate-d6 (-)-cis-3,4-Dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1(2H)-benzopyran-3-yl Gallate EGCG Teatannin II EGCG, (-)-Epigallocatechin gallate/Green Tea EGCG95 3-(3,4,5-TRIHYDROXYBENZOATE) Benzoic acid, 3,4,5-trihydroxy-, (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester (-)-epigallocatechin-3-o-gallate (-)-epigallocatecholgallate 3-gallate,(-)-epigallocatecho Epigallocathecinfromgreentea EGCG (epigallocatechin gallate) EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 50% BY HPLC TEAVIGO(TM) EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 95% BY HPLC EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 30% BY HPLC EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 98% BY HPLC EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 70% BY HPLC EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 90% BY HPLC EGCG: E-5187(-)-EPIGALLOCATECHIN GALLATE Egcg90% EpigallocatechinGallate(Egcg) (-)-cis-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1(2h)-benzopyran-3-yl gallate (-)-epigallocatechin gallate from green tea EPIGALLOCATCCHINGALLATE [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 3,4,5-trihydroxybenzoate EPIGALLOCATECHIN GALLATE, (-)- SNAPN 0.1mg/mL(SH) EPIGALLOCATECHIN GALLATE, (-)-(P) EPIGALLOCATECHIN GALLATE, (-)-(SH) (-)-EPIGALLOCATECHIN GALLATE hplc (-)EPIGALLOCATECHIN GALLATE WITH HPLC Green tea extract/EGCG Benzoicacid, 3,4,5-trihydroxy-, 3,4-dihydro-5,7- dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-ylester,(2R-cis)- EGCG, (-)-cis-3,3μ,4μ,5,5μ,7-Hexahydroxy-flavane-3-gallate, (-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate (-)-Epigallocatechin gallate ,98% 3,4,5-Trihydroxybenzoic acid [(2R,3R)-3,4-dihydro-5,7-dihydroxy-2α-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3α-yl] ester (-)-Epigallocatehin gallate EGCG(Green Tea Extract) [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate 3,4,5-trihydroxybenzoic acid [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] ester epigallocathequin gallate ()-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-( ()-Epigallocatechin gallate,()-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate, ()-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate, EGCG 3-O-Galloyl-(-)-epigallocatechin Epigallocatechin 3-galla Teavigo Teavigo TG