o-Cresol
- CAS No.
- 95-48-7
- Chemical Name:
- o-Cresol
- Synonyms
- 2-METHYLPHENOL;Orthocresol;ortho-cresol;2-Cresol;Phenol,2-methyl-;o-Creso;ORTHO CRESO;2-HYDROXYTOLUENE;O-HYDROXYTOLUENE;1-Methyl-2-hydroxybenzene
- CBNumber:
- CB4854694
- Molecular Formula:
- C7H8O
- Molecular Weight:
- 108.14
- MOL File:
- 95-48-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/20 15:10:03
| Melting point | 29-31 °C (lit.) |
|---|---|
| Boiling point | 191 °C (lit.) |
| Density | 1.048 g/mL at 25 °C |
| vapor density | 3.72 (vs air) |
| vapor pressure | 0.3 mm Hg ( 20 °C) |
| FEMA | 3480 | O-CRESOL |
| refractive index | 1.5361 |
| Flash point | 178 °F |
| storage temp. | under inert gas |
| solubility | 20g/l |
| form | Liquid or Low Melting Solid |
| pka | 10.2(at 25℃) |
| color | white to brown |
| Odor | at 0.01 % in dipropylene glycol. musty phenolic plastic medicinal herbal leathery |
| PH | 4.8 (20g/l, H2O, 20℃) |
| explosive limit | 1.47%, 148°F |
| Odor Threshold | 0.00028ppm |
| Odor Type | phenolic |
| Water Solubility | 20 g/L (20 ºC) |
| Merck | 14,2579 |
| JECFA Number | 691 |
| BRN | 506917 |
| Henry's Law Constant | 0.34 at 5.25 °C, 0.61 at 10.00 °C, 1.57 at 20.00 °C, 2.33 at 25.00 °C (dynamic equilibrium system- GC, Feigenbrugel et al., 2004a) |
| Exposure limits | NIOSH REL: TWA 2.3 ppm (10 mg/m3), IDLH 250 ppm; OSHA PEL: TWA 5 ppm (22 mg/m3); ACGIH TLV: TWA for all isomers 5 ppm (adopted). |
| Dielectric constant | 5.8（-5℃） |
| Stability | Stable, but light and air sensitive. Combustible. Incompatible with oxidizing agents, bases. |
| InChIKey | QWVGKYWNOKOFNN-UHFFFAOYSA-N |
| LogP | 1.95 at 20℃ |
| CAS DataBase Reference | 95-48-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenol, 2-methyl-(95-48-7) |
| EPA Substance Registry System | o-Cresol (95-48-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311-H314-H411 | |||||||||
| Precautionary statements | P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 24/25-34-39/23/24/25-23/24/25 | |||||||||
| Safety Statements | 36/37/39-45-36/37 | |||||||||
| RIDADR | UN 3455 6.1/PG 2 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 2.3 ppm (10 mg/m3) | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | GO6300000 | |||||||||
| F | 8-23 | |||||||||
| Autoignition Temperature | 555 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29071200 | |||||||||
| Toxicity | LD50 orally in rats: 1.35 g/kg (Deichmann, Witherup) | |||||||||
| IDLA | 250 ppm | |||||||||
| NFPA 704 |
|
o-Cresol price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C85700 | o-Cresol ReagentPlus?, ≥99% | 95-48-7 | 5G | ₹2035.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W348007 | o-Cresol ≥99% | 95-48-7 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C85700 | o-Cresol ReagentPlus?, ≥99% | 95-48-7 | 100G | ₹2457.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W348007 | o-Cresol ≥99% | 95-48-7 | 1KG | ₹7231.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C85700 | o-Cresol ReagentPlus?, ≥99% | 95-48-7 | 500G | ₹5001.15 | 2022-06-14 | Buy |
o-Cresol Chemical Properties,Uses,Production
Chemical Properties
o-Cresol has a musty, phenolic aftertaste.
Physical properties
Colorless solid or liquid with a phenolic odor; darkens on exposure to air. An odor threshold concentration of 0.28 ppbv was reported by Nagata and Takeuchi (1990).
Occurrence
Reported in Acacial farnesiana, ylang-ylang oil (probably as p-cresyl acetate), jasmine absolute, orange oil from leaves, the essence from flowers of Lilium candidum, anise seed oil, the essence of Artemisia santolinoflia, and some sea algae. Also reported found in asparagus, peppermint oil, cheddar cheese, provolone cheese, butter, milk, lean fish, boiled egg, smoked pork, rum, Scotch whiskey, red wine, white wine, coffee and mango.Reported found in cinnamon, coffee, Oriental tobacco, rum, sherry, tea, tomato and whiskey.
Uses
o-Cresol is used as a disinfectant and solvent. Lysol disinfectant is a 50% (v/v) mixed-cresol isomer in a soap emulsion formed on mixing with water. Besides disinfection products at solutions of 1–5%, the cresols are used as degreasing compounds, paintbrush cleaners, and additives in lubricating oils. Cresols were previously widely used for disinfection of poultry houses, but this use was discontinued because of their toxicity; they cause respiratory problems and abdominal edema in young chicks. o-Cresol has been used in synthetic resins, explosives, petroleum, photographic, paint, and agricultural industries.
Uses
o-Cresol is used mostly as an intermediate for the production of pesticides, epoxy resins, dyes, and pharmaceuticals, but also as a component of disinfectants and cleaning agents. o-Cresol is readily biodegradable and has a low bioaccumulation or geoaccumulation potential. Antiseptics; disinfectants; solvent; insecticides; resins; flame-retardant plasticizers
Definition
ChEBI: A cresol that is phenol substituted by a methyl group at position 2. It is a minor urinary metabolite of toluene.
Production Methods
Approximately 60% of o-cresol is obtained from coal-tar and crude oil by using classical techniques such as distillation, stripping, and liquid–liquid extraction. The remaining 40% is obtained synthetically by the alkylation of phenol with methanol. The cresols (cresylic acids) are methyl phenols and generally appear as a mixture of isomers. o-Cresol is a 2-methyl derivative of phenol and is prepared from o-toluic acid or obtained from coal tar or petroleum. Crude cresol is obtained by distilling “gray phenic acid” at a temperature of ≈180–201°C. o-Cresol may be separated from the crude or purified mixture by repeated fractional distillation in vacuo. It can also be prepared synthetically by diazotization of the specific toluidine or by fusion of the corresponding toluenesulfonic acid with sodium hydroxide.
General Description
Colorless or yellow to brown-yellow or pinkish colored liquid with a phenol-like odor. Toxic by ingestion and/or skin absorption. May have a flash point between 100 and 199°F. Causes burns to skin, eyes and mucous membranes. Insoluble in water.
Air & Water Reactions
Sensitive to light and air. Insoluble in water.
Reactivity Profile
o-Cresol is incompatible with oxidizing agents and bases. Mixing o-Cresol with chlorosulfonic acid, nitric acid and oleum in a closed contained caused the temperature and pressure to increase.
Hazard
Questionable carcinogen.
Health Hazard
The chemical is rated as a very toxic compound with a probable oral lethal dose in humans of 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 70 kg (150 lb.) person. It is a strong dermal irritant and frequently causes dermatitis. Serious or fatal poisoning may result if large areas of skin are wet with cresol, o- and the substance is not removed immediately. Ingestion of even a small amount may cause paralysis and coma. It is corrosive to body tissues, with toxicity similar to phenol.
Fire Hazard
Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. o-Cresol may burn but does not ignite readily. Container may explode in heat of fire. Slight explosion and fire hazard in the form of vapor when exposed to heat or flame. When heated to decomposition, o-Cresol emits highly toxic fumes. Reacts violently with nitric acid, oleum, and chlorosulfonic acid. Hazardous polymerization may not occur.
Safety Profile
Poison by ingestion, inhalation, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by skin contact. A severe eye and skin irritant. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. Flammable when exposed to heat, flame, or oxidants. To fight fire, water may be used to blanket fire; foam, fog, mist, dry chemical. See also other cresol entries and PHENOL.
Potential Exposure
Cresol is used as a disinfectant and fumigant; as an ore flotation agent, and as an intermediate in the manufacture of chemicals, dyes, plastics, and antioxidants. A mixture of isomers is generally used; the concentrations of the components are determined by the source of the cresol.
Shipping
UN2076 Cresols, liquid, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. UN3455 Cresols, solid, Hazard class: 6.1; Labels: 6.1- Poisonous materials, 8-Corrosive material.
Purification Methods
It can be freed from m-and p-isomers by repeated fractional distillation, It crystallises from *benzene by addition of pet ether. It has been fractionallly crystallised by partial freezing of its melt. The 3,5-dinitrobenzoate (prepared with 3,5-dinitrobenzoyl chloride in dry pyridine, and recrystallised from EtOH or aqueous Me2CO) has m 138o. [Beilstein 6 IV 1940.]
Incompatibilities
Vapors may form explosive mixture with air. Incompatible with strong acids; oxidizers, alkalies, aliphatic amines; amides, chlorosulfonic acid; oleum. Decomposes on heating, producing strong acids and bases, causing fire and explosion hazard. Liquid attacks some plastics and rubber. Attacks many metals.
Waste Disposal
Wastewaters may be subjected to biological treatment. Concentrations may be further reduced by ozone treatment. High concentration wastes may be destroyed in special waste incinerators.
o-Cresol Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Evans Fine Chem | +91-9821340302 +91-9821340302 | Maharashtra, India | 286 | 58 | Inquiry |
| Deepak Novochem Technologies Ltd | +91-2066090244 +91-8888854344 | Mumbai, India | 17 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Dhara Industries | +91-9322395199 +91-9322395199 | Mumbai, India | 190 | 58 | Inquiry |
| Atul Ltd | +91-2362230000 +91-2362230000 | Gujarat, India | 26 | 58 | Inquiry |
| LANXESS India Pvt. Ltd. | +91-8356878763 +91-8356878763 | Maharashtra, India | 190 | 58 | Inquiry |
| Dr Prem's Molecules Pvt. Ltd. | +91 9825310038 | New Delhi, India | 547 | 50 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1681 | 43 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1996 | 38 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Evans Fine Chem | 58 |
| Deepak Novochem Technologies Ltd | 58 |
| JSK Chemicals | 58 |
| Dhara Industries | 58 |
| Atul Ltd | 58 |
| LANXESS India Pvt. Ltd. | 58 |
| Dr Prem's Molecules Pvt. Ltd. | 50 |
| ALPHA CHEMIKA | 43 |
| Scientific OEM | 38 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |