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4-Chloroanisole

4-Chloroanisole Structure
CAS No.
623-12-1
Chemical Name:
4-Chloroanisole
Synonyms
1-CHLORO-4-METHOXYBENZENE;P-CHLOROANISOLE;para-Chloroanisole;4-Methoxyphenyl chloride;4-Chloroanisol;p-chloroanisol;Chloro anisole;4-CHLOROANISOLE;3 4-Chloroanisole;Anisole, p-chloro-
CBNumber:
CB1312283
Molecular Formula:
C7H7ClO
Molecular Weight:
142.58
MOL File:
623-12-1.mol
MSDS File:
SDS
Modify Date:
2024/7/24 13:33:21

4-Chloroanisole Properties

Melting point ?18 °C (lit.)
Boiling point 198-202 °C (lit.)
Density 1.164 g/mL at 25 °C (lit.)
vapor pressure 1.08hPa at 25℃
refractive index n20/D 1.535(lit.)
Flash point 173 °F
storage temp. Sealed in dry,Room Temperature
form Liquid
color Clear colorless to yellow
Water Solubility immiscible
BRN 1858901
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
LogP 2.78 at 25℃
CAS DataBase Reference 623-12-1(CAS DataBase Reference)
NIST Chemistry Reference Benzene, 1-chloro-4-methoxy-(623-12-1)
EPA Substance Registry System Benzene, 1-chloro-4-methoxy- (623-12-1)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H227
Precautionary statements  P210e-P280a-P370+P378a-P501a-P210-P280-P403+P235-P501
Hazard Codes  Xn
Safety Statements  23-24/25
RIDADR  UN 2810
WGK Germany  3
TSCA  Yes
HS Code  29093090
NFPA 704
2
1 0

4-Chloroanisole price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 159069 4-Chloroanisole 99% 623-12-1 100G ₹5304.25 2022-06-14 Buy
Sigma-Aldrich(India) 159069 4-Chloroanisole 99% 623-12-1 25G ₹6419.23 2022-06-14 Buy
TCI Chemicals (India) C0122 4-Chloroanisole min. 98.0 % 623-12-1 25G ₹1900 2022-05-26 Buy
TCI Chemicals (India) C0122 4-Chloroanisole min. 98.0 % 623-12-1 500G ₹17400 2022-05-26 Buy
ottokemi C 1989 4-Chloro anisole+ 98% 623-12-1 25gm ₹3969 2022-05-26 Buy
Product number Packaging Price Buy
159069 100G ₹5304.25 Buy
159069 25G ₹6419.23 Buy
C0122 25G ₹1900 Buy
C0122 500G ₹17400 Buy
C 1989 25gm ₹3969 Buy

4-Chloroanisole Chemical Properties,Uses,Production

Chemical Properties

colourless liquid

Uses

4-Chloroanisole was found to react with Cu (II)-smectite forming a blue clay-organic complex. 4-Chloroanisole was chosen as the main test substrate for the optimisation studies as it is electronically deactivated and thus resistant to oxidative addition and consequently very reluctant to enter a catalytic manifold.

General Description

4-Chloroanisole is an electron-rich chloroarene. It undergoes Ullmann-type homocoupling catalyzed by in situ generated Pd colloids. Reaction of 4-chloroanisole with Cu(II)-smectite in n-hexane, carbon tetrachloride or dichloromethane has been studied. The nucleophilic photosubstitution reactions, photocyanation and photohydrolysis of 4-chloroanisole has been studied by time resolved spectroscopy.

Purification Methods

Wash the anisole with 10% (by volume) aqueous H2SO4 (three times), 10% aqueous KOH (three times), and then with water until neutral. Dry it (MgSO4), and fractionally distil it from CaH2 through a glass helices-packed column under reduced pressure. [Beilstein 16 IV 822.]

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