Artemether
- CAS No.
- 71963-77-4
- Chemical Name:
- Artemether
- Synonyms
- artMether;Artimether;ARTHEMETER;ArteMether (SM-224);SM-224;Gvither;ArteMos;ArtenaM;Falcidol;Artesian
- CBNumber:
- CB4248286
- Molecular Formula:
- C16H26O5
- Molecular Weight:
- 298.37
- MOL File:
- 71963-77-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/6 18:26:58
| Melting point | 86-88°C |
|---|---|
| alpha | D19.5 +171° (c = 2.59 in CHCl3) |
| Boiling point | 359.79°C (rough estimate) |
| Density | 1.0733 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | off-white to light brown |
| optical activity | [α]/D +155 to +175°, c = 0.5 in methanol |
| Merck | 14,815 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H242-H302 | |||||||||
| Precautionary statements | P210-P235-P280-P301+P312-P370+P378-P410 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KD4165000 | |||||||||
| HS Code | 29329930 | |||||||||
| Toxicity | LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu) | |||||||||
| NFPA 704 |
|
Artemether price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A9361 | Artemether ≥98% (HPLC) | 71963-77-4 | 5MG | ₹8724.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3423 | Artemether certified reference material, pharmaceutical secondary standard | 71963-77-4 | 200MG | ₹19863.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A9361 | Artemether ≥98% (HPLC) | 71963-77-4 | 25MG | ₹35365.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A2190 | Artemether | 71963-77-4 | 5G | ₹6100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A2190 | Artemether | 71963-77-4 | 25G | ₹15200 | 2022-05-26 | Buy |
Artemether Chemical Properties,Uses,Production
Description
Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.
Chemical Properties
White Solid
Uses
Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when
Definition
ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip rum malaria.
General Description
Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant.
Safety Profile
Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes.
Artemether Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Micro Orgo Chem | +91-91-022-24969510 +91-9082984052 | Mumbai, India | 66 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 461 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Calyx Chemicals and Pharmaceuticals Ltd | +919819317220 | Mumbai, India | 15 | 58 | Inquiry |
| Bajaj Healthcare Ltd | +91-2266177400 +91-2266177400 | Maharashtra, India | 86 | 58 | Inquiry |
| Ipca Laboratories Ltd | +91-2262105000 +91-2262105000 | Maharashtra, India | 61 | 58 | Inquiry |
| Souvin Pharmaceuticals Pvt Ltd | +91-8983015895 +91-8983015895 | Maharashtra, India | 9 | 58 | Inquiry |
| Topnotch Chemicals Pvt Ltd | +91-7021345177 +91-7498237456 | Maharashtra, India | 6 | 58 | Inquiry |
| Deccan Nutraceuticals Pvt. Ltd | +91-9822641298 +91-9822641298 | Mumbai, India | 18 | 58 | Inquiry |
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