Chlorphenamine maleate
- CAS No.
- 113-92-8
- Chemical Name:
- Chlorphenamine maleate
- Synonyms
- chlorphenamine;CHLORPHENAMINE MALEATE;CHLORTRIMETON;CHLOROPHENIRAMINE MALEATE;CHLORPHENIRAMINE BASE;Puermin;piriton;teldrin;Histadur;antagonate
- CBNumber:
- CB9142008
- Molecular Formula:
- C20H23ClN2O4
- Molecular Weight:
- 390.86
- MOL File:
- 113-92-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:40
| Melting point | 130-135 °C (lit.) |
|---|---|
| alpha | -1～+1°(D/20℃)(c=5,DMF) |
| Density | 1.1984 (rough estimate) |
| refractive index | 1.6800 (estimate) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, soluble in ethanol (96 per cent) |
| form | Solid |
| color | White to Almost white |
| Odor | odorless |
| PH | 4.0～5.5 (10g/l, 25℃) |
| Water Solubility | 1-5 g/100 mL at 21 ºC |
| Merck | 14,2180 |
| BCS Class | 3/1 |
| InChIKey | DBAKFASWICGISY-BTJKTKAUSA-N |
| LogP | 3.389 (est) |
| EPA Substance Registry System | Chlorpheniramine maleate (113-92-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | T,F | |||||||||
| Risk Statements | 25-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 36/37/39-45-36/37-16 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US6504000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Toxicity | LD50 orally in mice: 162 mg/kg (Smith) | |||||||||
| NFPA 704 |
|
Chlorphenamine maleate price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C3025 | (±)-Chlorpheniramine maleate salt ≥99% (perchloric acid titration) | 113-92-8 | 5G | ₹3767.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1016 | Chlorpheniramine Maleate Pharmaceutical Secondary Standard; Certified Reference Material | 113-92-8 | 500MG | ₹8465.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C3025 | (±)-Chlorpheniramine maleate salt ≥99% (perchloric acid titration) | 113-92-8 | 25G | ₹9948.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C3025 | (±)-Chlorpheniramine maleate salt ≥99% (perchloric acid titration) | 113-92-8 | 100G | ₹23122.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C-036 | Chlorpheniramine maleate salt solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 113-92-8 | 1ML | ₹2407.3 | 2022-06-14 | Buy |
Chlorphenamine maleate Chemical Properties,Uses,Production
Description
Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.
Chemical Properties
White Solid
Uses
(±)-Chlorpheniramine maleate salt has been used:
- as H1 receptor antagonist to determine the receptor function
- to block the effect of compound 48/80 on plasma IGF-I
- as a standard for fast sensing and determination by sequential injector coupled with potentiometer
General Description
Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.
Air & Water Reactions
Water soluble.
Reactivity Profile
A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Fire Hazard
Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.
Safety Profile
Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.
Chlorphenamine maleate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| THE MOLECULEZ | +91-7506703683 +91-7506703683 | Maharashtra, India | 79 | 58 | Inquiry |
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| Merix Laboratories Pvt Ltd | +91-7893336376 +91-7893336376 | Telangana, India | 50 | 58 | Inquiry |
| KARUNESH REMEDIES | +919998776849 | Gujarat, India | 18 | 58 | Inquiry |
| Ions Pharma | +912266707500 | Maharashtra, India | 89 | 58 | Inquiry |
| Malladi Drugs AND Pharmaceuticals Limited | +91-9004653310 +91-9003056437 | Tamil Nadu, India | 69 | 58 | Inquiry |
| Adani Wilmar Limited | +91-7383819375 +91-9099656790 | Gujarat, India | 34 | 58 | Inquiry |
| Supriya Lifescience Ltd | +91-9820804279 +91-9821266261 | Maharashtra, India | 27 | 58 | Inquiry |
| Venkatasai Life Sciences | +91-9908134868 +91-8008303069 | Hyderabad, India | 186 | 58 | Inquiry |
| Afton Pharma | +91-9712000202 +91-9712000202 | Gujarat, India | 63 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| THE MOLECULEZ | 58 |
| Frolic Pharmachem | 58 |
| Merix Laboratories Pvt Ltd | 58 |
| KARUNESH REMEDIES | 58 |
| Ions Pharma | 58 |
| Malladi Drugs AND Pharmaceuticals Limited | 58 |
| Adani Wilmar Limited | 58 |
| Supriya Lifescience Ltd | 58 |
| Venkatasai Life Sciences | 58 |
| Afton Pharma | 58 |
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