Esculetin
- CAS No.
- 305-01-1
- Chemical Name:
- Esculetin
- Synonyms
- 6,7-DIHYDROXYCOUMARIN;AESCULETIN;Synonym;6,7-Dihydroxy-2H-chromen-2-one;Esculeti;ESCULETIN;ESCULETOL;Nsc 26428;Esculatin;Asculetine
- CBNumber:
- CB1456020
- Molecular Formula:
- C9H6O4
- Molecular Weight:
- 178.14
- MOL File:
- 305-01-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/7 16:07:22
| Melting point | 271-273 °C(lit.) |
|---|---|
| Boiling point | 270.35°C (rough estimate) |
| Density | 1.3431 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | 2-8°C |
| solubility | Solubility Almost insoluble in boiling water, ether; soluble in hot ethanol, glacial acetic acid |
| form | powder |
| pka | 1.71(at 25℃) |
| color | Light yellow |
| PH Range | Weak blue uorescence (1.5) to strong blue uorescence (2.0) |
| Water Solubility | slightly soluble |
| Merck | 14,3697 |
| BRN | 152788 |
| Major Application | antiinflammatory, Herbicides, cosmetics, teeth whitening agent, antifungal, neurodegenerative andfungal, antibacterial, antiviral, treating drug-induced weight gain, neurodegenerative and blood coagulation disorders, cancer, amyloidosis, skin impairments and baldness |
| InChIKey | ILEDWLMCKZNDJK-UHFFFAOYSA-N |
| LogP | 0.980 (est) |
| CAS DataBase Reference | 305-01-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Coumarin, 6,7-dihydroxy-(305-01-1) |
| EPA Substance Registry System | Esculetin (305-01-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338-P261-P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GN6382500 | |||||||||
| HS Code | 29322090 | |||||||||
| NFPA 704 |
|
Esculetin price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 246573 | 6,7-Dihydroxycoumarin 98% | 305-01-1 | 1G | ₹2749.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 68923 | Esculetin analytical standard | 305-01-1 | 50MG | ₹5585.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 246573 | 6,7-Dihydroxycoumarin 98% | 305-01-1 | 5G | ₹11701.83 | 2022-06-14 | Buy |
| TCI Chemicals (India) | E1287 | Esculetin [Matrix for MALDI-TOF/MS] | 305-01-1 | 200MG | ₹2700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | E1287 | Esculetin [Matrix for MALDI-TOF/MS] | 305-01-1 | 1G | ₹7800 | 2022-05-26 | Buy |
Esculetin Chemical Properties,Uses,Production
Chemical Properties
YELLOWISH CRYSTALLINE POWDER
Uses
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
Definition
ChEBI: A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.
General Description
Esculetin is a derivative of coumarin, found in various plant species including Cichorium intybus (chicory), Bougainvillea spectabilis, Artemisia capillaris, etc and leaves of Citrus limonia (Rutaceae), Ceratostigma willmottianum, etc. It exhibits multiple pharmacological activities and is found to be a potent inhibitor of cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, catechol-O-methyl transferase, NADPH oxidase and xanthine oxidase enzymes.
Purification Methods
It forms prisms from AcOH, aqueous EtOH or aqueous MeOH, and provides leaflets on sublimation in a vacuum. [Kagan J Am Chem Soc 88 2617 1966, Marby et al. Phytochemistry 4 492 1965.] Esculin (the 6-glucoside) has m 215o(dec), [] D -41o (c 5, pyridine). [Beilstein 18 III/IV 1322, 18/3 V 202.]
Esculetin Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SVH BIOSCIENCES | +91-6303499280 +91-6303499280 | Hyderabad, India | 478 | 58 | Inquiry |
| chakrachem Lifesciences | +91 9902744663 | Hyderabad, India | 451 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Biosyn Research Chemicals | +91 9346022300/+91 9399339999 | Telangana, India | 1340 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | China | 2972 | 58 | Inquiry |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | China | 1000 | 58 | Inquiry |
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