1,3-Dihydroxyacetone
- CAS No.
- 96-26-4
- Chemical Name:
- 1,3-Dihydroxyacetone
- Synonyms
- DIHYDROXYACETONE;1,3-dihydroxypropan-2-one;Dihyxal;Glycerone;Ketochromin;1,3-Dihydroxypropanone;1,3-DIHYDROXY-2-PROPANONE;2-Propanone, 1,3-dihydroxy-;Otan;Aliphatic ketone
- CBNumber:
- CB6306814
- Molecular Formula:
- C3H6O3
- Molecular Weight:
- 90.08
- MOL File:
- 96-26-4.mol
- Modify Date:
- 2024/7/7 20:48:41
| Melting point | 75-80 °C |
|---|---|
| Boiling point | 107.25°C (rough estimate) |
| Density | 1.1385 (rough estimate) |
| vapor pressure | 0.002-0.33Pa at 20-50℃ |
| FEMA | 4033 | DIHYDROXYACETONE |
| refractive index | 1.4540 (estimate) |
| storage temp. | Store at +2°C to +8°C. |
| solubility | >112.4 mg/mL in DMSO; >5.09 mg/mL in EtOH with ultrasonic |
| pka | 12.45±0.10(Predicted) |
| form | powder |
| color | White |
| Odor | at 100.00 %. minty |
| Odor Type | minty |
| Water Solubility | >250 g/L (20 ºC) |
| JECFA Number | 1716 |
| Stability | Stable. Combustible. Hygroscopic. |
| LogP | -1.95 at 20℃ |
| Surface tension | 68.85mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 96-26-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Propanone, 1,3-dihydroxy-(96-26-4) |
| EPA Substance Registry System | 2-Propanone, 1,3-dihydroxy- (96-26-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H315-H335 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Safety Statements | 24/25 |
| HS Code | 29141900 |
| Toxicity | CHROMELIN ? DIHYDROXYACETONE ? 1,3DIHYDROXYACETONE ? 1,3-DIHYDROXYPROPANONE ? DIHYXAL ? NSC-24343 ? OTAN ? OXATONE ? SOLEAL ? 2PROPANONE, 1,3-DIHYDROXY- ? TRIULOSE ? VITICOLOR |
1,3-Dihydroxyacetone price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.20482 | Dihydroxyacetone for synthesis | 96-26-4 | 8204820025 | ₹2840.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20482 | Dihydroxyacetone for synthesis | 96-26-4 | 100G | ₹6450 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20482 | Dihydroxyacetone for synthesis | 96-26-4 | 250G | ₹14080 | 2022-06-14 | Buy |
1,3-Dihydroxyacetone Chemical Properties,Uses,Production
Chemical Properties
white powder
Occurrence
A derivative of naturally occurring starch
Uses
1,3-Dihydroxyacetone can be used as artificial tanning agent.
Preparation
1,3-dihydroxyacetone (DHA) is prepared by acetalization, oxidation, and hydrolysis of glycerol. Usually produced commercially from Bacillus macerans or Bacillus circulans fermentation of starch or starch hydrolysate
Definition
ChEBI: Dihydroxyacetone is a ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones. It has a role as a metabolite, an antifungal agent, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a ketotriose and a primary alpha-hydroxy ketone.
General Description
Dihydroxyacetone (DHA) is a browning ingredient widely used in cosmetics such as sunless tanning formulations. It participates in a chemical staining reaction called Milliard reaction in which it reacts with the amino groups of proteins to result in a mixture of high molecular weight pigments.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Safety Profile
Mutation data reported. When heated to decompositionit emits acrid smoke and irritating vapors.
Safety
Cells that were treated with 1,3-Dihydroxyacetone (DHA) showed dose- and time-dependent changes that included cytoplasmic budding, chromatin condensation, and cell detachment. There was a significant decrease in cell proliferation after 24 hours of DHA exposure. After exposure to a 5% DHA solution for 21 days, epidermal thickening and dermatitis of the skin were noted in laboratory animals. After 42 days of treatment with the same solution, hyperplastic and dyskeratotic changes and moderate inflammatory reactions were seen. Long-lasting topical tanning products contain the sugars DHA or erythrulose, which cause a "Maillard reaction" when contacting proteins in the outer layers of the stratum corneum and epidermis. This reaction happens when free amino acids from skin proteins combine with DHA in the stratum corneum. This combination creates the tanned appearance of skin. Results are generally seen within a few hours of application. UV light exposure is not needed to initiate this chemical reaction[1].
References
[1] Gallagher, Mary. “Exposureto Dihydroxyacetone in Sunless Tanning Products.”Journal of the Dermatology Nurses'Association 10(1): 11-17.
1,3-Dihydroxyacetone Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Bhausa Life Sciences | +91-8154986830 +91-8154986830 | Gujarat, India | 201 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Alliance Pharma | +91-9824141142 +91-9824141142 | Gujarat, India | 181 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| Syrohchem Laboratories Pvt Ltd | +91-7559397527 +91-9370522022 | Maharashtra, India | 18 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | China | 3002 | 58 | Inquiry |
| CD Chemical Group Limited | +8615986615575 | China | 20356 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Bhausa Life Sciences | 58 |
| JSK Chemicals | 58 |
| Alliance Pharma | 58 |
| Otto Chemie Pvt Ltd | 58 |
| Syrohchem Laboratories Pvt Ltd | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | 58 |
| CD Chemical Group Limited | 58 |
Related articles
- When DHA is applied on the skin surface
- 1,3-Dihydroxyacetone (DHA) is the main active ingredient in sunless tanning skin-care preparations and an essential precursor ....
- Jun 27，2024
- 1,3-Dihydroxyacetone: Biosynthesis and Detection Method
- 1,3-Dihydroxyacetone can be produced from glycerol by metabolic engineering, while electrochemiluminescence enables sensitive ....
- May 31，2024
96-26-4(1,3-Dihydroxyacetone)Related Search:
1of4
chevron_right