1,3-Dihydroxyacetone
- CAS No.
- 96-26-4
- Chemical Name:
- 1,3-Dihydroxyacetone
- Synonyms
- DIHYDROXYACETONE;1,3-dihydroxypropan-2-one;Dihyxal;Glycerone;Ketochromin;1,3-Dihydroxypropanone;1,3-DIHYDROXY-2-PROPANONE;2-Propanone, 1,3-dihydroxy-;Otan;Aliphatic ketone
- CBNumber:
- CB6306814
- Molecular Formula:
- C3H6O3
Lewis structure
- Molecular Weight:
- 90.08
- MDL Number:
- MFCD00004670
- MOL File:
- 96-26-4.mol
| Melting point | 75-80 °C |
|---|---|
| Boiling point | 107.25°C (rough estimate) |
| Density | 1.1385 (rough estimate) |
| vapor pressure | 0.002-0.33Pa at 20-50℃ |
| FEMA | 4033 | DIHYDROXYACETONE |
| refractive index | 1.4540 (estimate) |
| storage temp. | Store at +2°C to +8°C. |
| solubility | >112.4 mg/mL in DMSO; >5.09 mg/mL in EtOH with ultrasonic |
| form | powder |
| pka | 12.45±0.10(Predicted) |
| color | White |
| Odor | at 100.00 %. minty |
| PH | 4-6 (20°C, 50g/L in H2O) |
| Odor Type | minty |
| Water Solubility | >250 g/L (20 ºC) |
| JECFA Number | 1716 |
| Stability | Stable. Combustible. Hygroscopic. |
| LogP | -1.95 at 20℃ |
| Surface tension | 68.85mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 96-26-4(CAS DataBase Reference) |
| FDA 21 CFR | 73.1150; 73.2150 |
| Substances Added to Food (formerly EAFUS) | DIHYDROXYACETONE (MONOMER) |
| EWG's Food Scores | 1-4 |
| FDA UNII | O10DDW6JOO |
| NIST Chemistry Reference | 2-Propanone, 1,3-dihydroxy-(96-26-4) |
| EPA Substance Registry System | 2-Propanone, 1,3-dihydroxy- (96-26-4) |
| Cosmetics Info | Dihydroxyacetone |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H315-H335 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Safety Statements | 24/25 |
| HS Code | 29141900 |
| Hazardous Substances Data | 96-26-4(Hazardous Substances Data) |
| Toxicity | CHROMELIN ? DIHYDROXYACETONE ? 1,3DIHYDROXYACETONE ? 1,3-DIHYDROXYPROPANONE ? DIHYXAL ? NSC-24343 ? OTAN ? OXATONE ? SOLEAL ? 2PROPANONE, 1,3-DIHYDROXY- ? TRIULOSE ? VITICOLOR |
1,3-Dihydroxyacetone price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.20482 | Dihydroxyacetone for synthesis | 96-26-4 | 100G | $60.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.20482 | Dihydroxyacetone for synthesis | 96-26-4 | 250G | $128 | 2024-03-01 | Buy |
| Frontier Specialty Chemicals | JK368677 | Dihydroxyacetone 98% | 96-26-4 | 250g | $144 | 2021-12-16 | Buy |
| Matrix Scientific | 119322 | 1,3-Dihydroxyacetone 95+% | 96-26-4 | 500g | $178 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD07750 | 1,3-Dihydroxyacetone | 96-26-4 | 100g | $200 | 2021-12-16 | Buy |
1,3-Dihydroxyacetone Chemical Properties,Uses,Production
Chemical Properties
Dihydroxyacetone has a characteristic sweet, cooling aroma.
Chemical Properties
white powder
Occurrence
A derivative of naturally occurring starch
Uses
1,3-Dihydroxyacetone can be used as artificial tanning agent.
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Uses
1,3-Dihydroxyacetone (DHA) is a self-tanning agent used in cosmetics designed to provide a tanned appearance without the need for sun exposure. It is also a uV protector and a color additive. As a self-tanning agent, it reacts with amino acids found on the skin’s epidermal layer. Its effects last only a few days as the color it provides fades with the natural shedding of the stained cells. Reportedly, it works best on slightly acidic skin. DHA, when combined with lawsone, becomes an FDA Category I (approved) uV protectant. In 1973, the FDA declared that DHA is safe and suitable for use in cosmetics or drugs that are applied to color the skin, and has exempted it from color additive certification.
Application
1,3-Dihydroxyacetone (DHA) is a common cosmetic material and food additive, and is also a versatile building block for the organic synthesis of a variety of fine chemicals. DHA is believed to be involved in weight gain and fat loss, antioxidant activity, and endurance improvement, and provides a safe and effective treatment option for recurrent vitiligo. DHA has also been developed as a highly efficient electrochemiluminescent co-reactant with Ru(bpy)32+. It is approximately 25 times more efficient than the well-known co-reactant sodium oxalate. The high electrochemiluminescence efficiency allows for sensitive detection of DHA without any derivatization. The electrochemiluminescence method exhibits two linear electrochemiluminescence responses in the range of 5.0–500 μM and 500 μM–6.0 mM, with a detection limit of 1.79 μM.[2]
Definition
ChEBI: Dihydroxyacetone is a ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones. It has a role as a metabolite, an antifungal agent, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a ketotriose and a primary alpha-hydroxy ketone.
Preparation
1,3-dihydroxyacetone (DHA) is prepared by acetalization, oxidation, and hydrolysis of glycerol. Usually produced commercially from Bacillus macerans or Bacillus circulans fermentation of starch or starch hydrolysate
Taste threshold values
Reported to have a taste threshold value lower than that of sucrose with a detection level of 3.9 to 27 ppm and a recognition level of 11 to 52 ppm.
General Description
Dihydroxyacetone (DHA) is a browning ingredient widely used in cosmetics such as sunless tanning formulations. It participates in a chemical staining reaction called Milliard reaction in which it reacts with the amino groups of proteins to result in a mixture of high molecular weight pigments.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Safety Profile
Mutation data reported. When heated to decompositionit emits acrid smoke and irritating vapors.
Safety
Cells that were treated with 1,3-Dihydroxyacetone (DHA) showed dose- and time-dependent changes that included cytoplasmic budding, chromatin condensation, and cell detachment. There was a significant decrease in cell proliferation after 24 hours of DHA exposure. After exposure to a 5% DHA solution for 21 days, epidermal thickening and dermatitis of the skin were noted in laboratory animals. After 42 days of treatment with the same solution, hyperplastic and dyskeratotic changes and moderate inflammatory reactions were seen. Long-lasting topical tanning products contain the sugars DHA or erythrulose, which cause a "Maillard reaction" when contacting proteins in the outer layers of the stratum corneum and epidermis. This reaction happens when free amino acids from skin proteins combine with DHA in the stratum corneum. This combination creates the tanned appearance of skin. Results are generally seen within a few hours of application. UV light exposure is not needed to initiate this chemical reaction[1].
References
[1] Gallagher, Mary. “Exposureto Dihydroxyacetone in Sunless Tanning Products.”Journal of the Dermatology Nurses'Association 10(1): 11-17.
[2] JIANRUI SUN. Detection of 1,3-dihydroxyacetone by tris(2,2′-bipyridine)ruthenium(II) electrochemiluminescence[J]. Analytical and Bioanalytical Chemistry, 2018, 410 9: 2315-2320. DOI:10.1007/s00216-017-0833-5.
1,3-Dihydroxyacetone Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18137 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3005 | 58 |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | 3684455296@qq.com | China | 9300 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 +86-15350571055 | Sibel@chuanghaibio.com | China | 6086 | 58 |
| ZhenYiBio Technology Inc | +8615309206328 | alexxue@zhenyibio.com | China | 298 | 58 |
| Zhejiang Westep Trading Company | +86-18968686833 +86-18968686833 | pandastep77@163.com | China | 3 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531153977 | allison@yan-xi.com | China | 5854 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
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View Lastest Price from 1,3-Dihydroxyacetone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | 1,3-Dihydroxyacetone
96-26-4
|
US $0.00 / KG | 25KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-04-27 | 1,3-Dihydroxyacetone
96-26-4
|
US $500.00-300.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2025-04-27 | 1,3-Dihydroxyacetone
96-26-4
|
US $6.00 / kg | 1kg | 99% | 2000KG/Month | HebeiShuoshengImportandExportco.,Ltd |
-
- 1,3-Dihydroxyacetone
96-26-4
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 1,3-Dihydroxyacetone
96-26-4
- US $500.00-300.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 1,3-Dihydroxyacetone
96-26-4
- US $6.00 / kg
- 99%
- HebeiShuoshengImportandExportco.,Ltd