Triclosan
- CAS No.
- 3380-34-5
- Chemical Name:
- Triclosan
- Synonyms
- IRGASAN;ch3565;TROX-100;riclosan;TRICLOSAN;Yriclosan;TRICHLOSAN;Cloxifenol;ZilesanUW.;Ttriclosan
- CBNumber:
- CB6771432
- Molecular Formula:
- C12H7Cl3O2
- Molecular Weight:
- 289.54
- MOL File:
- 3380-34-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/24 17:31:20
| Melting point | 56-60 °C(lit.) |
|---|---|
| Boiling point | 290°C(lit.) |
| Density | 1.4214 (rough estimate) |
| vapor pressure | 0.001Pa at 25℃ |
| refractive index | 1.4521 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble12g/L at 20°C |
| pka | 7.9(at 25℃) |
| form | Solid |
| color | colorless or white |
| Water Solubility | Soluble in ethanol, methanol, diethyl ether and sodium hydroxide solution (1M). Slightly soluble in water. |
| Merck | 14,9657 |
| BRN | 2057142 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | XEFQLINVKFYRCS-UHFFFAOYSA-N |
| LogP | 4.9 at 20℃ |
| CAS DataBase Reference | 3380-34-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Triclosan(3380-34-5) |
| EPA Substance Registry System | Triclosan (3380-34-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H410 | |||||||||
| Precautionary statements | P264-P273-P280-P302+P352-P305+P351+P338-P332+P313 | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 36/38-50/53-36/37/38 | |||||||||
| Safety Statements | 26-39-46-60-61-24/25-22-36 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | KO1100000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29095000 | |||||||||
| Toxicity | LD50 orl-rat: 3700 mg/kg 26UZAB 6,245,68/70 | |||||||||
| NFPA 704 |
|
Triclosan price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1338 | Triclosan Pharmaceutical Secondary Standard; Certified Reference Material | 3380-34-5 | 1G | ₹8356.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 93453 | Triclosan certified reference material, TraceCERT? | 3380-34-5 | 100MG | ₹8573.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.16100 | 5-Chloro-2-(2,4-dichlorophenoxy)phenol for synthesis | 3380-34-5 | 25G | ₹11600.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 72779 | Triclosan 97.0-103.0% (active substance, GC) | 3380-34-5 | 5G | ₹3041.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 72779 | Triclosan 97.0-103.0% (active substance, GC) | 3380-34-5 | 25G | ₹6170.25 | 2022-06-14 | Buy |
Triclosan Chemical Properties,Uses,Production
Description
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis. It is effective against Gram-negative and Gram-positive bacteria, as well as against Mycobacteria. Triclosan is used in a variety of products, including antiseptic soaps, deodorants, and hand washes.
Chemical Properties
Solid
Uses
triclosan is a preservative considered to have a low sensitizing potential in leave-on preparations.
Indications
Triclosan is a broad-spectrum antimicrobial compound. It was originally used in soaps, antiperspirants, and cosmetic toiletries as a germicide. Today, triclosan is incorporated into toothpaste because of its wide spectrum of antimicrobial activities and low toxicity.
Definition
ChEBI: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodo ants as well as in household items such as plastic chopping boards, sports equipment and shoes.
General Description
Chemical structure: diphenyl ether derivative
Mechanism of action
Triclosan is active against a broad range of oral grampositive and gram-negative bacteria.The primary target of its antibacterial activity is the bacterial cell membrane. High concentrations cause membrane leakage and ultimately lysis of the bacterial cell. Effects at lower concentration are more subtle. Triclosan has been shown to bind to cell membrane targets and inhibit enzymes associated with the phosphotransferase and proton motive force systems.
Pharmacology
Triclosan is retained in dental plaque for at least 8 hours, which in addition to its broad antibacterial property could make it suitable for use as an antiplaque agent in oral care preparations. However, the compound is rapidly released from oral tissues, resulting in relatively poor antiplaque properties as assessed in clinical studies of plaque formation.This observation is further corroborated by a poor correlation between minimal inhibitory concentration values generated in vitro and clinical plaque inhibitory properties of triclosan. Improvement of substantivity was accomplished by incorporation of triclosan in a polyvinyl methyl ether maleic acid copolymer (PVM/MA, Gantrez). With the combination of PVM/MA copolymer and triclosan, the substantivity of the triclosan was increased to 12 hours in the oral cavity.
Clinical Use
Triclosan plus copolymer is available in toothpaste. Commercially available dentifrice concentrations contain 0.3% triclosan and 2.0% PVM/MA copolymer.
Side effects
Triclosan is a preservative used in health care and consumer products, including soaps, deodorants, mouthwashes, toothpastes, cosmetics, and topical medicaments. Ozkaya et al. described a case of suspected immune mediated Cou to triclosan. A 44-year-old female reported experiencing an immediate localized urticarial response after contact with numerous topical products. The use of a toothpaste had also resulted in swelling of her lips, tongue, and breathing difficulties. She also experienced lip swelling after kissing her husband who had used the same product and wheals involving her face after kissing friends on the cheek who had used certain topical products on their faces. The suspected products all contained triclosan 0.2%–0.5%. A severe localized urticarial reaction occurred with open testing to 2% triclosan within 15 minutes. No tests were performed to confirm an immunological mechanism; however, the authors suspected this to be the case because of a positive urticarial response to triclosan within 15 minutes, a history of angioedema to the triclosan-containing toothpaste, and because no immediate reactions were seen in five control subjects who were open tested to 2% triclosan.
Safety Profile
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.Mildly toxic by skin contact. Mutation data reported. Ahuman skin irritant. When heated to decomposition itemits toxic fumes of Clí.
Triclosan Preparation Products And Raw materials
Raw materials
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| SHIVAM INDUSTRIES | +91-9820823043 +91-9820823043 | Mumbai, India | 30 | 58 | Inquiry |
| Process Speciality Chemicals | +91-9102512481942 +91-9821474142 | Maharashtra, India | 26 | 58 | Inquiry |
| Murli Krishna Exports Pvt Ltd | +91-2225631595 +91-2225631594 | New Delhi, India | 185 | 58 | Inquiry |
| Unisynth Chemicals | +91-9820430673 +91-9820430673 | Maharashtra, India | 32 | 58 | Inquiry |
| Vani Pharma Labs Limited | +91-4023193245 +91-4023193245 | Hyderabad, India | 17 | 58 | Inquiry |
| Super Hygienic Chemicals | +91-9821095252 +91-9821095252 | Mumbai, India | 23 | 58 | Inquiry |
| DL INTRACHEM | +91-9375014678 +91-9099014678 | Gujarat, India | 55 | 58 | Inquiry |
| Triveni Interchem Private Limited | +91-02606618618 +91-7574814001 | Gujarat, India | 42 | 58 | Inquiry |
| Salicylates and Chemicals Pvt. Ltd. | +91-8879630551 +91-8898005838 | Maharashtra, India | 61 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
Related articles
- Antibacterial properties of triclosan
- The chemical name of triclosan is 5-chloro-2-(2',4'-dichlorophenoxy)phenol, the chemical formula is C12H7Cl3O2, and it is an o....
- Apr 20，2022
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