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ChemicalBook > Product Catalog >Biochemical Engineering >Saccharides >Disaccharides >Sucralose

Sucralose

Sucralose Structure
CAS No.
56038-13-2
Chemical Name:
Sucralose
Synonyms
TGS;ctopyranoside;loro-4-deoxy-;Sucralose 0.1;TRICHLOROSUCROSE;Sucralose in stock GMP Factory;4,1’,6’-trichloro-4,1’,6’-trideoxy-galacto-sucrose;E955;ucralose;SUCRALOSE
CBNumber:
CB9363034
Molecular Formula:
C12H19Cl3O8
Molecular Weight:
397.63
MOL File:
56038-13-2.mol
MSDS File:
SDS
Modify Date:
2024/5/23 8:54:24
Request For Quotation

Sucralose Properties

Melting point 115-1018°C
Boiling point 104-107 C
alpha D +68.2° (c = 1.1 in ethanol)
Density 1.375 g/cm
vapor pressure 0Pa at 25℃
storage temp. 2-8°C
form Powder
pka 12.52±0.70(Predicted)
color White
PH 6-8 (100g/l, H2O, 20°C)
Odor wh. cryst. powd., odorless, sweet taste
optical activity [α]/D 86.0±2.0°, c = 1 in H2O
Water Solubility Soluble in Water.
Merck 14,8880
BRN 3654410
Stability Hygroscopic
LogP -0.51 at 20℃
CAS DataBase Reference 56038-13-2(CAS DataBase Reference)
EPA Substance Registry System .alpha.-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl 4-chloro-4-deoxy- (56038-13-2)

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-24/25
WGK Germany  3
RTECS  LW5440140
HS Code  2932 14 00
Toxicity LD50 orally in Rabbit: > 10000 mg/kg

Sucralose price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1342 Sucralose Pharmaceutical Secondary Standard; Certified Reference Material 56038-13-2 500MG ₹8919.8 2022-06-14 Buy
Sigma-Aldrich(India) 90984 Sucralose analytical standard 56038-13-2 100MG ₹13780.23 2022-06-14 Buy
Sigma-Aldrich(India) 69293 Sucralose ≥98.0% (HPLC) 56038-13-2 100G ₹15956.05 2022-06-14 Buy
TCI Chemicals (India) S0839 Sucralose 56038-13-2 5G ₹2900 2022-05-26 Buy
TCI Chemicals (India) S0839 Sucralose 56038-13-2 25G ₹4200 2022-05-26 Buy
Product number Packaging Price Buy
PHR1342 500MG ₹8919.8 Buy
90984 100MG ₹13780.23 Buy
69293 100G ₹15956.05 Buy
S0839 5G ₹2900 Buy
S0839 25G ₹4200 Buy

Sucralose Chemical Properties,Uses,Production

Description

Sucralose is the only non-caloric sweetener made from sugar. It is in fact the latest non nutritive sweetener to have been approved by US FDA and other regulatory bodies and have hit the markets .
Sucralose is derived from sugar through a multi-step patented manufacturing process that selectively substitutes three atoms of chlorine for three hydroxyl groups on the sugar molecule. This change produces a sweetener that has no calories, yet is 600 times sweeter than sucrose, making it roughly twice as sweet as saccharin and four times as sweet as aspartame.

Chemical Properties

Sucralose is a white to off-white colored, free-flowing, crystalline powder.

History

Sucralose, 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl- 4-chloro-4-deoxy-α-D-galactopyranoside, is a trichloro-galactosucrose sweetener developed by the British sugar company Tate & Lyle during the 1970s (U.S. Pat. 4,343,934 (Aug. 10, 1982), M. R. Jenner and D. Waite (to Talres Development), (U.S. Pat. 4,362,869 (Dec. 7, 1982), M. R. Jenner and co-workers (to Talres Development), and (U.S. Pat. 4,435,440 (Mar. 6, 1984), L. Hough, S. P. Phadnis, and R. A. Khan (to Tate & Lyle). It was licensed to McNeil-PPC, Inc., a Johnson & Johnson subsidiary, in the United States until a new agreement took place in February, 2004. McNeil Nutritionals retained ownership of SPLENDA Brand and the right for its worldwide retail and food service business. Tate & Lyle became the sole manufacturer of SPLENDA Brand sucralose and owned the right for its worldwide ingredient sales.

Uses

Sucralose (1,6-dichloro-1,6-dideoxy-p-fructofuranosyl-4-chloro-oc- D-galactopyra- noside) is a nonnutritive sweetener based on sucrose. It is selectively chlorinated and the glycoside link between the two rings is resistant to hydrolysis by acid or enzymes, so it is not metabolized. It has 400 to 800 times the sweetness of sucrose, is very soluble in water, and is stable in heat. It can be used in food products that are baked or fried.
Sucralose is produced by the selective chlorination of the sucrose molecule using a patented process by Tate and LyIe that replaces the three hydroxyl groups (OH) with three chlorine (Cl) atoms.
This modified sugar is minimally absorbed by the body and passes out unchanged. It was approved for use in foods and beverages in 1999 in the United States.

Production Methods

Sucralose may be prepared by a variety of methods that involve the selective substitution of three sucrose hydroxyl groups by chlorine. Sucralose can also be synthesized by the reaction of sucrose (or an acetate) with thionyl chloride.

Definition

ChEBI: A disaccharide derivative consisting of 4-chloro-4-deoxy-alpha-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose units linked by a glycosidic bond.

General Description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Sucralose is a polar, chlorinated sugar synthesized from saccharose precursor. It is widely used as a sweetener in a number of food and beverage products.

Pharmaceutical Applications

Sucralose is used as a sweetening agent in beverages, foods, and pharmaceutical applications. It has a sweetening power approximately 300–1000 times that of sucrose and has no aftertaste. It has no nutritional value, is noncariogenic, does not promote dental caries, and produces no glycemic response.

Safety

Sucralose is generally regarded as a nontoxic and nonirritant material and is approved, in a number of countries, for use in food products. Following oral consumption, sucralose is mainly unabsorbed and is excreted in the feces.
The WHO has set an acceptable daily intake for sucralose of up to 15 mg/kg body-weight.
LD50 (mouse, oral): > 16 g/kg
LD50 (rat, oral): > 10 g/kg

storage

Sucralose is a relatively stable material. In aqueous solution, at highly acidic conditions (pH < 3), and at high temperatures (≤35℃), it is hydrolyzed to a limited extent, producing 4-chloro-4- deoxygalactose and 1,6-dichloro-1,6-dideoxyfructose. In food products, sucralose remains stable throughout extended storage periods, even at low pH. However, it is most stable at pH 5–6.
Sucralose should be stored in a well-closed container in a cool, dry place, at a temperature not exceeding 21℃. Sucralose, when heated at elevated temperatures, may break down with the release of carbon dioxide, carbon monoxide, and minor amounts of hydrogen chloride.

Regulatory Status

The FDA, in April 1998, approved sucralose for use as a tabletop sweetener and as an additive in a variety of food products. In the UK, sucralose was fully authorized for use in food products in 2005. It is also accepted for use in many other countries worldwide. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Sucralose Preparation Products And Raw materials

Raw materials

Sweetening agent Sucrose Raffinose β-Galactosidase Phosphorus pentachloride
Triphenylantimony Monoester Thionyl chloride D-GALACTOSE 1-[2-(2-AZIDOETHOXY)ETHOXYETHYL]-2,3,4,6-TETRA-O-ACETATE
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Preparation Products

Sucralose Suppliers

Global( 835)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Atul Intermediates +91-7940399111 +91-9825071644 Gujarat, India 24 58 Inquiry
Medi Pharma Drug House +919930911911 Mumbai, India 143 58 Inquiry
Dodhia Group +91-9619867345 +91-9619867345 Mumbai, India 129 58 Inquiry
HRV Global Life Sciences +91-9820219686 +91-9820219686 Telangana, India 379 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Prakash Chemicals Agencies +91-8511140657 Gujarat, India 106 58 Inquiry
BioPlus Life Sciences (V B Medicare Pvt Ltd) +91-8043508200 +91-8043508200 Karnataka, India 5 58 Inquiry
Gangwal Healthcare Pvt Ltd +91-9320779960 Maharashtra, India 51 58 Inquiry
BioPlus Life Sciences 91-80-28410158 Karnataka, India 1 58 Inquiry
CAD Pharma Inc. 91-80-41536439 Karnataka, India 123 58 Inquiry
Supplier Advantage
Atul Intermediates 58
Medi Pharma Drug House 58
Dodhia Group 58
HRV Global Life Sciences 58
Ralington Pharma 58
Prakash Chemicals Agencies 58
BioPlus Life Sciences (V B Medicare Pvt Ltd) 58
Gangwal Healthcare Pvt Ltd 58
BioPlus Life Sciences 58
CAD Pharma Inc. 58

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Sucralose Spectrum

Sucralose(56038-13-2)MS

56038-13-2(Sucralose)Related Search:

Neotame Aspartame Sodium benzoate Sweetening agent Glycyrrhizic acid
Alitame Acesulfame Saccharin D-tagatose Stevioside
Thaumatin Molasses Trichlormethiazide 1',6,6'-Trichloro Sucrose Sucralose 6-Acetate
2,3,3',4,4'-penta-O-acetylsucrose Sucralose EP Impurity D 2,3,6,3',4'-penta-O-acetylsucrose
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1-(1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl)-4-chloro-4-deoxy-alpha-D-galactopyranoside SUCRALOSE(P) Sucralose ,98% 1,6-dichloro-1,6-dideoxy-beta-d-fructofuranosyl4-chloro-4-deoxy-alpha-d-gala alpha-d-galactopyranoside,1,6-dichloro-1,6-dideoxy-beta-d-fructofuranosyl4-ch 1,6-DICHLORO-1,6-DIDEOXY-BETA-D-FRUCTOFURANOSYL-4-CHLORO-4-DEOXY-ALPHA-D-GALACOTOPYRANOSIDE 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactose SUCRALOSE 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside SUCRALOSE FCC (TRICHLOROGALACTOSUCROSE) SucraloseC12H19Cl3O8 Sucralose98%Min. Sucralose99% Steviosides90% Sucralose&Int. SPLENDA [R] .alpha.-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl 4-chloro-4-deoxy- trichlorogalactosucrose 4,16trichloro-4,16trideoxy pentagalactosucrose SUCRALOSE /4,1'',6'',-TRICHLORO-4,1'',6''TRIDEOXY-PENTAGALACTOSUCROSE SUCRALOSE(TRICHLOROSUCROSE) Sucralose 98.0-102.0% 4,1,6-TRICHLOROGALACTOSUCROSE (SUCRALOSE) 1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galacotopyranoside 1,6-Dichloro-1,6-Dideoxy-B-D-Fructofuranosyl-4-Chloro-4-Deoxy-A-D-Galacotopyranoside (2R,3R,4R,5R,6R)-2-{[(2S,3R,4R,5R)-2,5-Bis(chloromethyl)-3,4-dihydroxytetrahydro furan-2-yl]oxy}- α-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy- E955,Trichlorosucrose (2R,3R,4R,5R,6R)-2-{[(2S,3R,4R,5R)-2,5-Bis(chloromethyl)-3,4-dihydroxytetrahydrofuran-2-yl]oxy}-5-chloro-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol (Sucralose) E955, Trichlorosucrose, 1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside 4，1’，6’-trichloro-galactosucorose trichlorosucorose 1',4,6'-Trichloro-galacto-sucrose 1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactopyranoside (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxy-oxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxy-tetrahydrofuran-2-yl]oxy-5-chloro-6-methylol-tetrahydropyran-3,4-diol (2R,3R,4R,5R,6R)-2-((2R,3S,4S,5S)-2,5-Bis(Chloromethyl)-3,4-Dihydroxytetrahydrofuran-2-Yloxy)-5-Chloro-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4-Diol SUBERIC ACID(RG) E955 Sucralose,1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside, E955, Trichlorosucrose Sucralose (400 mg) Sucralose (400 mg)G1E3170.998mg/mg(ai) Sucralose, FCC Sucralose, NF 2-{[2,5-bis(chloroMethyl)-3,4-dihydroxyoxolan-2-yl]oxy}-5-chloro-6-(hydroxyMethyl)oxane-3,4-diol Sucralose (E955 Sucralose > Sucralose Standard Sucralose CRS a-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-b-D-fructofuranosyl4-chloro-4-deoxy- Sucralose USP/EP/BP High Quality and Purity Food Additive Sucralose Powder CAS:?56038-13-2 ucralose Sucralose (1623626) 1,6-dichloro-1 4,1',6'-trichlorogalactosucrose 4,1’,6’-trichloro-4,1’,6’-trideoxy-galacto-sucrose