Neotame
- CAS No.
- 165450-17-9
- Chemical Name:
- Neotame
- Synonyms
- NEOTAME (200 MG);Neotame USP/EP/BP;NEOTAME;Neutame.;Neotame,NTM;NEOTAME 165450-17-9;Sweet Additives Neotame;Methoxypropiophenone 121-97-1;Neotame Solution in Water, 100μg/mL;CAS 165450-17-9 Food Additive Sweeteners Neotame E961
- CBNumber:
- CB7500392
- Molecular Formula:
- C20H30N2O5
- Molecular Weight:
- 378.46
- MOL File:
- 165450-17-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:17
| Melting point | 83-85°C |
|---|---|
| alpha | D -54.84° (c = 1 in methanol); D20 -39.8° (c = 0.5 in water) |
| Boiling point | 565.3±50.0 °C(Predicted) |
| Density | 1.133±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Chloroform (Sparingly), Ethanol (Sparingly), Ethyl Acetate (Sparingly), Methanol |
| pka | pKa1 3.01; pKa2 8.02(at 25℃) |
| form | Solid |
| color | White to Off-White |
| optical activity | [α]/D -41.0±3.0°, c = 0.5 in H2O |
| BRN | 8352678 |
| Stability | Hygroscopic |
| InChI | InChI=1/C20H30N2O5/c1-20(2,3)10-11-21-15(13-17(23)24)18(25)22-16(19(26)27-4)12-14-8-6-5-7-9-14/h5-9,15-16,21H,10-13H2,1-4H3,(H,22,25)(H,23,24)/t15-,16-/s3 |
| InChIKey | HLIAVLHNDJUHFG-HOTGVXAUSA-N |
| SMILES | C(=O)([C@@H](NCCC(C)(C)C)CC(O)=O)N[C@@H](CC1=CC=CC=C1)C(OC)=O |&1:2,15,r| |
| LogP | 3.834 (est) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29242990 |
Neotame price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 49777 | Neotame analytical standard | 165450-17-9 | 100MG | ₹9601.78 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N1112 | Neotame | 165450-17-9 | 1G | ₹2400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N1112 | Neotame | 165450-17-9 | 5G | ₹5900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N1112 | Neotame | 165450-17-9 | 25G | ₹10800 | 2022-05-26 | Buy |
Neotame Chemical Properties,Uses,Production
Chemical Properties
Neotame occurs as an odorless, white to off-white powder. It has an intense sweet taste 7000–13 000 times sweeter than sucrose depending on the matrix.
Uses
Neotame is a high intensity sweetener and flavor enhancer for use in foods, except in meat and poultry. it is 7,000–13,000 times sweeter than sugar and has a clean, sweet taste. it is a derivative of the dipep- tide composed of amino acids, aspartic acid, and phenylalanine. it can be blended with nutritive sweeteners such as sucrose and high fructose corn syrup as well as with high intensity sweeteners such as aspartame and sucralose. uses include beverages, baked goods, desserts, cereals. it functions as a flavor enhancer in certain applica- tions and flavor systems, such as mint-flavored chewing gum.
Preparation
Neotame is manufactured by the reaction of aspartame and 3,3-dimethylbutyraldehyde, followed by purification, drying and milling
Production Methods
Neotame is manufactured by the reaction of aspartame and 3,3- dimethylbutyraldehyde, followed by purification, drying, and milling.
Definition
ChEBI: A dipeptide composed of N-(3,3-dimethylbutyl)-L-aspartic acid and methyl L-phenylalanate units joined by a peptide linkage.
benefits
Neotame is sweet. 7,000 to 13,000 times sweeter than sugar. It has no unwanted off-taste or aftertaste that many other sweeteners is burden with. Neotame does not contribute energy (0 kcal), does not affect blood sugar levels (glycaemic index GI is 0) and does not cause caries. Compared to aspartame, it is cheaper and has several food technology advantages.
Pharmaceutical Applications
Neotame is a water-soluble, nonnutritive, intense sweetening agent
used in beverages and foods. It is structurally related to aspartame
and is about 7000–13 000 times sweeter than sucrose, and about
30–60 times sweeter than aspartame, making it the sweetest
artificial sweetener available. Neotame is said to have a ‘clean’
sweet taste in contrast to the bitter, metallic aftertaste associated
with saccharin. Although neotame has approximately the same
caloric value as sucrose (1.2 kJ/g) the small quantities used to
achieve a desired level of sweetness in a formulation mean that it is
essentially nonnutritive.
Neotame may be used in sub-sweetening quantities as a flavor
enhancer, e.g. with mint or strawberry flavor.
Safety
Neotame is a nonnutritive intense sweetening agent used in
beverages and foods. Studies in animals and humans have shown
that neotame is a relatively nontoxic, nonteratogenic, and
noncarcinogenic substance. It is reported as safe for use during
pregnancy and lactation, and by children and persons with diabetes.
At least 30% of ingested neotame is rapidly absorbed. Neotame
is metabolized to de-esterified neotame and methanol, with
practically all neotame being eliminated from the body in the urine
and feces. Peak plasma concentrations of neotame are observed at approximately 30–60 minutes after ingestion. Human studies in
healthy and diabetic patients suggest that neotame is well-tolerated
at doses up to 1.5 mg/kg body-weight daily (the highest dose
studied). Following reviews of over 100 animal and human toxicity
studies the European Food Safety Authority and WHO have
established an acceptable daily intake for neotame at up to 2 mg/kg
body-weight.
Metabolism
In the body, neotame is broken down rapidly and completely. The residual products are de-esterified neotame (92 per cent) and methanol (8 per cent). 80 per cent have left the body the natural way within two days. The rest will follow. 64 per cent via faeces. The rest via urine. Nothing accumulates in the body.
storage
Neotame is stable in bakery products and pasteurized dairy
products.
The bulk material should be stored in a well-closed container, in
a cool, dry place; it is stable for up to 5 years at room temperature.
Regulatory Status
Accepted for use as a food additive in several countries including the USA, Mexico, Australia, and New Zealand. Approved for use in India in pharmaceutical preparations.
Neotame Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Gangwal Healthcare Pvt Ltd | +91-9320779960 | Maharashtra, India | 51 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Prakash Chemicals International Private Limited | 91-265-6126197 | New Delhi, India | 204 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Dharam Biotech Private Limited | 08048617130 | Mumbai, India | 5 | 58 | Inquiry |
| Devson Impex Private Limited (Head Office) | 08048977099 | Mumbai, India | 38 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Related articles
- Neotame: An Overview of the Next Generation Sweetener
- Neotame is approximately 7,000 to 13,000 times sweeter than sucrose, making it one of the most intense sweeteners available.
- May 21，2024
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