D-Phenylalanine
- CAS No.
- 673-06-3
- Chemical Name:
- D-Phenylalanine
- Synonyms
- PHENYLALANINE;d-phe;H-D-PHE-OH;D-Phe-OH;(R)-PHENYLALANINE;(R)-2-amino-3-phenylpropanoic acid;NSC 25005;nci-c60195;Endorphenyl;D-Phenylalanin
- CBNumber:
- CB9773699
- Molecular Formula:
- C9H11NO2
- Molecular Weight:
- 165.19
- MOL File:
- 673-06-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 17:33:06
| Melting point | 273-276 °C(lit.) |
|---|---|
| Boiling point | 293.03°C (rough estimate) |
| alpha | 33.5 º (c=2, H2O) |
| Density | 1.1603 (rough estimate) |
| refractive index | 34 ° (C=2, H2O) |
| storage temp. | Store at RT. |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Powder |
| pka | 2.2(at 25℃) |
| color | White to off-white |
| Water Solubility | 27 g/L (20 ºC) |
| Merck | 14,7271 |
| BRN | 2804068 |
| Stability | Stable. Incompatible with strong oxidizing agents, acids, bases. |
| InChIKey | COLNVLDHVKWLRT-MRVPVSSYSA-N |
| LogP | 0.235 (est) |
| CAS DataBase Reference | 673-06-3(CAS DataBase Reference) |
| EPA Substance Registry System | D-Phenylalanine (673-06-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 24/25-45-36/37/39-27-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AY7533000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29224995 | |||||||||
| Toxicity | TDLo orl-hmn: 500 mg/kg/5W-I:GIT JACTDZ 1(3),124,82 | |||||||||
| NFPA 704 |
|
D-Phenylalanine price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P1751 | D-Phenylalanine ≥98% (HPLC) | 673-06-3 | 5G | ₹1786.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P1751 | D-Phenylalanine ≥98% (HPLC) | 673-06-3 | 25G | ₹8454.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P1751 | D-Phenylalanine ≥98% (HPLC) | 673-06-3 | 100G | ₹24854.2 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P0135 | D-Phenylalanine | 673-06-3 | 5G | ₹2100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P0135 | D-Phenylalanine | 673-06-3 | 25G | ₹5300 | 2022-05-26 | Buy |
D-Phenylalanine Chemical Properties,Uses,Production
Description
D-Phenylalanine, also known as D-alpha-Amino-beta-phenylpropionic acid, is a kind of non-proteinogenic amino acid. The biological function of D-phenylalanine remains unclear. However, it has certain anti-depressant, analgesic activities and pharmacological activity at niacin receptor II. The mechanism action of its analgesic activity seems to originate from its inhibition of enkephalin degradation by the carboxypeptidase A. Enkephalins are part of your body’s natural pain relief system. When they are broken down by enkephalinase, this contributes to the sensation of pain. D-Phenylalanine is specifically thought to be beneficial for reducing feelings of chronic pain. D-phenylalanine has been used with mixed results to treat chronic pain, including pain caused by rheumatoid arthritis. The primary use of D-phenylalanine as a health supplement is the relief of discomfort.
Chemical Properties
White crystalline powder
Uses
D-Phenylalanine, the stereoisomer of L-Phenylalanine (P319415) has been used in the synthesis of Schaeffer’s acid analogues as important structures in tuberculostatic design. They exhibit the ability to inhibit Mycobacterium tuberculosis type II dehydroquinase.
Definition
ChEBI: D-phenylalanine is the D-enantiomer of phenylalanine. It is a phenylalanine and a D-alpha-amino acid. It is a conjugate base of a D-phenylalaninium. It is a conjugate acid of a D-phenylalaninate. It is an enantiomer of a L-phenylalanine. It is a tautomer of a D-phenylalanine zwitterion.
General Description
D-phenylalanine appears as needles or prisms.
Air & Water Reactions
Water soluble. Aqueous solutions are weakly acidic.
Reactivity Profile
D-alpha-Amino-beta-phenylpropionic acid may be light sensitive. D-alpha-Amino-beta-phenylpropionic acid reacts with strong oxidizing agents, acids and bases. . Act as weak acids in solution.
Fire Hazard
Flash point data for D-alpha-Amino-beta-phenylpropionic acid are not available, however D-alpha-Amino-beta-phenylpropionic acid is probably combustible.
Safety Profile
Mildly toxic by intraperitoneal route. Human systemic effects by ingestion: nausea, hypermotility, diarrhea. When heated to decomposition it emits toxic fumes of NOx.
References
https://www.alfa.com/en/catalog/A10572/
https://en.wikipedia.org/wiki/Phenylalanine
Christianson, D. W., et al. "Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A. " Journal of Biological Chemistry264.22(1989):12849-53.
D-Phenylalanine Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Advantage |
|---|---|
| SYNOVA CHEMICALS | 58 |
| AMINO ORGANICS | 58 |
| Dodhia Group | 58 |
| JSK Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Maas Pharma Chemicals | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
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