Prednisone
- CAS No.
- 53-03-2
- Chemical Name:
- Prednisone
- Synonyms
- Deltasone;MOPP;PREDNISON;Prednisone Micronised;Cortan;Orasone;Paracort;Bicortone;Servisone;Prednicen-M
- CBNumber:
- CB6716222
- Molecular Formula:
- C21H26O5
- Molecular Weight:
- 358.43
- MOL File:
- 53-03-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/22 17:12:53
| Melting point | 236-238 °C(lit.) |
|---|---|
| alpha | 169 º (c=0.5, dioxane) |
| Boiling point | 410.86°C (rough estimate) |
| Density | 1.1121 (rough estimate) |
| refractive index | 170 ° (C=0.5, Dioxane) |
| Flash point | >200℃ |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9). |
| pka | 12.36±0.60(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 115mg/L(25 ºC) |
| Merck | 7722 |
| BRN | 2065301 |
| BCS Class | 1? |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 53-03-2(CAS DataBase Reference) |
| IARC | 3 (Vol. 26, Sup 7) 1987 |
| NIST Chemistry Reference | Prednisone(53-03-2) |
| EPA Substance Registry System | Prednisone (53-03-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373 |
| Precautionary statements | P260 |
| Hazard Codes | Xn |
| Safety Statements | 36/37/39-45-26-16 |
Prednisone Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder.
Uses
Prednisone is used for the same indications as cortisone for inflammatory processes, allergies, and adrenal gland insufficiency; however, it is somewhat more active than cortisone and has less of an effect on mineral volume.
Definition
ChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.
Indications
Prednisone 2.5 to 7.5 mg, administered at night or dexamethasone 0.25 to 0.75 mg are useful in female patients, with severe acne unresponsive to conventional therapy, who suffer from adrenal gland overproduction of androgens such as congenital adrenal hyperplasia.
General Description
Prednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.
Air & Water Reactions
Very slightly water soluble .
Hazard
Questionable carcinogen.
Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.
Purification Methods
Crystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]
Prednisone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SynThink RESEARCH CHEMICALS | +91-8177860948 +91-8177860948 | Mumbai, India | 494 | 58 | Inquiry |
| Symbiotec Pharma Lab Pvt Ltd | +91-7316676406 +91-7316676405 | Madhya Pradesh, India | 71 | 58 | Inquiry |
| Orgamine Chemicals(I) Pvt Ltd | +91-9820080281 +91-9820080281 | Maharashtra, India | 451 | 58 | Inquiry |
| Synthink Research Chemicals | 09158051123 | Pune, India | 398 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| CLEANCHEM LABORATORIES LLP | +91 98921 69560 | New Delhi, India | 326 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt. ltd | +91 8550986868 | Maharashtra, India | 736 | 58 | Inquiry |
| Olympus Chemicals & Fertilizers | 08068441058Ext 121 | Maharashtra, India | 486 | 58 | Inquiry |
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