Prednisolone
- CAS No.
- 50-24-8
- Chemical Name:
- Prednisolone
- Synonyms
- Prednisolon;cortalone;delta-cortef;Prednisolone CRS;Hydrocortisone EP Impurity A;Prednisolone for system suitability CRS;deltaf;solone;steran;prednis
- CBNumber:
- CB4109000
- Molecular Formula:
- C21H28O5
- Molecular Weight:
- 360.45
- MOL File:
- 50-24-8.mol
- Modify Date:
- 2024/8/4 20:11:12
| Melting point | 240 °C (dec.) (lit.) |
|---|---|
| alpha | D25 +102° (dioxane) |
| Boiling point | 412.46°C (rough estimate) |
| Density | 1.0963 (rough estimate) |
| refractive index | 100 ° (C=1, Dioxane) |
| Flash point | 2℃ |
| storage temp. | 2-8°C |
| solubility | Very slightly soluble in water, soluble in ethanol (96 per cent) and in methanol, sparingly soluble in acetone, slightly soluble in methylene chloride. It shows polymorphism (5.9). |
| pka | 12.46±0.70(Predicted) |
| form | powder |
| color | White to Off-White |
| Water Solubility | 2.225g/L(25 ºC) |
| Merck | 14,7721 |
| BRN | 1354103 |
| BCS Class | 1 |
| InChIKey | OIGNJSKKLXVSLS-VWUMJDOOSA-N |
| CAS DataBase Reference | 50-24-8(CAS DataBase Reference) |
| EPA Substance Registry System | Prednisolone (50-24-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360FD | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | ||||||||||
| Toxicity | LD50 oral in mouse: 1680mg/kg | |||||||||
| NFPA 704 |
|
Prednisolone price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P6004 | Prednisolone ≥99% | 50-24-8 | 100MG | ₹1991.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P6004 | Prednisolone ≥99% | 50-24-8 | 1G | ₹4200.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P6004 | Prednisolone ≥99% | 50-24-8 | 5G | ₹15230.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P6004 | Prednisolone ≥99% | 50-24-8 | 10G | ₹26077.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1043 | Prednisolone Pharmaceutical Secondary Standard; Certified Reference Material | 50-24-8 | 500MG | ₹9493.53 | 2022-06-14 | Buy |
Prednisolone Chemical Properties,Uses,Production
Description
Prednisolone is the active metabolite of the synthetic corticosteroid prednisone , which is used in the suppression of inflammation and autoimmunity, as well as in other conditions. It alters gene expression through both the glucocorticoid and mineralocorticoid receptors.
Chemical Properties
Crystalline Solid. soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of prednisone in these solvents is approximately 3, 30, and 25 mg/ml, respectively.
Uses
Prednisolone is used for the same indications as all corticosteroids: rheumatism, polyarthritis, bronchial asthma, neurodermatitis, and eczema.
Definition
ChEBI: Prednisolone is a glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone. It has a role as an adrenergic agent, an anti-inflammatory drug, an antineoplastic agent, an immunosuppressive agent, a drug metabolite, an environmental contaminant and a xenobiotic. It is a glucocorticoid, an 11beta-hydroxy steroid, a 21-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone and a C21-steroid. It is functionally related to a Delta(1)-progesterone.
Application
Prednisolone is a synthetic corticosteroid with metabolically interconvertible with prednisone. It mediates its effect by acting on neurokinin 1 receptor. It is used to treat many conditions that cause inflammation, including inflammatory bowel disease (IBD).
General Description
Prednisolone,Δ1-hydrocortisone,11β,17,21-trihydroxypregna-1,4-diene-3,20-dione, hasless salt-retention activity than hydrocortisone, but some patients have more frequently experiencedcomplications such as gastric irritation and peptic ulcers.Because of low MC activity, it cannot be used alone for adrenalinsufficiency. Prednisolone is available in varioussalts and esters to maximize its therapeutic utility:
Prednisolone acetate, USP (21-acetate)
Prednisolone sodium phosphate, USP (21-sodiumphosphate)
Prednisolone sodium succinate, USP (21-sodiumsuccinate)
Prednisolone tebutate, USP (21-tebutate).
Hazard
Causes sodium retention; may have side effects similar to cortisone.
Mechanism of action
Prednisolone is hydrocortisone to which has been added a ?1 double bond. This places two double bonds in ring A, which flattens it and increases glucocorticoid action at the expense of mineralocorticoid activity. Prednisolone has fourfold the glucocorticoid activity of hydrocortisone while having approximately half its mineralocorticoid activity. In addition, prednisolone has an increased duration of action compared to hydrocortisone, because the extra double bond in ring A retards its metabolic reduction.
Clinical Use
Prednisolone can be used to treat severe asthmatic attacks that do not respond to conventional treatment, and it is available as the free alcohol for oral administration. The C-21 sodium phosphate (Hydeltrasol) ester is available for parenteral use.
Side effects
A prodrug of prednisolone is prednisone. It is the 11-keto analogue of prednisolone and must be converted in vivo to the active 11β-hydroxy compound, which is necessary to hydrogen bond to Asn-564 in the glucocorticoid receptor. Prednisone should not be used in patients with hepatic dysfunction, because their ability to reduce the 11-keto group with 11β-hydroxysteroid dehydrogenase to the active metabolite may be impaired.
Prednisolone is well tolerated by most people and can start to work very quickly. Side effects can be dependent on the dose and duration of treatment. Short courses of treatment often have fewer side effects than long term use. A Severe allergic reaction is a very rare side effect of prednisolone.
Safety Profile
A poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects by an unspecified route: developmental abnormalities of the central nervous system; effects on embryo or fetus: fetal death, extra embryonic structures. Human reproductive effects by an unspecified route: stdlbirth. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Prednisolone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SIMSON PHARMA LIMITED | +91-8291074273 | Shanghai, India | 228 | 58 | Inquiry |
| SynThink RESEARCH CHEMICALS | +91-8177860948 +91-8177860948 | Mumbai, India | 494 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Horster Biotek Pvt Ltd | +91-7359657360 +91-9898127219 | Gujarat, India | 58 | 58 | Inquiry |
| Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
| Envee Drugs Pvt Ltd | +91-02682559595 +91-8866665858 | Gujarat, India | 36 | 58 | Inquiry |
| Mahima Life Sciences Pvt Ltd | +91-9310406116 +91-9899984343 | New Delhi, India | 11 | 58 | Inquiry |
| Rioth Healthcare Private Limited | 91-22-28918746 | Maharashtra, India | 35 | 58 | Inquiry |
| CLEANCHEM LABORATORIES LLP | +91 98921 69560 | New Delhi, India | 326 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
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