프레드니솔원
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프레드니솔원 속성
- 녹는점
- 240 °C (dec.) (lit.)
- 알파
- D25 +102° (dioxane)
- 끓는 점
- 412.46°C (rough estimate)
- 밀도
- 1.0963 (rough estimate)
- 굴절률
- 100 ° (C=1, Dioxane)
- 인화점
- 2℃
- 저장 조건
- 2-8°C
- 용해도
- 물에 아주 약간 용해되고, 에탄올(96%)과 메탄올에 용해되며, 아세톤에는 약간 용해되고, 염화메틸렌에는 약간 용해됩니다. 다형성(5.9)을 보여줍니다.
- 산도 계수 (pKa)
- 12.46±0.70(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 2.225g/L(25℃)
- Merck
- 14,7721
- BRN
- 1354103
- BCS Class
- 1
- InChIKey
- OIGNJSKKLXVSLS-VWUMJDOOSA-N
- CAS 데이터베이스
- 50-24-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
위험품 표기 | |||
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유해 물질 데이터 | 50-24-8(Hazardous Substances Data) | ||
독성 | LD50 oral in mouse: 1680mg/kg | ||
기존화학 물질 | KE-34302 |
프레드니솔원 C화학적 특성, 용도, 생산
개요
Prednisolone is the active metabolite of the synthetic corticosteroid prednisone , which is used in the suppression of inflammation and autoimmunity, as well as in other conditions. It alters gene expression through both the glucocorticoid and mineralocorticoid receptors.화학적 성질
Crystalline Solid. soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of prednisone in these solvents is approximately 3, 30, and 25 mg/ml, respectively.용도
Prednisolone is used for the same indications as all corticosteroids: rheumatism, polyarthritis, bronchial asthma, neurodermatitis, and eczema.정의
ChEBI: Prednisolone is a glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone. It has a role as an adrenergic agent, an anti-inflammatory drug, an antineoplastic agent, an immunosuppressive agent, a drug metabolite, an environmental contaminant and a xenobiotic. It is a glucocorticoid, an 11beta-hydroxy steroid, a 21-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone and a C21-steroid. It is functionally related to a Delta(1)-progesterone.주요 응용
Prednisolone is a synthetic corticosteroid with metabolically interconvertible with prednisone. It mediates its effect by acting on neurokinin 1 receptor. It is used to treat many conditions that cause inflammation, including inflammatory bowel disease (IBD).일반 설명
Prednisolone,Δ1-hydrocortisone,11β,17,21-trihydroxypregna-1,4-diene-3,20-dione, hasless salt-retention activity than hydrocortisone, but some patients have more frequently experiencedcomplications such as gastric irritation and peptic ulcers.Because of low MC activity, it cannot be used alone for adrenalinsufficiency. Prednisolone is available in varioussalts and esters to maximize its therapeutic utility:Prednisolone acetate, USP (21-acetate)
Prednisolone sodium phosphate, USP (21-sodiumphosphate)
Prednisolone sodium succinate, USP (21-sodiumsuccinate)
Prednisolone tebutate, USP (21-tebutate).
위험도
Causes sodium retention; may have side effects similar to cortisone.Mechanism of action
Prednisolone is hydrocortisone to which has been added a ?1 double bond. This places two double bonds in ring A, which flattens it and increases glucocorticoid action at the expense of mineralocorticoid activity. Prednisolone has fourfold the glucocorticoid activity of hydrocortisone while having approximately half its mineralocorticoid activity. In addition, prednisolone has an increased duration of action compared to hydrocortisone, because the extra double bond in ring A retards its metabolic reduction.Clinical Use
Prednisolone can be used to treat severe asthmatic attacks that do not respond to conventional treatment, and it is available as the free alcohol for oral administration. The C-21 sodium phosphate (Hydeltrasol) ester is available for parenteral use.부작용
A prodrug of prednisolone is prednisone. It is the 11-keto analogue of prednisolone and must be converted in vivo to the active 11β-hydroxy compound, which is necessary to hydrogen bond to Asn-564 in the glucocorticoid receptor. Prednisone should not be used in patients with hepatic dysfunction, because their ability to reduce the 11-keto group with 11β-hydroxysteroid dehydrogenase to the active metabolite may be impaired.Prednisolone is well tolerated by most people and can start to work very quickly. Side effects can be dependent on the dose and duration of treatment. Short courses of treatment often have fewer side effects than long term use. A Severe allergic reaction is a very rare side effect of prednisolone.
Safety Profile
A poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects by an unspecified route: developmental abnormalities of the central nervous system; effects on embryo or fetus: fetal death, extra embryonic structures. Human reproductive effects by an unspecified route: stdlbirth. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.프레드니솔원 준비 용품 및 원자재
원자재
준비 용품
프레드니솔원 공급 업체
글로벌( 648)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9321 | 58 |
Pharmaceuticals Group Corp., Ltd. | +8613004379774 |
wu@jiaerke.com | China | 33 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3320 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5989 | 58 |
Hebei Kangcang new material Technology Co., LTD | +8615713292910 |
Nancy@kangcang.com.cn | China | 341 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9332 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
프레드니솔원 관련 검색:
프레드니손 히드로코르티손 아세트산 히드로코르티손 숙신산메틸프레드니졸론나트륨 프레드니무스틴 프레드니솔론-21-아세트산 프레드니솔원
PREDNISOLONE 21-PHOSPHATE, DISODIUM SALT,disodium prednisolone 21-phosphate,Prednisolone 21-sodium phosphate
Meprednisone
Hydrocortisone sodium succinate
Hydrocortisone-17-butyrate
Prednisone 21-acetate
Prednisolone sodium succinate
PARAMETHASONE ACETATE (200 MG)
prednylidene
Budesonide
Methylprednisolone
Fluprednisolone