히드로코르티손
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히드로코르티손 속성
- 녹는점
- 211-214 °C(lit.)
- 알파
- 166 º (c=1, C2H5OH 25 ºC)
- 끓는 점
- 414.06°C (rough estimate)
- 밀도
- 1.0812 (rough estimate)
- 굴절률
- 1.6120 (estimate)
- 인화점
- 220°C
- 저장 조건
- -20°C
- 용해도
- H2O: 100 mg/mL
- 물리적 상태
- 가루
- 색상
- 하얀색
- 수용성
- 319.7mg/L(25℃)
- 분해온도
- 220 ºC
- Merck
- 14,4787
- BRN
- 1354819
- 안정성
- 안정적이지만 빛에 민감할 수 있습니다. 강한 산화제와 호환되지 않습니다.
- LogP
- 1.610
- CAS 데이터베이스
- 50-23-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 62-63 | ||
안전지침서 | 36/37 | ||
WGK 독일 | 3 | ||
RTECS 번호 | GM8925000 | ||
TSCA | Yes | ||
HS 번호 | 29372100 | ||
유해 물질 데이터 | 50-23-7(Hazardous Substances Data) | ||
독성 | LD50 subcutaneous in mouse: > 500mg/kg | ||
기존화학 물질 | KE-34304 |
히드로코르티손 C화학적 특성, 용도, 생산
화학적 성질
crystalline white powder용도
Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.정의
ChEBI: A C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immun responsesIndications
Hydrocortisone (Cortizone, Cortaid, Anusol-HC, Hytone, LactiCare-HC, Sarnol HC, Penecort, Texacort, and many other branded products) may be purchased as a generic drug.일반 설명
Hydrocortisone, 11β,17,21-trihydroxypregn-4-ene-3,20-dione, is the primary natural GCin humans. Despite the large number of synthetic GCs, hydrocortisone,its esters, and its salts remain a mainstay ofmodern adrenocortical steroid therapy and the standard forcomparison of all other GCs and MCs . It isused for all the indications mentioned previously.건강위험
Cortisol Increases (1) protein catabolism (excepting liver) gluconeogenesis; (2) carbohydrate anabolism (liver); (3) blood sugar; (4) glucose absorption; (5) brain excitation; (6) spread of infections; (7)urinary glucose and nitrogen; (8) stress tolerance; (9) lactation; (10) water diuresis.Regulates general adaptation syndrome, water balance, blood pressure, and hormone release.
Decreases (1) fat anabolism; (2) growth rate; (3) inflammation; (4) eosinophils; (5) lymphocytes; (6) antigen sensitivity; (7) respiratory quotient; (8) ketosis; (9) wound healing; (10) skin pigmentation; (11)RBC hemolysis.
색상 색인 번호
Hydrocortisone is the principal glucocorticoid hor- mone produced by the adrenal cortex and is used topi- cally or systemically. It belongs to the allergenic A group. Marker of allergy is tixocortol pivalate.Mechanism of action
Hydrocortisone exhibits anti-shock, anti-allergy, and anti-inflammatory action. It raises sugar content in the blood, increases potassium secretion, and lowers sodium excretion from the body. It exhibits anti-metabolic action and reduces histamine synthesis in the body.Clinical Use
Hydrocortisone is endogenous, and it has both glucocorticoid and mineralocorticoid activity. It is the fundamental structure by which the glucocorticoid and mineralocorticoid activities of all other corticosteroids are judged. Functional groups that are essential for both mineralocorticoid and glucocorticoid activity include the pregnane skeleton with an all-trans backbone, the ring A-en-one system (?4 -3-one ring A) and the 17β-ketol side chain (C-20-keto-C-21-hydroxy). The glucocorticoid activity is enhanced by the C-11 and C-17 hydroxyl groups. Hydrocortisone can be used to treat severe asthmatic attacks that do not respond to conventional treatment. It is available as various ester forms.Safety Profile
Poison byPurification Methods
Recrystallise hydrocortisone from EtOH or isoPrOH. It is bitter tasting and has UV with max at 242 nm (log 4.20). Its solubility at 25o is: H2O (0.28%), EtOH (1.5%), MeOH (0.62%), Me2CO (0.93%), CHCl3 (0.16%), propylene glycol (1.3%) and Et2O (0.35%). It gives an intense green colour with conc H2SO4. [Wendler et al. J Am Chem Soc 72 5793 1950, Beilstein 8 IV 3422.]히드로코르티손 준비 용품 및 원자재
원자재
준비 용품
6,9-Difluoropregn-4-ene-11,17,21-triol-3,20-dione17,21-diacetate
9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione17,21-diacetate
9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
9-Fluoropregna-1,4-diene-11,17,21-triol-3,20-dione17,21-diacetate
6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate
6-Fluoro-17,21-dihydroxypregna-4,9(11)-diene-3,20-dione 17,21-diacetate
11alpha,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
9,11-Epoxy-6-fluoro-17,21-dihydroxypregn-4-ene-3,20-dione-17,21-diacetate
6alpha,9-difluoro-11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate
프레드니솔원
9,11-Epoxypregn-4-ene-17,21-diol-3,20-dione 21-acetate
17,21-디아세틸옥시-9,11-에폭시프레그n-4-엔-3,20-디온
Pregna-4,9(11)-diene-17,21-diol-3,20-dione17,21-diacetate
ANECORTAVE아세테이트(200MG)F0E2980.997MG/MG(AI)
Deprodone propionate
프레드니손
3,17,21-Trihydroxypregna-3,5,9(11)-trien-20-one 3,17,21-triacetate
히드로코르티손 아세트산
Hydrocortisone Butyrate Propionate
6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate)
9-fluoro-11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate
Triamcinolone 21-acetate
히드로코르티손 공급 업체
글로벌( 823)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 988 | 58 |
Wuhan Han Sheng New Material Technology Co.,Ltd | +8617798174412 |
admin01@hsnm.com.cn | China | 2118 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 295 | 58 |
Hebei Kangcang new material Technology Co., LTD | +8615713292910 |
Nancy@kangcang.com.cn | China | 341 | 58 |
Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 |
sales@suikangpharm.com | China | 311 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2989 | 55 |
히드로코르티손 관련 검색:
디에틸스틸베스트롤 히드로코르티손 아세트산 코르티존 프레드니손 프레드니솔원 프레드니솔론-21-아세트산 히드로코르티손
Hydrocortisone sodium phosphate
Hydrocortisone sodium succinate
Flurandrenolide
Hydrocortisone 21-hemisuccinate
Hydrocortisone-17-butyrate
Benazepril
hydrocortisone aceponate
5-Bromo-2,3-difluorophenol
D1-Hydrocortisone 21-hemisuccinate
Meprednisone
4-PREGNENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-CAPRYLATE