Flunisolide
- CAS No.
- 3385-03-3
- Chemical Name:
- Flunisolide
- Synonyms
- Nasarel;Nasalide;Flunisolide Hemihydrate;6-FLUORO-11,16ALPHA,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 16,17-ACETONIDE;Lunis;Nisolid;RS 3999;Synaclyn;Bronalide;Aerobid M
- CBNumber:
- CB4404835
- Molecular Formula:
- C24H31FO6
- Molecular Weight:
- 434.5
- MOL File:
- 3385-03-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:09
| Melting point | 237-240°C (dec.) |
|---|---|
| Boiling point | 581.8±50.0 °C(Predicted) |
| Density | 1.1517 (estimate) |
| storage temp. | Refrigerator |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:2): 0.2 mg/ml |
| form | A crystalline solid |
| pka | 12.87±0.10(Predicted) |
| color | White to off-white |
| Merck | 4145 |
| CAS DataBase Reference | 3385-03-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P301+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28 | |||||||||
| Safety Statements | 28-36/37-45 | |||||||||
| RIDADR | UN 2811 6.1 / PGI | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TU3900000 | |||||||||
| NFPA 704 |
|
Flunisolide Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Synthetic fluorinated corticosteroid related to Prednisolone (P703740). Antiasthmatic.
General Description
The portion of a flunisolide (AeroBid,Nasarel) dose that is swallowed is rapidly converted to the6β-hydroxy metabolite after first-pass metabolism in theliver. The 6β-hydroxy metabolite is approximately as activeas hydrocortisone itself, but the small amount produced usuallyhas limited systemic effects. Water-soluble conjugatesare inactive.
Clinical Use
Flunisolide is an acetone ketal (acetonide) with a 6α-fluoro group and a free C-21 hydroxyl group. The acetonide decreases mineralocorticoid activity, and the 6α-fluoro group increases glucocorticoid activity. It is not a prodrug, because it has the free hydroxyl group at C-21. Flunisolide has approximately 20% of the receptor affinity as budesonide, and approximately 40% of the inhaled dose is systemically bioavailable.
Metabolism
When administered intranasally or by inhalation, flunisolide is rapidly absorbed from nasal or lung tissue(94). This corticosteroid is efficiently metabolized by the liver to inactive metabolites with no apparent effects on adrenal function with long-term therapy. Flunisolide that is swallowed undergoes extensive first-pass metabolism in the liver, and that which is absorbed directly from the nasopharyngeal mucosa or lung bypasses this initial metabolism. It is not known if the drug undergoes metabolism in the GI tract. Flunisolide is rapidly hydroxylated by CYP3A4 at the 6β position, followed by elimination of the 6α-fluoro group to its more polar 6β-hydroxy metabolite, which attains plasma concentrations that usually are greater than those for flunisolide.
Flunisolide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Micro Orgo Chem | +91-91-022-24969510 +91-9082984052 | Mumbai, India | 66 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
3385-03-3(Flunisolide)Related Search:
1of4
chevron_right