Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Adrenal corticosteroids >11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Structure
CAS No.
13951-70-7
Chemical Name:
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Synonyms
16α-hydroxy-prednisolone;11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione;11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;16-ALPHA-HYDROXY PREDNISOLONE;11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione;16b;20-dione;4-diene-3;BNKY015-BD04
CBNumber:
CB7352308
Molecular Formula:
C21H28O6
Molecular Weight:
376.44
MOL File:
13951-70-7.mol
MSDS File:
SDS
Modify Date:
2024/3/19 9:29:41
Request For Quotation

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Properties

Melting point 235-238°C
Boiling point 591.5±50.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
vapor pressure 0Pa at 25℃
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly, Heated)
form Solid
pka 11.93±0.70(Predicted)
color White to Light Yellow
Water Solubility 815mg/L at 20℃
LogP 0.8 at 25℃
CAS DataBase Reference 13951-70-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361
Precautionary statements  P201-P202-P281-P308+P313-P405-P501

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Synthesis

501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

112,21-dihydroxypregna-1,4,16-triene-3,20-dione 16alpha-Hydroxyprednisonlone acetate

Preparation Products

Desonide

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Suppliers

Global( 342)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TRC FINE CHEMS +91-7400278327 +91-8097105248 Mumbai, India 73 58 Inquiry
OPULENT PHARMA +91-9106692785 +91-9106692785 Gujarat, India 479 58 Inquiry
CLEANCHEM LABORATORIES LLP +91-9951015911 +91-9951015911 Mumbai, India 281 58 Inquiry
SynThink RESEARCH CHEMICALS +91-8177860948 +91-8177860948 Mumbai, India 494 58 Inquiry
GLP Pharma Standards +91 9866074638 Hyderabad, India 1644 58 Inquiry
SYMBIOTEC PHARMALAB PRIVATE LTD +91-731-4200052 New Delhi, India 55 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Supplier Advantage
TRC FINE CHEMS 58
OPULENT PHARMA 58
CLEANCHEM LABORATORIES LLP 58
SynThink RESEARCH CHEMICALS 58
GLP Pharma Standards 58
SYMBIOTEC PHARMALAB PRIVATE LTD 58
CHEMSWORTH 30
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
SynZeal Research Pvt Ltd 58

13951-70-7(11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione)Related Search:

Budesonide Sulfate SodiuM (Mixture of DiastereoMers) 14,15-Dehydro Budesonide 9α-BroMobudesonide 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) Desonide
Budesonide Di-Norbudesonide (Mixture of DiastereoMers) 9,11-Anhydrobudesonide Budesonide EP Impurity D (Mixture of Diastereomers) 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione
(16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione 1,2-Dehydrobudesonide Budesonide Impurity 1 (Mixture of Diastereomers) Budesonide EP Impurity A-d4 Flunisolide
(r)-budesonide 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Ciclesonide
chevron_left

1of4

chevron_right
16A-HYDROXY-PREDNISONLONE 11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16 Alpha Hydroxprednisolone 16α-HYDROXY-PREDNISONLONE 11,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione Einecs 237-731-1 16A-HYDROXY-PREDNISOLONE 11a,16b,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione 11B,16A,17A,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 16a-Hydroxypredisolone (11β,16α)-11,16,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 16α-Hydroxyprednisolon Budesonide IMpurity A (16-alpha-Hydroxy-Prednisolone) (8S,9S,10R,13S,14S,16R,17S)-11,16,17-Trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one Prednisolone impurity 1/Prednisolone EP Impurity A/16-alpha-Hydroxy-Prednisolone/11?,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 9-[3-(1,2-dihydroxyheptyl)-2-oxiranyl]-9-hydroxynonanoic acid Budesonide iMpurit A Budesonide EP Impurity A (16-alpha-Hydroxy-Prednisolone) BNKY015-BD04 Budesonide EP Impurity A 16b 20-dione 21-Tetrahydroxy-pregna-1 4-diene-3 Budesonide impurity A Budesonide Impurity 1(Budesonide EP Impurity A) 11beta,16alpha,17,21-Tetrahydroxypr Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)- Desonide Impurity A 16α-hydroxy Prednisolone 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione USP/EP/BP Tmo Trimethylamine N-Oxide Dihydrate Powder 16α-hydroxy-prednisonlone 16 α Hydroxy PrednisoloneQ: What is 16 α Hydroxy Prednisolone Q: What is the CAS Number of 16 α Hydroxy Prednisolone Q: What is the storage condition of 16 α Hydroxy Prednisolone 16α-Hydroxyprednisolone-d5 11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione(triamcinolone) 11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione 16-ALPHA-HYDROXY PREDNISOLONE 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16α-hydroxy-prednisolone (8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one 16α-Hydroeyprednisolone Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)- 16α-Hydroxyprednisolone (Budesonide Impurity) 11β,16α,17α,21-Tetrahydroxypregnα-1,4-diene-3,20-dione Desonide EP Impurity-A 11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione 11β,16α,17α,21-tetrahydroxyprogesterone-1,4-diene-3,20-dione (8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one 13951-70-7 13952-70-7 Pharmaceutical Raw Materials Metabolites & Impurities Intermediates & Fine Chemicals Metabolites Pharmaceuticals Steroids