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ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Adrenal corticosteroids >11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Structure
CAS No.
13951-70-7
Chemical Name:
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Synonyms
16α-hydroxy-prednisolone;11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;16-ALPHA-HYDROXY PREDNISOLONE;11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione;16b;20-dione;4-diene-3;BNKY015-BD04;Einecs 237-731-1
CBNumber:
CB7352308
Molecular Formula:
C21H28O6
Molecular Weight:
376.44
MOL File:
13951-70-7.mol
MSDS File:
SDS
Modify Date:
2025/4/11 21:28:41
Request For Quotation

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Properties

Melting point 235-238°C
Boiling point 591.5±50.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
vapor pressure 0Pa at 25℃
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly, Heated)
form Solid
pka 11.93±0.70(Predicted)
color White to Light Yellow
Water Solubility 815mg/L at 20℃
LogP 0.8 at 25℃
CAS DataBase Reference 13951-70-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361
Precautionary statements  P201-P202-P281-P308+P313-P405-P501

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Synthesis

501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

112,21-dihydroxypregna-1,4,16-triene-3,20-dione 16alpha-Hydroxyprednisonlone acetate

Preparation Products

Desonide

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Suppliers

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13951-70-7(11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione)Related Search:

Budesonide Sulfate SodiuM (Mixture of DiastereoMers) 14,15-Dehydro Budesonide 9α-BroMobudesonide 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) Desonide
Budesonide Di-Norbudesonide (Mixture of DiastereoMers) 9,11-Anhydrobudesonide Budesonide EP Impurity D (Mixture of Diastereomers) 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione
(16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione 1,2-Dehydrobudesonide Budesonide Impurity 1 (Mixture of Diastereomers) Budesonide EP Impurity A-d4 Flunisolide
(r)-budesonide 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Ciclesonide
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16A-HYDROXY-PREDNISONLONE 11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16 Alpha Hydroxprednisolone 11,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione Einecs 237-731-1 16A-HYDROXY-PREDNISOLONE 11a,16b,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione 11B,16A,17A,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 16a-Hydroxypredisolone (11β,16α)-11,16,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 16α-Hydroxyprednisolon Budesonide IMpurity A (16-alpha-Hydroxy-Prednisolone) (8S,9S,10R,13S,14S,16R,17S)-11,16,17-Trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one Prednisolone impurity 1/Prednisolone EP Impurity A/16-alpha-Hydroxy-Prednisolone/11?,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 9-[3-(1,2-dihydroxyheptyl)-2-oxiranyl]-9-hydroxynonanoic acid Budesonide iMpurit A Budesonide EP Impurity A (16-alpha-Hydroxy-Prednisolone) BNKY015-BD04 Budesonide EP Impurity A 16b 20-dione 21-Tetrahydroxy-pregna-1 4-diene-3 Budesonide impurity A Budesonide Impurity 1(Budesonide EP Impurity A) 11beta,16alpha,17,21-Tetrahydroxypr Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)- Desonide Impurity A 16α-hydroxy Prednisolone 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione USP/EP/BP Tmo Trimethylamine N-Oxide Dihydrate Powder 16α-hydroxy-prednisonlone 16 α Hydroxy PrednisoloneQ: What is 16 α Hydroxy Prednisolone Q: What is the CAS Number of 16 α Hydroxy Prednisolone Q: What is the storage condition of 16 α Hydroxy Prednisolone 16α-Hydroxyprednisolone-d5 11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione(triamcinolone) 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione 16-ALPHA-HYDROXY PREDNISOLONE 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16α-hydroxy-prednisolone (8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one 16α-Hydroeyprednisolone 16α-Hydroxyprednisolone (Budesonide Impurity) 11β,16α,17α,21-Tetrahydroxypregnα-1,4-diene-3,20-dione 11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione 11β,16α,17α,21-tetrahydroxyprogesterone-1,4-diene-3,20-dione (8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one Desonide EP Impurity-A 16α-Hydroxyprednisolone/11β,16β,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione 11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione (16alpha-Hydroxyprednisolone) 16α-Hydroxyprednisolone, 10 mM in DMSO 11?,16a,17,21-Tetrahydroxypregna-1,4-dien-3,20-dione 11β,16α,17,21-Tetrahydroxypregna-1,4-dien-3,20-dione 11a'16b'17'21-Tetrahydroxy-pregna-1 13951-70-7 13952-70-7 Pharmaceutical Raw Materials Metabolites & Impurities Intermediates & Fine Chemicals