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Ciclesonide

Ciclesonide Structure
CAS No.
126544-47-6
Chemical Name:
Ciclesonide
Synonyms
Zetonna;Ciclesonide;Cyclosonide;Ciclesonide CRS;Alvesco, Ciclesonide;Ciclesonide(RPR251526);Ciclesonide containing impurity A CRS;(11β,16α)-16,17-[[(R)-CyclohexylMethylene]bis(oxy)]-11-hydroxy-21-(2-Methyl-1-oxopropoxy)-pregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione,16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-,(11b,16a)-;Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11β,16α)-
CBNumber:
CB3717420
Molecular Formula:
C32H44O7
Molecular Weight:
540.69
MOL File:
126544-47-6.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:06

Ciclesonide Properties

Melting point 202-209?C
Boiling point 665.0±55.0 °C(Predicted)
Density 1.23±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Chlorofrom (Slightly), Methanol (Slightly)
form Solid
pka 14.25±0.70(Predicted)
color White to Off-White
InChIKey LUKZNWIVRBCLON-GXOBDPJESA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361
Precautionary statements  P201-P202-P281-P308+P313-P405-P501

Ciclesonide Chemical Properties,Uses,Production

Chemical Properties

White Solid

General Description

Ciclesonide (Omnaris) is a prodrug that requireshydrolysis of the isobutyrate ester at C21 to form theactive corticosteroid (des-ciclesonide). It has minimal oralbioavailability due to extensive metabolism, mainly byCYP3A4. The metabolites of ciclesonide have not beenfully characterized.

Ciclesonide Preparation Products And Raw materials

Raw materials

Preparation Products

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Ciclesonide Spectrum

(r)-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde 21-isobutyrate Ciclesonide (11β,16α)-16,17-[[(R)-CyclohexylMethylene]bis(oxy)]-11-hydroxy-21-(2-Methyl-1-oxopropoxy)-pregna-1,4-diene-3,20-dione Ciclesonide(RPR251526) Ciclesonide containing impurity A CRS Ciclesonide CRS Zetonna Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11β,16α)- 2-[(6aR,6bS,7S,8aS,8bS,10R,11aR,12aS,12bS)-10-Cyclohexyl-7-hydroxy-6a,8a-dimethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl]-2-oxoethyl Isobutyrate Alvesco, Ciclesonide Pregna-1,4-diene-3,20-dione,16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-,(11b,16a)- (2′R)-2′-c yc loh e xyl-11β-h yd roxy-3,20-d i oxo-16βh -[1,3]d i oxolo[4′,5′:16,17]pre g na -1,4-d i e n-21-yl 2-me th ylpropa noa te Cyclosonide 126544-47-6 C33H46O7 C32H44O7 Other APIs Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Steroids