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Clonazepam

CAS No.: 1622-61-3

Chemical Name:: Clonazepam

Synonyms: Klonopin;Rivotril;5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2h-4-benzodiazepin-2-one;5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one;RO4023;Sentil;Landsen;Rivotri;Clonopin;ro4-8180

CBNumber:: CB1294954

Molecular Formula:: C15H10ClN3O3

Molecular Weight:: 315.71

MOL File:: 1622-61-3.mol

Modify Date:: 2023/4/23 13:52:06

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Clonazepam Properties

Melting point	236.5-238.50C
Boiling point	524.5±50.0 °C(Predicted)
Density	1.4592 (rough estimate)
refractive index	1.6470 (estimate)
Flash point	11 °C
storage temp.	2-8°C
solubility	Practically insoluble in water, slightly soluble in alcohol and in methanol.
pka	1.5, 10.5(at 25℃)
form	powder
color	light yellow
CAS DataBase Reference	1622-61-3(CAS DataBase Reference)
NIST Chemistry Reference	Clonazepam(1622-61-3)
EPA Substance Registry System	2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro- (1622-61-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS02,GHS06,GHS08
Signal word	Danger
Hazard statements	H225-H301+H311+H331-H370
Precautionary statements	P210-P260-P280-P301+P310-P311
Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25
Safety Statements	7-16-36/37-45-24/25-22
RIDADR	UN 1230 3/PG 2
WGK Germany	2
RTECS	DF2100000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2933910000
Toxicity	LD50 orally in mice: >4000 mg/kg (Blum)

Clonazepam Chemical Properties,Uses,Production

Description

Clonazepam (Item No. 14263) is an analytical reference material categorized as a benzodiazepine. Clonazepam is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.

Chemical Properties

Tan Solid

Uses

Antiepileptic agent with anxiolytic and antimanic properties. Anticonvulsant. This is a controlled substance (depressant)

Definition

ChEBI: 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus nd associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

brand name

Klonopin (Roche). Antelepsin (Arzneimittelwerk Dresden), Clonopin/ Rivotril (Roche).

General Description

Clonazepam is useful in absence seizures and in myoclonicseizures. Tolerance to the anticonvulsant effect of the clonazepamoften developed rather quickly, and it is a commonproblem with the BZDs. Metabolism involves hydroxylationof the C-3 position, followed by glucuronidation andnitro group reduction, followed by acetylation.

Hazard

Moderately toxic.

Clonazepam Preparation Products And Raw materials

Raw materials

2-BENZOYLACETANILIDE Benzophenone Copper(I) chloride Bromoacetyl bromide 2-Chlorobenzoyl chloride

Ammonia Pyridine Hydrogen 2-amino-2'-nitro-Benzophenone Sodium nitrite

Potassium nitrate

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Preparation Products

1622-61-3(Clonazepam)Related Search:

tert-Butylchlorodiphenylsilane TRIS(4-NITROPHENYL) PHOSPHATE 1-Chloro-3-nitrobenzene Triphenylmethyl Chloride 4-Chlorophenyl isocyanate

4,4'-DDT Benzophenone imine 1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one NITROGEN DIOXIDE N-METHYL-4-NITRO-O-TOLUIDINE

N1-(4-AMINO-2-METHYLPHENYL)ACETAMIDE Nitrazepam 4-Chloro-2-nitroaniline Meclonazepam 2-METHYL-4-NITROACETANILIDE

1,3-Dihydro-5-(2-chlorophenyl)-2H-1,4-benzodiozepin-2-one Triazolam Lorazepam

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Cloazepam clonazepam--deascheduleivitem Clonopin Iktorivil Landsen lktorivil Ro 4-8180 Ro 5-4023 Ro 5-4023/B-7 RO4023 ro4-8180 ro5-4023 5-(2-chlorophenyl)-7-nitro-1H-1,4-benzodiazepin-2(3H)-one Clonazepam (DD) clonazepam methanol solution 50(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one Rivotri CLONAZEPAM,USP 1-Pyrrolidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride Ribotril Sentil 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one Clonazepam,5-(2-Chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2(1H)-one Clonazepam CIV (200 mg)H0E0030.999mg/mg(ai) Methanol(test Clonazepam,1.0mg/mL) Clonazepam CIV (200 mg) ClonazepeM C1onazepaM 5-(2-Chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one Clonazepam solution CLONAZEPAM 5-[2-CHLOROPHENYL]-7-NITRO-3H-1,4-BENZODIAZEPIN-2[1H]-ONE 1,3-Dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one 2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro- 2H-1,4-Benzodiazepin-2-one, 5-(o-chlorophenyl)-1,3-dihydro-7-nitro- 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one 5-(o-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2-h-4-benzodiazepin-2-one 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2h-4-benzodiazepin-2-one 5-(o-chlorophenyl)-7-nitro-1h-1,4-benzodiazepin-2(3h)-one 7-nitro-5-(2-chlorophenyl)-3h-1,4-benzodiazepin-2(1h)-one antelepsin antilepsin Chlonazepam Clonazepam (CRM) Clonazepam Skype: honestcooperation Clonazepam USP/EP/BP ClonazepamQ: What is Clonazepam Q: What is the CAS Number of Clonazepam Q: What is the storage condition of Clonazepam Klonopin Rivotril 5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2h-4-benzodiazepin-2-one CLOZEPAM 1622-61-3 1662-61-3 C15H10ClN3O3 Amines Aromatics