4-Chlorophenyl isocyanate
- CAS No.
- 104-12-1
- Chemical Name:
- 4-Chlorophenyl isocyanate
- Synonyms
- 1-Chloro-4-isocyanatobenzene;P-CHLOROPHENYL ISOCYANATE;PCPI;4-Chlorphenylisocyanate;PARA CHLOROPHENYL ISOCYANATE;pcic;4-Chlorophenyl isocy;p-Chlorfenylisokyanat;4-Chlorphenylisocyanat;chlorophenylisocyanate
- CBNumber:
- CB6680525
- Molecular Formula:
- C7H4ClNO
- Molecular Weight:
- 153.57
- MOL File:
- 104-12-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/4 14:04:14
| Melting point | 26-29 °C (lit.) |
|---|---|
| Boiling point | 203-204 °C (lit.) |
| Density | 1.2 g/mL at 25 °C (lit.) |
| vapor pressure | 30Pa at 20℃ |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly) |
| form | Crystalline Solid |
| color | White to yellow |
| Odor | sharp irritating odor |
| Water Solubility | DECOMPOSES |
| Sensitive | Moisture Sensitive/Lachrymatory |
| BRN | 386235 |
| LogP | 3.12 at 22℃ |
| CAS DataBase Reference | 104-12-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-chloro-4-isocyanato-(104-12-1) |
| EPA Substance Registry System | p-Chlorophenyl isocyanate (104-12-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H318-H330-H334-H335-H410 | |||||||||
| Precautionary statements | P260-P273-P280-P302+P352-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T+,T,C | |||||||||
| Risk Statements | 25-26-37/38-41-42-52/53 | |||||||||
| Safety Statements | 23-26-28-36/37/39-45-61-38-37/39-28A-22 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NQ8575000 | |||||||||
| F | 10-19-21 | |||||||||
| Hazard Note | Toxic/Corrosive/Lachrymatory/Moisture Sensitive | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29291090 | |||||||||
| Toxicity | mammal (species unspecified),LC50,inhalation,53mg/m3 (53mg/m3),Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 11(4), Pg. 23, 1967. | |||||||||
| NFPA 704 |
|
4-Chlorophenyl isocyanate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 152277 | 4-Chlorophenyl isocyanate 98% | 104-12-1 | 5G | ₹1948.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 152277 | 4-Chlorophenyl isocyanate 98% | 104-12-1 | 100G | ₹3864.53 | 2022-06-14 | Buy |
| TCI Chemicals (India) | I0121 | 4-Chlorophenyl Isocyanate min. 98.0 % | 104-12-1 | 25G | ₹4600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | I0121 | 4-Chlorophenyl Isocyanate min. 98.0 % | 104-12-1 | 100G | ₹12600 | 2022-05-26 | Buy |
4-Chlorophenyl isocyanate Chemical Properties,Uses,Production
Chemical Properties
white to yellow crystalline solid
Uses
4-Chlorophenyl isocyanate is used in the preparation of isothiocyanates. Aryl isocyanates undergo [2+2] cycloaddition reactions with dihydrofuran to give bicyclic ?-lactams in high yield.
General Description
Colorless to yellow liquid or crystals. Used as an intermediate in pesticide and pharmaceutical manufacture.
Reactivity Profile
Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
Safety Profile
Poison by ingestion and inhalation. Unspecified human systemic effects. A severe eye and moderate skin irritant. A flammable liquid when exposed to heat or flame. Dangerous, can explode on distillation. When heated to decomposition it emits toxic fumes of Cl-, CN-, and NOx.
Purification Methods
Purify the isocyanate by recrystallisation from pet ether (b 30-40o) or better by fractional distillation. TOXIC irritant. [Beilstein 12 H 616, 12 III 1376, 12 IV 1213.]
4-Chlorophenyl isocyanate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SREE SYNERIC LAB | +91-91-6383636810 +91-9884742764 | Tamil Nadu, India | 465 | 58 | Inquiry |
| Paushak Limited | +91-2653007932 +91-9727736899 | Vadodara, India | 59 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| LANXESS India Pvt. Ltd. | +91-8356878763 +91-8356878763 | Maharashtra, India | 190 | 58 | Inquiry |
| S. Amit Speciality Chemicals Pvt. Ltd. | 91-22-40013003 | Maharashtra, India | 177 | 58 | Inquiry |
| LANXESS India Pvt. Ltd. | +91-22-2587 1000 | Maharashtra, India | 131 | 58 | Inquiry |
| SREE SYNERIC LAB | null | New Delhi, India | 328 | 58 | Inquiry |
| Paushak Ltd. (part of Alembic Group) | 91-265-3007932 | Gujarat, India | 12 | 58 | Inquiry |
| Amit Heterochem Labs (I) Limited | +91 522-4012318-20 | Uttar Pradesh, India | 12 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |