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Nitrazepam

CAS No.: 146-22-5

Chemical Name:: Nitrazepam

Synonyms: 1,3-dihydro-7-nitro-5-phenyl-2h-4-benzodiazepin-2-one;Ntz;Neozepam;Nitrazepam (CRM);1,3-dihydro-7-nitro-5-phenyl-1,4-benzodiazepin-2-one;7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one;7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one;la1;LA 1;Surem

CBNumber:: CB8338260

Molecular Formula:: C15H11N3O3

Molecular Weight:: 281.27

MOL File:: 146-22-5.mol

Modify Date:: 2025/1/27 9:38:02

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Nitrazepam Properties

Melting point	223-227?C
Boiling point	423.94°C (rough estimate)
Density	1.2309 (rough estimate)
refractive index	1.5700 (estimate)
Flash point	2℃
storage temp.	Controlled Substance, -20°C Freezer
solubility	Practically insoluble in water, slightly soluble in ethanol (96 per cent).
pka	pKa 2.90 ± 0.05;10.39±0.04(H2O,t =25,I=0.015(KCl))(Approximate)
Water Solubility	3.93mg/L(25 ºC)
CAS DataBase Reference	146-22-5(CAS DataBase Reference)
NIST Chemistry Reference	Nitrazepam(146-22-5)
EPA Substance Registry System	2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl- (146-22-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

3249

WGK Germany

RTECS

DF2450000

HazardClass

6.1(b)

PackingGroup

III

Toxicity

LD50 orally in rats: 825 ±80 mg/kg (Randall)

NFPA 704

	0
2		0

Nitrazepam Chemical Properties,Uses,Production

Chemical Properties

Pink Solid

Uses

Anticonvulsant; hypnotic. Controlled substance (depressant)

Definition

ChEBI: A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the trea ment of epileptic spasms in infants (West's syndrome).

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. An anticonvulsant and hypnotic agent. When heated to decomposition it emits toxic fumes of NOx. See also DIAZEPAM.

Nitrazepam Preparation Products And Raw materials

Raw materials

Chloroacetamide Chloroacetyl chloride 2-Amino-5-nitrobenzophenone 4-Chloroaniline Hexamethylenetetramine

Benzoyl chloride Nitric acid Glycine ethyl ester hydrochloride 2-Aminobenzophenone Acetamide, 2-amino-N-(2-benzoyl-4-nitrophenyl)-

1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one N-(2-benzoyl-4-nitrophenyl)-2-chloroacetamide p-Toluenesulfonic acid

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Preparation Products

Nitrazepam Spectrum

Nitrazepam(146-22-5)MS Nitrazepam(146-22-5)¹HNMR Nitrazepam(146-22-5)¹³CNMR Nitrazepam(146-22-5)IR1 Nitrazepam(146-22-5)IR2

146-22-5(Nitrazepam)Related Search:

Diphenyl ether Phenyl salicylate PHENYL VALERATE DIAZOXIDE Fentin hydroxide

PHENYL RESIN NITROUS OXIDE Phenylacetic acid Clonazepam FLUNITRAZEPAM

NITROGEN DIOXIDE Meclonazepam Nitrazepam, methylated Nitrazepam 3-hydroxyflunitrazepam

FLUNITRAZEPAM-(N-METHYL-D3) N-DESMETHYLFLUNITRAZEPAM N-DESMETHYLFLUNITRAZEPAM-D4

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Magadon Megadon Mogadan Mogadon Mogadone Sonebon Sonebon Tofraniln A Sonnolin Surem Trazenin Unisomnia NITRAZEPAM 1,3-DIHYDRO-7-NITRO-5-PHENYL-1,4-BENZODIAZEAN-2-ONE Quill 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one Nitrazepam, 99+% nitrazepam - Controlled drug - Schedule 4 Acetonitrile (test Nitrazepam,1.0mg/mL) nitrazepam--dea schedule iv item Nelbon Nelmat Neuchlonic Nitrados Nitravet nitrazepammethanolsolution Nitrazepan Nitrempax Nitrenpax Noctesed NSC-58775 Pacisyn Paxisyn Pelson Radedorm Relact Remnos Ro 4-5360 Ro 5-3059 Ro 53-60 ro4-5360 ro5-3059 S 2000 Somitran Somnased Somnibel Somnite Nitrazepam solution Calsmin Cerson Dormin-5 Dumolid Eatan Epibenzalin Epinelbon Eunoctin Eunoktin Hipnax Hipsal