Lorazepam
- CAS No.
- 846-49-1
- Chemical Name:
- Lorazepam
- Synonyms
- ATIVAN;(±)-Lorazepam solution;Lorazepam CIV (200 mg)I1D4040.998mg/mg(ai);7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one;Quait;Tavor;Wypax;LORAX;Wy-403;8133 CB
- CBNumber:
- CB9393402
- Molecular Formula:
- C15H10Cl2N2O2
- Molecular Weight:
- 321.16
- MOL File:
- 846-49-1.mol
- Modify Date:
- 2023/6/8 9:03:07
Melting point | 166-168°C |
---|---|
Boiling point | 533.8±50.0 °C(Predicted) |
Density | 1.4835 (rough estimate) |
refractive index | 1.6070 (estimate) |
Flash point | 11 °C |
storage temp. | −20°C |
solubility | Practically insoluble in water, sparingly soluble in ethanol (96 per cent), sparingly soluble or slightly soluble in methylene chloride. |
pka | pK1 1.3; pK2 11.5(at 25℃) |
Water Solubility | 54mg/L(temperature not stated) |
BCS Class | 1 |
Stability | hygroscopic |
CAS DataBase Reference | 846-49-1(CAS DataBase Reference) |
NIST Chemistry Reference | Lorazepam(846-49-1) |
EPA Substance Registry System | Lorazepam (846-49-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08 |
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Signal word | Warning | |||||||||
Hazard statements | H361 | |||||||||
Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
Hazard Codes | Xn,T,F | |||||||||
Risk Statements | 63-39/23/24/25-23/24/25-11-36-20/21/22 | |||||||||
Safety Statements | 36/37-45-16 | |||||||||
RIDADR | UN 1230 3/PG 2 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | DF0350000 | |||||||||
HS Code | 2933910000 | |||||||||
Toxicity | LD50 in mice, rats (mg/kg): 3178, >5000 orally (Owen) | |||||||||
NFPA 704 |
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Lorazepam Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Uses
An anxiolytic, and anticonvulsant. Controlled substance (depressant)
General Description
Lorazepam, 7-chloro-5-(2-chlorophenyl)-3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one(Ativan), is the 2'-chloro derivative of oxazepam. In keepingwith overall SARs, the 2'-chloro substituent increases activity.As with oxazepam, metabolism is relatively rapid anduncomplicated because of the 3-hydroxyl group in the compound.Thus, it also has short half-life (2–6 hours) and similarpharmacological activity.
Biological Activity
Ligand at the GABA A receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.
Lorazepam Preparation Products And Raw materials
Raw materials
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846-49-1(Lorazepam)Related Search:
4-Chlorophenyl isocyanate
Triphenylmethyl Chloride
Chlorodiphenylmethane
Chlorodimethylphenylsilane
CHLOROPHOSPHONAZO III
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8133 CB
7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one
Lorazepam CIV (200 mg)
Acetonitrile( Test Lorazepam, 1.0 mg/mL )
LorazepaM (CIV), USP
(+-)-lorazepammethanolsolution
1,4-benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one
7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
Almazine
delormetazepam
AURORA KA-7219
EMOTIVAL
(+/-)-LORAZEPAM
LORAZEPAM
WY 4036
(+-)-lorazepam--dea schedule iv item
Wy-403
LORAZEPAM,USP
Alzapam
9-chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one
demethyllormetazepam
norlormetazepam
o-Chlorooxazepam
o-Chloroxazepam
Punktyl
Quait
Securit
Sedatival
Sedazin
Somagerol
Tavor
Temesta
Wypax
7-CHLORO-5-[2-CHLOROPHENYL]-1,3-DIHYDRO-3-HYDROXY-2H-1,4-BENZODIAZEPIN-2-ONE
LORSILAN
LORAX
Lorazepam (CRM)
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1H-benzo[e][1,4]diazepin-2(3H)-one
Lorazepam USP/EP/BP
Lorazepam tablets (2.5 mg)
(±)-Lorazepam solution
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
Lorazepam CIV (200 mg)I1D4040.998mg/mg(ai)
ATIVAN
846-49-1
C15H10C12N2O2
C1313C2H10Cl2N15NO2
API's
Intermediates & Fine Chemicals
Pharmaceuticals
Isotope Labeled Compounds