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2-Chlorotrityl chloride

CAS No.: 42074-68-0

Chemical Name:: 2-Chlorotrityl chloride

Synonyms: 2-CHLOROTRITYL CHLORIDE RESIN;CTC resin;2-CHLOROTRITYL RESIN;2-CHLOROTRITYLCHLORIDE POLYMER RESIN;2CTC Resin;2-CHLOROPHENYLDIPHENYLMETHYL CHLORIDE;CL-TRT(2-CL)-RESIN;1-chloro-2-(chlorodiphenylmethyl)benzene;(chloro(2-chlorophenyl)Methylene)dibenzene;BR-1060

CBNumber:: CB9853612

Molecular Formula:: C19H14Cl2

Molecular Weight:: 313.22

MOL File:: 42074-68-0.mol

MSDS File:: SDS

Modify Date:: 2024/7/30 14:17:11

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2-Chlorotrityl chloride Properties

Melting point	130-135 °C
Boiling point	421.3±40.0 °C(Predicted)
Density	1.222±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in Chloroform, methanol and dichloromethane, insoluble in water
form	Powder
color	Pale yellow crystalline powder
BRN	1983914
CAS DataBase Reference	42074-68-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Warning

Hazard statements

H290-H315-H319-H335

Precautionary statements

P234-P261-P264-P271-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-24/25-22

RIDADR

3261

WGK Germany

10-21

HS Code

2903 99 80

HazardClass

PackingGroup

III

NFPA 704

	1
0		0

2-Chlorotrityl chloride price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	8.51061	2-Chlorotrityl chloride Novabiochem?	42074-68-0	25G	₹11390.01	2022-06-14	Buy
Sigma-Aldrich(India)	26569	2-Chlorotrityl chloride ≥97.0% (AT)	42074-68-0	10G	₹14210.85	2022-06-14	Buy
ALFA India	ALF-044407-18	2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 100-200 mesh, 1.0-1.4 mmol/g	42074-68-0	50g	₹60740	2022-05-26	Buy
ALFA India	ALF-044407-09	2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 100-200 mesh, 1.0-1.4 mmol/g	42074-68-0	10g	₹14747	2022-05-26	Buy
TCI Chemicals (India)	D2504	2-Chlorotrityl Chloride	42074-68-0	25G	₹6500	2022-05-26	Buy

Product number	Packaging	Price	Buy
8.51061	25G	₹11390.01	Buy
26569	10G	₹14210.85	Buy
ALF-044407-18	50g	₹60740	Buy
ALF-044407-09	10g	₹14747	Buy
D2504	25G	₹6500	Buy

2-Chlorotrityl chloride Chemical Properties,Uses,Production

Chemical Properties

off-white to yellow or brown beads

Uses

2-Chlorotrityl chloride is used as an intermediate of clotrimazole. It is also used in the preparation of modified trityl nucleosides as inhibitors of P. falciparum dUTPase. In addition, it serves as a protecting group reagent for carboxylic acids forming esters.

Application

2-Chlorotrityl Chloride is used in convergent peptide synthesis. Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA.

Preparation

2-Chlorotrityl chloride synthesis: It is esterified with 2-Chlorobenzoic acid and ethanol in the presence of sulfuric acid or p-toluenesulfonic acid to generate Ethyl 2-Chlorobenzoate, which is then condensed with phenylmagnesium bromide (Grignard reaction) to obtain (2-Chlorophenyl)diphenylmethanol magnesium salt is hydrolyzed with sulfuric acid to obtain (2-Chlorophenyl)diphenylmethanol, which is then chlorinated with thionyl chloride to obtain the product.

Biotechnological Applications

The 2-chlorotrityl chloride (2-CTC) resin is one of the most frequently used and most versatile resins for the large-scale manufacture of peptides. It is slightly less acid-labile than Trityl Resin and thus more widely used in solid phase peptide synthesis. Peptides UBI-8 and UBI-9 were synthesized by Fmoc-solid phase chemistry using a 2-chlorotrityl chloride linker-resin. Trityl linkers have certain advantages in comparison to the alkoxybenzyl alcohol (eg. Wang resin), especially in the area of peptide chemistry. First, the problem of racemization during the loading of the first amino acid (using DIPEA) is avoided with trityl linkers. Second, due to steric factors, no diketopiperazine formation is observed.

2-Chlorotrityl chloride Preparation Products And Raw materials

Raw materials

Ethyl 2-Chlorobenzoate Bromobenzene 2-Chlorobenzoic acid PARA TOLUENE MAGNESIUM METHOXIDE

Benzhydrol Thionyl chloride CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Methyl 2-chlorobenzoate 2-Chlorobenzotrichloride

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Preparation Products

Clotrimazole

2-Chlorotrityl chloride Suppliers

Global( 341)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Danopharm Chemicals Pvt.Ltd.	+91 9821080785	Mumbai, India	37	58	Inquiry
NB Healthcare Pvt Ltd	+91 7227055467	Gujarat, India	37	58	Inquiry
SHIVAM PETROCHEM INDUSTRIES	+91-9824336772 +91-9824336772	Gujarat, India	5	58	Inquiry
Covalent Incorporation	+91-9033666099 +91-9033666099	Gujarat, India	50	58	Inquiry
Horizon Chemicals	+undefined-9426020080 +undefined-9717770497	Gujarat, India	12	58	Inquiry
Sibram Pharmaceutical	+91-8655777550 +91-8655777550	Maharashtra, India	244	58	Inquiry
Navone Specialties (OPC) Pvt Ltd	+91-9323789882 +91-9323789882	Maharashtra, India	144	58	Inquiry
Bharavi Laboratories (P) Ltd.	91 80 2666 7742	New Delhi, India	359	54	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry

Supplier	Advantage
Danopharm Chemicals Pvt.Ltd.	58
NB Healthcare Pvt Ltd	58
SHIVAM PETROCHEM INDUSTRIES	58
Covalent Incorporation	58
Horizon Chemicals	58
Sibram Pharmaceutical	58
Navone Specialties (OPC) Pvt Ltd	58
Bharavi Laboratories (P) Ltd.	54
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58

42074-68-0(2-Chlorotrityl chloride)Related Search:

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Ferric acetylacetonate METHYL ISOCYANOACETATE N-BUTYLISOCYANIDE TERT-BUTYL ISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)

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Diphenyl-2-chlorophenylMethyl Chloride o-ChlorotriphenylchloroMethane Chloro(2-chlorophenyl)diphenylmethane (2-Chlorophenyl)diphenylmethyl Chloride ClotriMazole IMpurity C 2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 1.0 to 1.4 mmol/g KNORR-TRT(2-CL)-RESIN KNORR-2-CHLOROTRITYL RESIN KNORR 2-CT RESIN CHLORO-2-CHLOROPHENYLDIPHENYLMETHANE CHLORO(2-CHLOROPHENYL)PHENYLMETHYL POLYSTYRENE RESIN CL-TRT(2-CL) DIPHENYL-O-CHLOROPHENYLCHLOROMETHANE H-KNORR-2-CHLOROTRITYL RESIN BARLOS (2-CHLOROTRITYL CHLORIDE) RESIN BARLOS RESIN AMINO-2,4-DIMETHOXY-4'-(CARBOXYMETHYLOXY)BENZHYDRYLAMINE HANDLE LINKED TO 2-CHLOROTRITYL RESIN RINK AMIDE 2-CHLOROTRITYL RESIN RINK-BERNATOWITZ-AMIDE BARLOS RESIN RINK AMIDE BARLOS RESIN PL CL-TRT-CL RESIN NH2-SAL-TRT(2-CL)-RESIN O-CHLOROTRITYL CHLORIDE O-CHLORPHENYL-DIPHENYL-CHLOROMETHANE TRT(2-CL)-CL Chloro-(o-chlorophenyl)diphenylmethane Diphenyl(2-Chlorophenyl)Chloromethane O-CHLORPHENYL-DIPHENYL-CHLOROMETHANE(CLOTRIMAZOLE INTERMEDIATE ) 100-200mesh,1%DVB,1.0-1.6mmol/g] 2-Chlorotritylchlorideresine BARLOS-resine BR-1060 2-CHLOROPHENYL DIPHENYL CHLOROMETHANE Benzene,1-chloro-2-(chlorodiphenylMethyl)- 2-Chlorotrityl Chloride, 95.0%(T) 2-Chlorotrityl chloride, polymer-bound 200-400 mesh, extent of labeling: 1.0-1.5 mmol/g Cl loading, 1 % cross-linked 2-Chlorotriphenylmethyl chloride resin 2-Chlorotrityl chloride resin(1.0-1.2 meq/g, 200-400 mesh) 2-Chlorotrityl chloride resin(1.0-2.0 meq/g, 100-200 mesh) 2-Chlorotrityl chloride resin(1.0-1.8 meq/g, 100-200 mesh) 2-Chlorotrityl chloride resin(0.3-0.8 meq/g, 200-400 mesh) 2,4-DIMETHOXY-4'-(CARBOXYMETHYLOXY)-BENZHYDRYLAMINE HANDLE LINKED TO 2-CHLOROTRITYL RESIN 2,A-DICHLORO TRIPHENYL METHANE 2,ALPHA-DICHLOROBENZHYDRYL-POLYSTYRENE CROSSLINKED WITH DIVINYLBENZENE 2,ALPHA-DICHLOROBENZHYDRYLPOLYSTYRENE DIVINYLBENZENE COPOLYMER 2-CL-(TRT)-CL RESIN 2-CLTRT RESIN 2CT-CL RESIN 2CT-CL RESIN 100 2CT-CL RESIN 200 2-CHLOROTRIPHENYL CHLOROMETHANE 2-CHLOROTRIPHENYL CHLOROMETHANE RESIN 2-CHLOROTRITYL KNORR RESIN 2-CHLOROTRITYL CHLORIDE 2-CHLOROTRITYL CHLORIDE ON POLYSTYRENE RESIN 2-CHLOROTRITYL CHLORIDE, POLYMER-BOUND 2-CHLOROTRITYLCHLORIDE PS RESIN 2-CHLOROTRITYL CHLORIDE RESIN (50-100 MESH, 1% DVB, 1.0-1.6 MMOL/G) 2-CHLOROTRITYL CHLORIDE RESIN (100-200 MESH, 1% DVB, 1.0-1.6 MMOL/G)