Clotrimazole
- CAS No.
- 23593-75-1
- Chemical Name:
- Clotrimazole
- Synonyms
- CLOTRIMAZOL;(2-Chlorophenyl)diphenyl-1-imidazolylmethane;CLT;clotrimazole powder;myclo;hemagglutinin;mycelex-g;Chlotrimazole;gyne-lotrimin;ClotriMazole(Canesten)
- CBNumber:
- CB7404063
- Molecular Formula:
- C22H17ClN2
- Molecular Weight:
- 344.84
- MOL File:
- 23593-75-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 147-149°C |
|---|---|
| Boiling point | 501.14°C (rough estimate) |
| Density | 1.1095 (rough estimate) |
| refractive index | 1.5940 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in chloroform, DMSO, DMF and alcohols |
| pka | pKa 4.7(EtOH 50%aq ) (Uncertain) |
| form | Solid |
| color | White to Almost white |
| Water Solubility | <10mg/L(25 ºC) |
| λmax | 556nm(Phosphate buffer sol.)(lit.) |
| Merck | 14,2417 |
| InChI | InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H |
| InChIKey | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
| SMILES | C1N(C(C2=CC=CC=C2Cl)(C2=CC=CC=C2)C2=CC=CC=C2)C=CN=1 |
| NIST Chemistry Reference | Clotrimazole(23593-75-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NI4377000 | |||||||||
| HS Code | 29332900 | |||||||||
| Toxicity | LD50 in male mice, rats (mg/kg): 923, 708 orally (Tettenborn) | |||||||||
| NFPA 704 |
|
Clotrimazole price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C6019 | Clotrimazole | 23593-75-1 | 5G | ₹10143.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1058 | Clotrimazole Pharmaceutical Secondary Standard; Certified Reference Material | 23593-75-1 | 1G | ₹8356.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C6019 | Clotrimazole | 23593-75-1 | 25G | ₹32388.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C6019 | Clotrimazole | 23593-75-1 | 100G | ₹88277.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 33894 | Clotrimazole VETRANAL?, analytical standard | 23593-75-1 | 100MG | ₹9309.5 | 2022-06-14 | Buy |
Clotrimazole Chemical Properties,Uses,Production
Description
Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections. It tightly binds sterol 14-
Chemical Properties
White or pale yellow, crystalline powder.
Uses
Clotrimazole is an antifungal agent.
Indications
Clotrimazole (Lotrimin, Gyne-Lotrimin, Mycelex) is a
broad-spectrum fungistatic imidazole drug used in the
topical treatment of oral, skin, and vaginal infections
with C. albicans. It is also employed in the treatment of
infections with cutaneous dermatophytes.
Topical use results in therapeutic drug concentrations
in the epidermis and mucous membranes; less
than 10% of the drug is systemically absorbed. Although
clotrimazole is generally well tolerated, local abdominal
cramping, increased urination, and transient
liver enzyme elevations have been reported.
Definition
ChEBI: A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.
General Description
Chemical structure: imidazole
Clinical Use
1-(o-Chloro-α,α-diphenylbenzyl)imidazole (Lotrimin, Gyne-Lotrimin, Mycelex) is a broad-spectrum antifungal drug thatis used topically for the treatment of tinea infections and candidiasis.It occurs as a white crystalline solid that is sparinglysoluble in water but soluble in alcohol and most organic solvents.It is a weak base that can be solubilized by dilute mineralacids.
Clotrimazole is available as a solution in polyethyleneglycol 400, a lotion, and a cream in a concentration of 1%.These are all indicated for the treatment of tinea pedis, tineacruris, tinea capitis, tinea versicolor, or cutaneous candidiasis.A 1% vaginal cream and tablets of 100 mg and 500 mgare available for vulvovaginal candidiasis. Clotrimazole isextremely stable, with a shelf life of more than 5 years.
Clotrimazole Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| HEMA PHARMACEUTICALS PVT LTD | +91-9537936912 +91-9537936912 | Gujarat, India | 48 | 58 | Inquiry |
| Halcyon Labs Pvt. Ltd | +919833750169 | Mumbai, India | 17 | 58 | Inquiry |
| NB Healthcare Pvt Ltd | +91 7227055467 | Gujarat, India | 37 | 58 | Inquiry |
| THE MOLECULEZ | +91-7506703683 +91-7506703683 | Maharashtra, India | 79 | 58 | Inquiry |
| Unilab Company | +91-912228260263 +91-63917864522 | Tamil Nadu, India | 43 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Shiv pharma chem | +91-9974421207 +91-9974421207 | Gujarat, India | 52 | 58 | Inquiry |
| AnalyticsStanza Inc | +91-7032031309 +91-7032031309 | Hyderabad, India | 227 | 58 | Inquiry |
| Vadivarhe Speciality Chemicals Limited | +91-9028832204 +91-9028832204 | Maharashtra, India | 38 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| HEMA PHARMACEUTICALS PVT LTD | 58 |
| Halcyon Labs Pvt. Ltd | 58 |
| NB Healthcare Pvt Ltd | 58 |
| THE MOLECULEZ | 58 |
| Unilab Company | 58 |
| SNECOFRi Pvt Ltd | 58 |
| Shiv pharma chem | 58 |
| AnalyticsStanza Inc | 58 |
| Vadivarhe Speciality Chemicals Limited | 58 |
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