Gramine
- CAS No.
- 87-52-5
- Chemical Name:
- Gramine
- Synonyms
- Gramin;DONAXINE;1-(1H-indol-3-yl)-N,N-dimethylmethanamine;Donaxin;GRAMINE;Doranine;NSC 16892;GRAMINE(RG);Gramine >Gramine,>99%
- CBNumber:
- CB7342118
- Molecular Formula:
- C11H14N2
- Molecular Weight:
- 174.24
- MOL File:
- 87-52-5.mol
- Modify Date:
- 2023/10/21 16:02:36
| Melting point | 132-134 °C (lit.) |
|---|---|
| Boiling point | 295.23°C (rough estimate) |
| Density | 1.0715 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Flash point | 167 °C |
| storage temp. | Refrigerator (+4°C) |
| solubility | almost transparency in Methanol |
| form | Powder |
| pka | 17.00±0.30(Predicted) |
| color | Beige |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Merck | 14,4533 |
| BRN | 140521 |
| LogP | 2.177 (est) |
| CAS DataBase Reference | 87-52-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-Indole-3-methanamine, N,N-dimethyl-(87-52-5) |
| EPA Substance Registry System | 1H-Indole-3-methanamine, N,N-dimethyl- (87-52-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352+P312-P362+P364 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 45-36/37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NL7525000 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Gramine price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G10806 | Gramine 99% | 87-52-5 | 25G | ₹4817.13 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D0653 | Gramine | 87-52-5 | 25G | ₹3200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D0653 | Gramine | 87-52-5 | 250G | ₹8800 | 2022-05-26 | Buy |
Gramine Chemical Properties,Uses,Production
Chemical Properties
?3-(Dimethylaminomethyl)indole [87-52-5], gramine, C11H14N2, Mr 174.25, mp 138 – 139 ℃, forms colorless needles. The compound is soluble in ethanol, diethyl ether, and chloroform and insoluble in water. It can be synthesized from indole by the Mannich reaction with dimethyl-amine and formaldehyde. Gramine is used to synthesize D,L-tryptophan, the plant growth regulators indole-3-acetic acid and indole-3-butanoic acid as well as the intermediate tryptamine.
Uses
Reactant for preparation of:
- Dopamine D2 receptor antagonists
- Anti-malarial drugs
- 5-indolyl-Mannich bases
- Proliferation inhibitors
- Inhibitors of human mast cell chymase
- Preparation of DL-tryptophan
- Potential detoxification inhibitors of the crucifer phytoalexin brassinin
- 3-vinylindoles
- Serotonin 5-HT6 receptor ligand templates
- Selective protein kinase c delta (PKCδ) down regulators
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Purification Methods
Crystallise gramine from diethyl ether, ethanol or acetone. It sublimes at 59o/0.001mm. The hydrochloride crystallises from EtOH/Et2O with m 190.5-191.0o(dec). [Culvenor et al. Aust J Chem 17 1301 1964, Beilstein 22 III/IV 4302, 22/10 V 25.]
Gramine Preparation Products And Raw materials
Raw materials
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Global( 377)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SL Drugs and Pharmaceuticals Pvt. Ltd. | +91 (40) 6661-1133 | New Delhi, India | 2688 | 50 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Define Chemicals | 91-251-2600443 | Maharashtra, India | 37 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Vyas Bio Life Sciences Pvt. Ltd | -65546373 | Hyderabad, India | 1213 | 58 | Inquiry |
| Vadivarhe Speciality Chemicals Limited | 08048372056Ext 452 | Maharashtra, India | 22 | 58 | Inquiry |
| Oceanic Pharmachem Pvt. Ltd. | 91-22-42128600 | Maharashtra, India | 2006 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20294 | 58 | Inquiry |
87-52-5(Gramine)Related Search:
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b-(Dimethylaminomethyl)indole
Donaxin
(1H-INDOL-3-YLMETHYL)-DIMETHYL-AMINE
(GRAMINE)
3-(Dimethylaminomethyl)-indole for synthesis
3-((N,N-DIMETHYLAMINO)METHYL)INDOLE (GRAMINE)
n,n-dimethyl-1h-indole-3-methanamine
indol-3-ylmethyldimethylamine
GCLH / for Cefixime
3-(dimethylaninomethy)in dole
Indole, 3-[(dimethylamino)methyl]-
n,n-dimethyl-1h-indole-3-methanamin
N,N-Dimethyl-1H-indole-3-methylamine
TIMTEC-BB SBB003799
1H-Indole-3-methanamine, N,N-dimethyl-
(1H-INDOL-3-YLMETHYL)-DIMETHYL-AMINE
3-(DIMETHYLAMINOMETHYL)INDOLE
GRAMINE
BETA-DIMETHYLAMINOMETHYLINDOLE
3-(DIMETHYLAMINOMETHYL)-INDOLE FOR SYNTH
Doranine
3-((N,N-DIMETHYLAMINO)METHYL)INDOLE
NSC 16892
Gramine,>99%
3-(Dimethylaminomethyl)Indole,Gramines
3-(Dimethy Amino Methyl) Indole
3-(diemthylaminomethyl)indole
GRAMINE(3-(DIMETHYLAMINOMETHYL)INDOLE)
Gramine or 3-(Dimethylaminomethyl)indole
Indole-2-carbocylic acid
DONAXINE:GRAMINE
Tri(ethenyl)methylsilane
3-Dimethylaminomethyl-1H-indole
N,N-Dimethyl-1H-indole-3-ylmethaneamine
GRAMINE(RG)
3-(Dimethylaminomethyl)indole
Donaxine
Arundo donax base
3-(DiMethylaMinoMethyl)indole (graMine)
1H-Indol-3-yl-N,N-dimethylmethanamine
3-((dimethylamino)methyl)-indol
3-Dimethylaminomethylindol (gramin)
Gramine >
Gramin
DONAXINE
1-(1H-indol-3-yl)-N,N-dimethylmethanamine
Gramine, ≥ 98.0%
87-52-5
C11H14N2
Indole Alkaloids
Simple Indoles
Indoles
Alkaloids
Building Blocks
Heterocyclic Building Blocks
Indole
Indoles
Pharmaceutical Intermediates
indole derivative
Indoles and derivatives