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N-Methyl-N-(trimethylsilyl)trifluoroacetamide

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Structure
CAS No.
24589-78-4
Chemical Name:
N-Methyl-N-(trimethylsilyl)trifluoroacetamide
Synonyms
MSTFA;DK232;MSTFA MSTFA;MSTFA Reagent;MSTFA ACTIVATED I;MSTFA+TMCS (99:1);MSTFA ACTIVATED II;MSTFA ACTIVATED III;MSTFA with 1 % TMCS;N-Methyl-N-(trimethy
CBNumber:
CB0161574
Molecular Formula:
C6H12F3NOSi
Molecular Weight:
199.25
MOL File:
24589-78-4.mol
Modify Date:
2024/8/17 21:30:02

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Properties

Melting point 98-100°C
Boiling point 130132°C
Density 1.075 g/mL at 25 °C(lit.)
vapor density >1 (vs air)
vapor pressure 8.8 mm Hg ( 27 °C)
refractive index n20/D 1.383
Flash point 77 °F
storage temp. 2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
pka -1.34±0.70(Predicted)
form Liquid
color Clear colorless to light yellow
Specific Gravity 1.076
Water Solubility reacts
Sensitive Moisture Sensitive
Hydrolytic Sensitivity 7: reacts slowly with moisture/water
BRN 1941550
InChIKey MSPCIZMDDUQPGJ-UHFFFAOYSA-N
CAS DataBase Reference 24589-78-4(CAS DataBase Reference)
EPA Substance Registry System Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)- (24589-78-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319-H335
Precautionary statements  P210-P302+P352-P305+P351+P338
Hazard Codes  Xi,F,T,N
Risk Statements  10-36/37/38-61-50/53-51/53
Safety Statements  26-36-37/39-16-45-53-61
RIDADR  UN 1993 3/PG 3
WGK Germany  3
RTECS  AC9800000
10-21
Hazard Note  Flammable
TSCA  T
HazardClass  3
PackingGroup  III
HS Code  29319090
NFPA 704
2
2 1

N-Methyl-N-(trimethylsilyl)trifluoroacetamide price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) M7891 N-Methyl-N-(trimethylsilyl)trifluoroacetamide BioReagent, for silylations, LiChropur? 24589-78-4 1ML ₹4524.85 2022-06-14 Buy
Sigma-Aldrich(India) M7891 N-Methyl-N-(trimethylsilyl)trifluoroacetamide BioReagent, for silylations, LiChropur? 24589-78-4 5G ₹5152.7 2022-06-14 Buy
Sigma-Aldrich(India) M7891 N-Methyl-N-(trimethylsilyl)trifluoroacetamide BioReagent, for silylations, LiChropur? 24589-78-4 25G ₹17287.53 2022-06-14 Buy
Sigma-Aldrich(India) M7891 N-Methyl-N-(trimethylsilyl)trifluoroacetamide BioReagent, for silylations, LiChropur? 24589-78-4 10X1ML ₹18748.9 2022-06-14 Buy
Sigma-Aldrich(India) 8.41102 N-Methyl-N-trimethylsilyl-trifluoroacetamide for synthesis 24589-78-4 5ML ₹1790 2022-06-14 Buy
Product number Packaging Price Buy
M7891 1ML ₹4524.85 Buy
M7891 5G ₹5152.7 Buy
M7891 25G ₹17287.53 Buy
M7891 10X1ML ₹18748.9 Buy
8.41102 5ML ₹1790 Buy

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Chemical Properties,Uses,Production

Chemical Properties

Clear colorless to light yellow liquid

Uses

N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone.

Definition

ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivat sation agent used in gas chromatography/mass spectrometry applications.

General Description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.

Purification Methods

Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Preparation Products And Raw materials

Global( 285)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
Oceanic Pharmachem Pvt., Ltd. (OPPL) 91-22-42128600 Maharashtra, India 947 58 Inquiry
VASIN BIO LIFE SCIENCES PVT LTD 9491644688 Hyderabad, India 2096 58 Inquiry
Spectrochem Private Limited 08048372608Ext 246 Maharashtra, India 1056 58 Inquiry
Survival Technologies Pvt Ltd +91 (22) 4212-8221 New Delhi, India 290 50 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Sisco Research Laboratories Pvt. Ltd. +91-22-4268 5800 Mumbai, India 4317 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Triveni chemicals 08048762458 New Delhi, India 6093 58 Inquiry
N-METHYL-N-(TRIMETHYLSILYL)TRIFLUOROACETAMIDE W. 1% TMCS N-METHYL-N-(TRIMETHYLSILYL)TRIFLUORO-ACE TAMIDE, DERIVATIZATION GRADE N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACET-A MIDE, FOR GC N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAM, 10x1ML PACKSIZE N-METHYL-N-(TRIMETHYLSILYL)TRIFLUOROACETAMIDE 98% N-Methyl-N-(Trimethylsily)Trifluoroacetamide N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 98 MSTFA~N-Trimethylsilyl-N-methyltrifluoroacetamide N- Methyl-N-three Methylsilane threefluoroacetaMide N-Methyl-N-trimethylsilyltrifluoroacetamide(MSTFA) N-Methyl-N-trimethylsilyltrifluoroacetamide[trimethylsilylatingagent] Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)- n-methyl-n-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane MSTFA (Reagent Grade for Silylating) MSTFA, N-(Trifluoroacetyl)-N-(trimethylsilyl)methylamine, (N-Methyltrifluoroacetamido)trimethylsilane MSTFA (N-Methy-N-(triMethylsilyl)trifluoroacetaMide 2,2,2-TRIFLUORO-N-METHYL-N-(TRIMETHYLSILYL)-ACETAMIDE N-METHYL-N-(TRIMETHYLSILYL)TRIFLUORO N-METHYL-N-TMS-TRIFLUOROACETAMIDE N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE ACTIVATED I N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE ACTIVATED II N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE ACTIVATED III N-METHYL-N-(TRIMETHYLSILYL)-2,2,2-TRIFLUOROACETAMIDE N-METHYLTRIMETHYLSILYLTRIFLUORACETAMIDE N-METHYLTRIMETHYLSILYLTRIFLUOROACETAMIDE N-TRIMETHYLSILYL-N-METHYL TRIFLUOROACETAMIDE MSTFA ACTIVATED I MSTFA ACTIVATED II MSTFA ACTIVATED III MSTFA activated III, N-Methyl-N-trimethylsilyltrifluoroacetamide imidazole mixture N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA 2,2,2-trifluoro-n-methyl-n-(trimethylsilyl)-acetamid MSTFA MSTFA 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide for gas chromatography N-(Trimethylsilyl)-N-methyl-2,2,2-trifluoroacetamide N-Methyl-N-trimethylsilyltrifluoracetamide N-Methyl-N-(trimethylsilyl)trifluoroacetamide,97% N-Methyl-N-(trimethylsilyl)trifluoroacetamide,N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA N-Methyl-N-(trimethylsilyl)trifluoroacetamide 99+% N-Methyl-N-(trimethy MSTFA Reagent N-Methyl-N-triMethylsilyltrifluoroacetaMide  N-Methyl-N-(triMethylsilyl)trifluoroacetaMide, 97% 5GR 2,2,2-TRIFLUORO-N-METHYL-N-(TRIMETHYLSIL MSTFA with 1 % TMCS N-methy-N-(trimethylsilyl) trifluoroacetamide MSTFA, 5x10 ml, 25 g N-Methyl-N-trimethylsilyltrifluoroacetamide[TrimethylsilylatingAgent]> CAS24589-78-4 N-methyl-N-(trimethylsilyl)trifluoroacetamide N-Methyl-N-Trimethylsilyl Trifluoroacetamide (MSTFA) extrapure, 98% MSTFA+TMCS (99:1) MSTFA N-methyl-N- (trimethylmethyl silane) trifluoroacetamide DK232 N-Methyl-N- (trimethylsilyl)trifluoroacet N-Methyl-N-(trimethylsilyl)trifluoroacetamide,for GC derivatization N-Methyl-N-trimethylsilyltrifluoroacetamide, Trimethylsilylating Agent,≥ 90.0%