N-Methyl-N-(trimethylsilyl)trifluoroacetamide
![N-Methyl-N-(trimethylsilyl)trifluoroacetamide Structure](CAS/GIF/24589-78-4.gif)
- CAS No.
- 24589-78-4
- Chemical Name:
- N-Methyl-N-(trimethylsilyl)trifluoroacetamide
- Synonyms
- MSTFA;DK232;MSTFA MSTFA;MSTFA Reagent;MSTFA ACTIVATED I;MSTFA+TMCS (99:1);MSTFA ACTIVATED II;MSTFA ACTIVATED III;MSTFA with 1 % TMCS;N-Methyl-N-(trimethy
- CBNumber:
- CB0161574
- Molecular Formula:
- C6H12F3NOSi
- Molecular Weight:
- 199.25
- MOL File:
- 24589-78-4.mol
- Modify Date:
- 2024/8/17 21:30:02
Melting point | 98-100°C |
---|---|
Boiling point | 130132°C |
Density | 1.075 g/mL at 25 °C(lit.) |
vapor density | >1 (vs air) |
vapor pressure | 8.8 mm Hg ( 27 °C) |
refractive index |
n |
Flash point | 77 °F |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
pka | -1.34±0.70(Predicted) |
form | Liquid |
color | Clear colorless to light yellow |
Specific Gravity | 1.076 |
Water Solubility | reacts |
Sensitive | Moisture Sensitive |
Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
BRN | 1941550 |
InChIKey | MSPCIZMDDUQPGJ-UHFFFAOYSA-N |
CAS DataBase Reference | 24589-78-4(CAS DataBase Reference) |
EPA Substance Registry System | Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)- (24589-78-4) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS02,GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H226-H315-H319-H335 | |||||||||
Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi,F,T,N | |||||||||
Risk Statements | 10-36/37/38-61-50/53-51/53 | |||||||||
Safety Statements | 26-36-37/39-16-45-53-61 | |||||||||
RIDADR | UN 1993 3/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | AC9800000 | |||||||||
F | 10-21 | |||||||||
Hazard Note | Flammable | |||||||||
TSCA | T | |||||||||
HazardClass | 3 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29319090 | |||||||||
NFPA 704 |
|
N-Methyl-N-(trimethylsilyl)trifluoroacetamide price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | M7891 | N-Methyl-N-(trimethylsilyl)trifluoroacetamide BioReagent, for silylations, LiChropur? | 24589-78-4 | 1ML | ₹4524.85 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | M7891 | N-Methyl-N-(trimethylsilyl)trifluoroacetamide BioReagent, for silylations, LiChropur? | 24589-78-4 | 5G | ₹5152.7 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | M7891 | N-Methyl-N-(trimethylsilyl)trifluoroacetamide BioReagent, for silylations, LiChropur? | 24589-78-4 | 25G | ₹17287.53 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | M7891 | N-Methyl-N-(trimethylsilyl)trifluoroacetamide BioReagent, for silylations, LiChropur? | 24589-78-4 | 10X1ML | ₹18748.9 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 8.41102 | N-Methyl-N-trimethylsilyl-trifluoroacetamide for synthesis | 24589-78-4 | 5ML | ₹1790 | 2022-06-14 | Buy |
N-Methyl-N-(trimethylsilyl)trifluoroacetamide Chemical Properties,Uses,Production
Chemical Properties
Clear colorless to light yellow liquid
Uses
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone.
Definition
ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivat sation agent used in gas chromatography/mass spectrometry applications.
General Description
N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.
Purification Methods
Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]
N-Methyl-N-(trimethylsilyl)trifluoroacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
Oceanic Pharmachem Pvt., Ltd. (OPPL) | 91-22-42128600 | Maharashtra, India | 947 | 58 | Inquiry |
VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2096 | 58 | Inquiry |
Spectrochem Private Limited | 08048372608Ext 246 | Maharashtra, India | 1056 | 58 | Inquiry |
Survival Technologies Pvt Ltd | +91 (22) 4212-8221 | New Delhi, India | 290 | 50 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
N-Methyl-N-(trimethylsilyl)trifluoroacetamide Spectrum
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