ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Amide >N,O-Bis(trimethylsilyl)acetamide
N,O-Bis(trimethylsilyl)acetamide
- CAS No.
- 10416-59-8
- Chemical Name:
- N,O-Bis(trimethylsilyl)acetamide
- Synonyms
- BSA;BIS(TRIMETHYLSILYL)ACETAMIDE;TriMethylsilyl N-(triMethylsilyl)acetiMidate;TMS-BA;dynasylan bsa;bis(trimethylsllyl)acetamide;N.O-Bis(trimethylsilyl)acetamide (BSA);(E)-TriMethylsilyl N-(triMethylsilyl)acetiMidate;trimethylsilyl (1E)-N-trimethylsilylethanimidate;BSiA
- CBNumber:
- CB7366985
- Molecular Formula:
- C8H21NOSi2
- Molecular Weight:
- 203.43
- MOL File:
- 10416-59-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/1 19:01:27
| Melting point | 24 °C |
|---|---|
| Boiling point | 71-73 °C35 mm Hg(lit.) |
| Density | 0.832 g/mL at 20 °C(lit.) |
| vapor pressure | 10 hPa (50 °C) |
| refractive index |
n |
| Flash point | 53 °F |
| storage temp. | Store below +30°C. |
| solubility | Miscible with many nonpolar and polar aprotic solvents. |
| form | Crystalline Powder, Crystals and/or Chunks |
| pka | 5.82±0.50(Predicted) |
| Specific Gravity | 0.832 |
| color | Light yellow or beige to brown |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 1306669 |
| CAS DataBase Reference | 10416-59-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8) |
| EPA Substance Registry System | Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester (10416-59-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H302-H314 | |||||||||
| Precautionary statements | P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | C,Xn,F | |||||||||
| Risk Statements | 10-14-22-34-40-20/21/22-11 | |||||||||
| Safety Statements | 26-36/37/39-45-7/8-43A-36-30-23-16-7/9 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AK3000000 | |||||||||
| F | 10-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29310095 | |||||||||
| Toxicity | LD50 orally in Rabbit: 1580 mg/kg | |||||||||
| NFPA 704 |
|
N,O-Bis(trimethylsilyl)acetamide price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.18727 | N,O-Bis(trimethylsilyl)acetamide for synthesis | 10416-59-8 | 25ML | ₹8720.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.18727 | N,O-Bis(trimethylsilyl)acetamide for synthesis | 10416-59-8 | 100ML | ₹16720 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 15269 | N,O-Bis(trimethylsilyl)acetamide for GC derivatization, LiChropur?, ≥98.5% (GC) | 10416-59-8 | 5ML | ₹4297.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 15269 | N,O-Bis(trimethylsilyl)acetamide for GC derivatization, LiChropur?, ≥98.5% (GC) | 10416-59-8 | 10X1ML | ₹15209.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 15269 | N,O-Bis(trimethylsilyl)acetamide for GC derivatization, LiChropur?, ≥98.5% (GC) | 10416-59-8 | 25ML | ₹16583.9 | 2022-06-14 | Buy |
N,O-Bis(trimethylsilyl)acetamide Chemical Properties,Uses,Production
Physical properties
bp 71–73°C/35 mmHg.
Uses
N,O-Bis(trimethylsilyl)acetamide is a powerful silylating agent; reacts with a wide range of functional
groups.
BSA was used to
trimethylsilylate the hydroxyl group of 12 selectively to form
in almost quantitative yield (eq 32).The presence of catalytic
amounts (～0.02 equiv) of tetrabutylammonium fluoride (TBAF)
significantly promoted the silylation of alcohols under mild conditions
with high chemoselectivity, i.e., TBAF plays a role as a
smooth silyl transfer catalyst from nitrogen to the hydroxyl group.
Preparation
made by the reaction of acetamide with a large excess of chlorotrimethylsilane in the presence of triethylamine.
General Description
N,O-Bis(trimethylsilyl)acetamide is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions.
Purification Methods
Fractionate it through a spinning band column and collect liquid b 71-73o/35mm, and not higher because the main impurity MeCONHSiMe3 distils at b 105-107o/35mm. It is used for derivatising alcohols and sugars [Klebe et al. J Am Chem Soc 88 3390 1966, see Matsuo et al. Carbohydr Res 241 209 1993, Johnson Carbohydr Res 237 313 1992]. Itis FLAMMABLE and TOXIC.
N,O-Bis(trimethylsilyl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
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Global( 645)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JIVICHEM SYNTHESIS PVT LTD | +91-7028392790 +91-7028392790 | Maharashtra, India | 337 | 58 | Inquiry |
| PERFECT CHEMICAL | +91-9820465461 +91-9820465461 | Mumbai, India | 391 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Lanya Chem Industries Pvt Ltd | +91-7290016802 +91-9996207397 | Haryana, India | 34 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JIVICHEM SYNTHESIS PVT LTD | 58 |
| PERFECT CHEMICAL | 58 |
| JSK Chemicals | 58 |
| Lanya Chem Industries Pvt Ltd | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
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- Nov 25，2019
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N,O-BIS(TRIMETHYLSILYL)ACETAMIDE
N,O-Bistrimethyl Sylyl Acetamide
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N,O-BIS(TRIMETHYLSILYL)ACETAMIDE FOR GAS
Trimethylsilyl N-(trimethylsilyl)ethanimidate, N,O-Bis(trimethylsilyl)acetamide, BSA
|N|,|O|-Bis(triMethylsilyl)acetaMide (TMS-BA)
BSA (25% in Acetonitrile)
N,O-Bis(triMethylsilyl)acetaMide synthesis grade, >=95%
N,O-Bis(trimethylsilyl)acetamide≥ 95% (Assay)
N-Trimethylsilyl-1-trimethylsilyloxyethanimine
1-(Trimethylsiloxy)-N-(trimethylsilyl)ethanimine
N-(Trimethylsilyl)-1-(trimethylsiloxy)ethanimine
N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 ml * 8
Reaction vial, capacity 2 ml * 8 N,O-Bis(trimethylsilyl)acetamide,95% N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 ml * 8 / Reaction vial, capacity 2 ml * 8 [Trimethylsilylating Reagent, for NH2 compounds] Bis(trimethylsilyl)acetamide 5g [10416-59-8] N,O-Bis(trimethylsil TMS-BA (25% in Acetonitrile) 1 ML * 8 / Reaction vial, capacity 2 ML * 8 [TriMethylsilylating Reagent, for NH2 coMpounds] N,O-Bis(triMethylsilyl)acetaMide, 95% 100ML N,O-Bis(triMethylsilyl)acetaMide, 95% 25ML TMS-BA BSA N,O-Bis(triMethylsilyl)acetaMide Kit Co-Formula CFS-598 trimethylsilyl N-trimethylsilylethanimidate N-(Trimethylsilyl)ethanimidic acid trimethylsilyl ester N,O-Bis(trimethylsiyl)acetamide 99%min Ht--406 Bis(Trimethylsilyl)Acetamide (Bsa) N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 mL * 8 / Reaction vial, capacity 2 mL * 8>
Reaction vial, capacity 2 ml * 8 N,O-Bis(trimethylsilyl)acetamide,95% N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 ml * 8 / Reaction vial, capacity 2 ml * 8 [Trimethylsilylating Reagent, for NH2 compounds] Bis(trimethylsilyl)acetamide 5g [10416-59-8] N,O-Bis(trimethylsil TMS-BA (25% in Acetonitrile) 1 ML * 8 / Reaction vial, capacity 2 ML * 8 [TriMethylsilylating Reagent, for NH2 coMpounds] N,O-Bis(triMethylsilyl)acetaMide, 95% 100ML N,O-Bis(triMethylsilyl)acetaMide, 95% 25ML TMS-BA BSA N,O-Bis(triMethylsilyl)acetaMide Kit Co-Formula CFS-598 trimethylsilyl N-trimethylsilylethanimidate N-(Trimethylsilyl)ethanimidic acid trimethylsilyl ester N,O-Bis(trimethylsiyl)acetamide 99%min Ht--406 Bis(Trimethylsilyl)Acetamide (Bsa) N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 mL * 8 / Reaction vial, capacity 2 mL * 8>