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ChemicalBook > Product Catalogue >Chemical Reagents >Organic reagents >Amide >N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide Structure
  • ₹486 - ₹55337.4
  • Product name: N,O-Bis(trimethylsilyl)acetamide
  • CAS: 10416-59-8
  • MF: C8H21NOSi2
  • MW: 203.43
  • EINECS:233-892-7
  • MDL Number:MFCD00008270
  • Synonyms:dynasylan bsa;Co-Formula CFS-598;trimethylsilyl N-trimethylsilylethanimidate;BIS(TRIMETHYLSILYL)ACETAMIDE;Acetimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester;bis(trimethylsllyl)acetamide ;CB2500;Ethanimidicacid,N-(trimethylsilyl)-,trimethylsilylester
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • SRL
  • ottokemi

Package

  • 5ML
  • 10X1ML
  • 10ML
  • 12ML
  • 25gm
  • 25ML
  • 100gm
  • 100ML
  • 250ML
  • 500gm
  • 1L
  • 1KIT
  • ManufacturerTCI Chemicals (India)
  • Product numberB0510
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile) [Trimethylsilylating Reagent, for NH2 compounds]
  • Packaging12ML
  • Price₹1800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB0511
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide [Trimethylsilylating Agent] min. 80.0 %
  • Packaging10ML
  • Price₹2200
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA5602
  • Product descriptionTMS-BA [=N,O-Bis(trimethylsilyl)acetamide] (25% in Acetonitrile) [for Gas Chromatography]
  • Packaging5ML
  • Price₹2400
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA5601
  • Product descriptionBSA [=N,O-Bis(trimethylsilyl)acetamide] [for Gas Chromatography] min. 80.0 %
  • Packaging5ML
  • Price₹2500
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT0691
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 mL × 8 / Reaction vial, capacity 2 mL × 8 [Trimethylsilylating Reagent, for NH2 compounds]
  • Packaging1KIT
  • Price₹4100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB0911
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide Kit BSA 1 mL × 8 / Reaction vial, capacity 2 mL × 8 min. 80.0 %
  • Packaging1KIT
  • Price₹5100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB0511
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide [Trimethylsilylating Agent] min. 80.0 %
  • Packaging100ML
  • Price₹5900
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number128910
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95%
  • Packaging10ML
  • Price₹2219.13
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number128910
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95%
  • Packaging25ML
  • Price₹2316.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number15269
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for GC derivatization, LiChropur?, ≥98.5% (GC)
  • Packaging5ML
  • Price₹4297.53
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number128910
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95%
  • Packaging100ML
  • Price₹6527.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number8.18727
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for synthesis
  • Packaging25ML
  • Price₹8720.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number15269
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for GC derivatization, LiChropur?, ≥98.5% (GC)
  • Packaging10X1ML
  • Price₹15209.13
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number15269
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for GC derivatization, LiChropur?, ≥98.5% (GC)
  • Packaging25ML
  • Price₹16583.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number8.18727
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for synthesis
  • Packaging100ML
  • Price₹16720
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number1.09649
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for gas chromatography
  • Packaging25ML
  • Price₹25420
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B0510 N,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile) [Trimethylsilylating Reagent, for NH2 compounds] 12ML ₹1800 2022-05-26 Buy
TCI Chemicals (India) B0511 N,O-Bis(trimethylsilyl)acetamide [Trimethylsilylating Agent] min. 80.0 % 10ML ₹2200 2022-05-26 Buy
TCI Chemicals (India) A5602 TMS-BA [=N,O-Bis(trimethylsilyl)acetamide] (25% in Acetonitrile) [for Gas Chromatography] 5ML ₹2400 2022-05-26 Buy
TCI Chemicals (India) A5601 BSA [=N,O-Bis(trimethylsilyl)acetamide] [for Gas Chromatography] min. 80.0 % 5ML ₹2500 2022-05-26 Buy
TCI Chemicals (India) T0691 N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 mL × 8 / Reaction vial, capacity 2 mL × 8 [Trimethylsilylating Reagent, for NH2 compounds] 1KIT ₹4100 2022-05-26 Buy
TCI Chemicals (India) B0911 N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 mL × 8 / Reaction vial, capacity 2 mL × 8 min. 80.0 % 1KIT ₹5100 2022-05-26 Buy
TCI Chemicals (India) B0511 N,O-Bis(trimethylsilyl)acetamide [Trimethylsilylating Agent] min. 80.0 % 100ML ₹5900 2022-05-26 Buy
Sigma-Aldrich(India) 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 10ML ₹2219.13 2022-06-14 Buy
Sigma-Aldrich(India) 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 25ML ₹2316.55 2022-06-14 Buy
Sigma-Aldrich(India) 15269 N,O-Bis(trimethylsilyl)acetamide for GC derivatization, LiChropur?, ≥98.5% (GC) 5ML ₹4297.53 2022-06-14 Buy
Sigma-Aldrich(India) 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 100ML ₹6527.48 2022-06-14 Buy
Sigma-Aldrich(India) 8.18727 N,O-Bis(trimethylsilyl)acetamide for synthesis 25ML ₹8720.01 2022-06-14 Buy
Sigma-Aldrich(India) 15269 N,O-Bis(trimethylsilyl)acetamide for GC derivatization, LiChropur?, ≥98.5% (GC) 10X1ML ₹15209.13 2022-06-14 Buy
Sigma-Aldrich(India) 15269 N,O-Bis(trimethylsilyl)acetamide for GC derivatization, LiChropur?, ≥98.5% (GC) 25ML ₹16583.9 2022-06-14 Buy
Sigma-Aldrich(India) 8.18727 N,O-Bis(trimethylsilyl)acetamide for synthesis 100ML ₹16720 2022-06-14 Buy
Sigma-Aldrich(India) 1.09649 N,O-Bis(trimethylsilyl)acetamide for gas chromatography 25ML ₹25420 2022-06-14 Buy

Properties

Melting point :24 °C
Boiling point :71-73 °C35 mm Hg(lit.)
Density :0.832 g/mL at 20 °C(lit.)
vapor pressure :10 hPa (50 °C)
refractive index :n20/D 1.417(lit.)
Flash point :53 °F
storage temp. :Store below +30°C.
solubility :Miscible with many nonpolar and polar aprotic solvents.
form :Crystalline Powder, Crystals and/or Chunks
pka :5.82±0.50(Predicted)
Specific Gravity :0.832
color :Light yellow or beige to brown
Hydrolytic Sensitivity :7: reacts slowly with moisture/water
Sensitive :Moisture Sensitive
BRN :1306669
CAS DataBase Reference :10416-59-8(CAS DataBase Reference)
NIST Chemistry Reference :Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8)
EPA Substance Registry System :Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester (10416-59-8)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

N,O-Bis(trimethylsilyl)acetamide is used as a regioselective desulfation reagent as well as a preparatory agent for carbohydrate and alcohol trimethylsilyl ethers. It is also used for the derivatization of polar functional groups such as carboxylic acids, phenols, steroids, amines, alcohols, alkaloids and amides. It is employed in the formation of stable trimethylsilyl derivatives. Further, it is used in analytical chemistry for the derivatization of compounds in analysis to increase their volatility and to introduce the trimethylsilyl protecting group in organic synthesis. In addition to this, it is used in the protection of hydroxyl groups in natural products, functional groups in organic intermediates and derivatization reagent for gas chromatography-Mass spectral analysis of phenolic acids in fruits.

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