Trifluoroacetamide
![Trifluoroacetamide Structure](CAS/GIF/354-38-1.gif)
- CAS No.
- 354-38-1
- Chemical Name:
- Trifluoroacetamide
- Synonyms
- 2,2,2-TRIFLUOROACETAMIDE;Acetamide, 2,2,2-trifluoro-;CF3CONH2;Triflouroacetamide;Three-;TRIFLUOROACETAMIDE;2-TriflouroacetaMide;Trifluoroacetamide98%;Three fluoroacetaMide;2,2,2-Trifluoracetamid
- CBNumber:
- CB0291820
- Molecular Formula:
- C2H2F3NO
- Molecular Weight:
- 113.04
- MOL File:
- 354-38-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/24 17:31:20
Melting point | 65-70 °C (lit.) |
---|---|
Boiling point | 162.5 °C (lit.) |
Density | 1.4176 (estimate) |
Flash point | 162-164°C |
storage temp. | Store below +30°C. |
solubility | 460 g/L (20°C) |
form | Crystalline Powder or Crystals |
pka | 12.33±0.50(Predicted) |
color | White to pale yellow or beige |
PH | 3.6 (460g/l, H2O, 23℃) |
Water Solubility | 460 g/L (20 ºC) |
BRN | 1753625 |
InChIKey | NRKYWOKHZRQRJR-UHFFFAOYSA-N |
LogP | 0.725 at 23℃ and pH4.83 |
Dissociation constant | 0 at 23℃ |
CAS DataBase Reference | 354-38-1(CAS DataBase Reference) |
NIST Chemistry Reference | Acetamide, 2,2,2-trifluoro-(354-38-1) |
EPA Substance Registry System | Acetamide, 2,2,2-trifluoro- (354-38-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36-37/39 | |||||||||
RIDADR | 1759 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Harmful/Irritant | |||||||||
TSCA | T | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29241900 | |||||||||
NFPA 704 |
|
Trifluoroacetamide price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 8.14690 | 2,2,2-Trifluoroacetamide for synthesis | 354-38-1 | 10G | ₹2490 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 8.14690 | 2,2,2-Trifluoroacetamide for synthesis | 354-38-1 | 50G | ₹5650.01 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 144657 | Trifluoroacetamide 97% | 354-38-1 | 25G | ₹2024.28 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 144657 | Trifluoroacetamide 97% | 354-38-1 | 100G | ₹6224.38 | 2022-06-14 | Buy |
TCI Chemicals (India) | T0598 | Trifluoroacetamide min. 98.0 % | 354-38-1 | 25G | ₹3300 | 2022-05-26 | Buy |
Trifluoroacetamide Chemical Properties,Uses,Production
Chemical Properties
white to pale yellow or beige crystalline powder
Uses
2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.
Application
Trifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies.
Preparation
One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
10.1142/S1088424621500292
General Description
Trifluoroacetamide is a good quencher of tryptophan fluorescence.
Trifluoroacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
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GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
SRF Limited | +91-9810617574 +91-9650533660 | Haryana, India | 40 | 58 | Inquiry |
VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2096 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
Supplier | Advantage |
---|---|
GLR Innovations | 58 |
JSK Chemicals | 58 |
SRF Limited | 58 |
VASIN BIO LIFE SCIENCES PVT LTD | 58 |
A.J Chemicals | 58 |
CLEARSYNTH LABS LTD. | 58 |
TCI Chemicals (India) Pvt. Ltd. | 58 |
Otto Chemie Pvt. Ltd. | 58 |
Alfa Aesar | 58 |
Central Drug House(P) Ltd. | 58 |
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