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Trifluoroacetamide

Trifluoroacetamide Structure
CAS No.
354-38-1
Chemical Name:
Trifluoroacetamide
Synonyms
2,2,2-TRIFLUOROACETAMIDE;Acetamide, 2,2,2-trifluoro-;CF3CONH2;Triflouroacetamide;Three-;TRIFLUOROACETAMIDE;2-TriflouroacetaMide;Trifluoroacetamide98%;Three fluoroacetaMide;2,2,2-Trifluoracetamid
CBNumber:
CB0291820
Molecular Formula:
C2H2F3NO
Molecular Weight:
113.04
MOL File:
354-38-1.mol
MSDS File:
SDS
Modify Date:
2024/7/24 17:31:20

Trifluoroacetamide Properties

Melting point 65-70 °C (lit.)
Boiling point 162.5 °C (lit.)
Density 1.4176 (estimate)
Flash point 162-164°C
storage temp. Store below +30°C.
solubility 460 g/L (20°C)
form Crystalline Powder or Crystals
pka 12.33±0.50(Predicted)
color White to pale yellow or beige
PH 3.6 (460g/l, H2O, 23℃)
Water Solubility 460 g/L (20 ºC)
BRN 1753625
InChIKey NRKYWOKHZRQRJR-UHFFFAOYSA-N
LogP 0.725 at 23℃ and pH4.83
Dissociation constant 0 at 23℃
CAS DataBase Reference 354-38-1(CAS DataBase Reference)
NIST Chemistry Reference Acetamide, 2,2,2-trifluoro-(354-38-1)
EPA Substance Registry System Acetamide, 2,2,2-trifluoro- (354-38-1)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
RIDADR  1759
WGK Germany  3
Hazard Note  Harmful/Irritant
TSCA  T
HazardClass  8
PackingGroup  III
HS Code  29241900
NFPA 704
1
2

Trifluoroacetamide price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 8.14690 2,2,2-Trifluoroacetamide for synthesis 354-38-1 10G ₹2490 2022-06-14 Buy
Sigma-Aldrich(India) 8.14690 2,2,2-Trifluoroacetamide for synthesis 354-38-1 50G ₹5650.01 2022-06-14 Buy
Sigma-Aldrich(India) 144657 Trifluoroacetamide 97% 354-38-1 25G ₹2024.28 2022-06-14 Buy
Sigma-Aldrich(India) 144657 Trifluoroacetamide 97% 354-38-1 100G ₹6224.38 2022-06-14 Buy
TCI Chemicals (India) T0598 Trifluoroacetamide min. 98.0 % 354-38-1 25G ₹3300 2022-05-26 Buy
Product number Packaging Price Buy
8.14690 10G ₹2490 Buy
8.14690 50G ₹5650.01 Buy
144657 25G ₹2024.28 Buy
144657 100G ₹6224.38 Buy
T0598 25G ₹3300 Buy

Trifluoroacetamide Chemical Properties,Uses,Production

Chemical Properties

white to pale yellow or beige crystalline powder

Uses

2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.

Application

Trifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies.

Preparation

One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
10.1142/S1088424621500292

General Description

Trifluoroacetamide is a good quencher of tryptophan fluorescence.

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