Trifluoroacetic anhydride
![Trifluoroacetic anhydride Structure](CAS/GIF/407-25-0.gif)
- CAS No.
- 407-25-0
- Chemical Name:
- Trifluoroacetic anhydride
- Synonyms
- TFAA;trifluoroacetic;2,2,2-Trifluoroacetic anhydride;TRIFLUOROACETIC ACID ANHYDRIDE;TRIFLUORACETIC ANHYDRIDE;Trifluoroacetic anhy;TIFLUOROACETIC ANHYDRIDE;trimethylamine (TMA);uoroacetic anhydride;TRIFLUOROACETO ANHYDRIDE
- CBNumber:
- CB6853606
- Molecular Formula:
- C4F6O3
- Molecular Weight:
- 210.03
- MOL File:
- 407-25-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/24 13:33:21
Melting point | -65 °C (lit.) |
---|---|
Boiling point | 39.5-40 °C (lit.) |
Density | 1.511 g/mL at 20 °C (lit.) |
vapor pressure | 6.28 psi ( 20 °C) |
refractive index |
n |
Flash point | -26 °C |
storage temp. | 2-8°C |
solubility | Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile. |
form | Liquid |
pka | 0.43[at 20 ℃] |
Specific Gravity | 1.487 |
color | Clear |
Water Solubility | Hydrolysis |
Sensitive | Moisture Sensitive |
BRN | 746197 |
Stability | Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents. |
LogP | 0.79 at 25℃ |
CAS DataBase Reference | 407-25-0(CAS DataBase Reference) |
NIST Chemistry Reference | Acetic acid, trifluoro-, anhydride(407-25-0) |
EPA Substance Registry System | Acetic acid, trifluoro-, anhydride (407-25-0) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS05,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H314-H332-H412 | |||||||||
Precautionary statements | P273-P280-P301+P330+P331-P303+P361+P353-P304+P340+P312-P305+P351+P338+P310 | |||||||||
Hazard Codes | C,T | |||||||||
Risk Statements | 14-20-35-52/53-34-23/24/25 | |||||||||
Safety Statements | 26-36/37/39-43-45-61-9-8-28A-27 | |||||||||
RIDADR | UN 3265 8/PG 1 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | AJ9800000 | |||||||||
F | 3-10 | |||||||||
Hazard Note | Corrosive/Moisture Sensitive | |||||||||
TSCA | T | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | I | |||||||||
HS Code | 29159080 | |||||||||
Toxicity | skn-rbt 500 mg/24H SEV 28ZPAK -,91,72 | |||||||||
NFPA 704 |
|
Trifluoroacetic anhydride price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 91719 | Trifluoroacetic anhydride for GC derivatization, LiChropur?, ≥99.0% (GC) | 407-25-0 | 10ML | ₹7090.38 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 91719 | Trifluoroacetic anhydride for GC derivatization, LiChropur?, ≥99.0% (GC) | 407-25-0 | 10X1ML | ₹12892.58 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 91719 | Trifluoroacetic anhydride for GC derivatization, LiChropur?, ≥99.0% (GC) | 407-25-0 | 50ML | ₹24724.3 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 1.12513 | Trifluoroacetic anhydride for gas chromatography | 407-25-0 | 10ML | ₹18379.99 | 2022-06-14 | Buy |
TCI Chemicals (India) | T0433 | Trifluoroacetic Anhydride min. 98.0 % | 407-25-0 | 20ML | ₹1900 | 2022-05-26 | Buy |
Trifluoroacetic anhydride Chemical Properties,Uses,Production
Chemical Properties
Clear, colorless liquid
Uses
Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.
Safety Profile
A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit
Purification Methods
Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]
Trifluoroacetic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
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GLR Innovations | 58 |
ANJI BIOSCIENCES | 58 |
SURVIVAL TECHNOLOGIES LIMITED | 58 |
VGS SYNTHESIS PRIVATE LIMITED | 58 |
SRF Limited | 58 |
ALS INDIA LIFE SCIENCES | 58 |
JSK Chemicals | 58 |
Covalent Incorporation | 58 |
Vinergy International Pvt. Ltd. | 58 |
ASM Organics | 58 |
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