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Trifluoroacetic anhydride

Trifluoroacetic anhydride Structure
CAS No.
407-25-0
Chemical Name:
Trifluoroacetic anhydride
Synonyms
TFAA;trifluoroacetic;2,2,2-Trifluoroacetic anhydride;TRIFLUOROACETIC ACID ANHYDRIDE;TRIFLUORACETIC ANHYDRIDE;Trifluoroacetic anhy;TIFLUOROACETIC ANHYDRIDE;trimethylamine (TMA);uoroacetic anhydride;TRIFLUOROACETO ANHYDRIDE
CBNumber:
CB6853606
Molecular Formula:
C4F6O3
Molecular Weight:
210.03
MOL File:
407-25-0.mol
MSDS File:
SDS
Modify Date:
2024/7/24 13:33:21
Request For Quotation

Trifluoroacetic anhydride Properties

Melting point -65 °C (lit.)
Boiling point 39.5-40 °C (lit.)
Density 1.511 g/mL at 20 °C (lit.)
vapor pressure 6.28 psi ( 20 °C)
refractive index n20/D 1.3(lit.)
Flash point -26 °C
storage temp. 2-8°C
solubility Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
form Liquid
pka 0.43[at 20 ℃]
Specific Gravity 1.487
color Clear
Water Solubility Hydrolysis
Sensitive Moisture Sensitive
BRN 746197
Stability Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
LogP 0.79 at 25℃
CAS DataBase Reference 407-25-0(CAS DataBase Reference)
NIST Chemistry Reference Acetic acid, trifluoro-, anhydride(407-25-0)
EPA Substance Registry System Acetic acid, trifluoro-, anhydride (407-25-0)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H314-H332-H412
Precautionary statements  P273-P280-P301+P330+P331-P303+P361+P353-P304+P340+P312-P305+P351+P338+P310
Hazard Codes  C,T
Risk Statements  14-20-35-52/53-34-23/24/25
Safety Statements  26-36/37/39-43-45-61-9-8-28A-27
RIDADR  UN 3265 8/PG 1
WGK Germany  2
RTECS  AJ9800000
F  3-10
Hazard Note  Corrosive/Moisture Sensitive
TSCA  T
HazardClass  8
PackingGroup  I
HS Code  29159080
Toxicity skn-rbt 500 mg/24H SEV 28ZPAK -,91,72
NFPA 704
0
3 1

Trifluoroacetic anhydride price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 91719 Trifluoroacetic anhydride for GC derivatization, LiChropur?, ≥99.0% (GC) 407-25-0 10ML ₹7090.38 2022-06-14 Buy
Sigma-Aldrich(India) 91719 Trifluoroacetic anhydride for GC derivatization, LiChropur?, ≥99.0% (GC) 407-25-0 10X1ML ₹12892.58 2022-06-14 Buy
Sigma-Aldrich(India) 91719 Trifluoroacetic anhydride for GC derivatization, LiChropur?, ≥99.0% (GC) 407-25-0 50ML ₹24724.3 2022-06-14 Buy
Sigma-Aldrich(India) 1.12513 Trifluoroacetic anhydride for gas chromatography 407-25-0 10ML ₹18379.99 2022-06-14 Buy
TCI Chemicals (India) T0433 Trifluoroacetic Anhydride min. 98.0 % 407-25-0 20ML ₹1900 2022-05-26 Buy
Product number Packaging Price Buy
91719 10ML ₹7090.38 Buy
91719 10X1ML ₹12892.58 Buy
91719 50ML ₹24724.3 Buy
1.12513 10ML ₹18379.99 Buy
T0433 20ML ₹1900 Buy

Trifluoroacetic anhydride Chemical Properties,Uses,Production

Chemical Properties

Clear, colorless liquid

Uses

Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.

Safety Profile

A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit

Purification Methods

Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]

Trifluoroacetic anhydride Preparation Products And Raw materials

Raw materials

DICHLOROACETIC ANHYDRIDE Trifluoroacetic acid

Preparation Products

1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINE 2-CYANO-4-PYRIDINE CARBOXYLIC ACID 2-Hydroxy-4-(trifluoromethyl)pyrimidine 5-Bromo-2-hydroxymethylpyridine 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile
2-Chloro-4-(trifluoromethyl)pyrimidine [BIS(TRIFLUOROACETOXY)IODO]PENTAFLUOROBENZENE 6-Aminobenzothiazole 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINIC ACID 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide
(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine 2,6-DICHLORO-4-ISOCYANATOPYRIDINE Ethyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate
3-(Trifluoromethyl)pyrazole 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE Chlorfenapyr (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
4-CHLORO-ALPHA-[METHYL(TRIFLUOROACETYL)AMINO]-BENZENEACETIC ACID 2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97% 3-Nitroisonicotinic acid Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 5-Iodo-2,4-dimethoxypyrimidine N10-(TRIFLUOROACETYL)PTEROIC ACID 3-Amino-4-nitrobenzitrifluoride 2-(TRIFLUOROACETYL)THIOPHENE
2-BROMO-4-(TRIFLUOROMETHYL)PYRIMIDINE 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde Epirubicin 2-(Bromomethyl)-6-methylpyridine 5-Bromopyridine-2-carbaldehyde
ETHYL 5-AMINO-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine 3-CHLORO-5-NITROPYRIDINE [Bis(trifluoroacetoxy)iodo]benzene
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Trifluoroacetic anhydride Suppliers

Global( 537)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
GLR Innovations +91 9891111994 New Delhi, India 4542 58 Inquiry
ANJI BIOSCIENCES +91-9000100077 +91-9000100077 Hyderabad, India 430 58 Inquiry
SURVIVAL TECHNOLOGIES LIMITED +91 8108285261 Gujarat, India 294 58 Inquiry
VGS SYNTHESIS PRIVATE LIMITED +91-9866975588 +91-9866975588 Hyderabad, India 1818 58 Inquiry
SRF Limited +91-9810617574 +91-9650533660 Haryana, India 40 58 Inquiry
ALS INDIA LIFE SCIENCES +91-8977036379 +91-8977036379 Hyderabad, India 1879 58 Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
Covalent Incorporation +91-9033666099 +91-9033666099 Gujarat, India 50 58 Inquiry
Vinergy International Pvt. Ltd. 91-22-66537221 Maharashtra, India 28 58 Inquiry
ASM Organics 91-9866122393 Andhra Pradesh, India 1188 58 Inquiry
Supplier Advantage
GLR Innovations 58
ANJI BIOSCIENCES 58
SURVIVAL TECHNOLOGIES LIMITED 58
VGS SYNTHESIS PRIVATE LIMITED 58
SRF Limited 58
ALS INDIA LIFE SCIENCES 58
JSK Chemicals 58
Covalent Incorporation 58
Vinergy International Pvt. Ltd. 58
ASM Organics 58

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Trifluoroacetic anhydride Spectrum

Trifluoroacetic anhydride(407-25-0)MSTrifluoroacetic anhydride(407-25-0)13CNMRTrifluoroacetic anhydride(407-25-0)IR1

407-25-0(Trifluoroacetic anhydride)Related Search:

Glutaric anhydride Ethyl trifluoroacetate Succinic anhydride Isatoic Anhydride Trifluoromethanesulfonic anhydride
Phthalic anhydride CIS-BUTENEDIOIC ANHYDRIDE Trifluoroacetic acid Sodium trifluoroacetate Potassium trifluoroacetate
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Acetic anhydride 2,2,2-TRIFLUOROETHYL METHYL ETHER 2-Fluoroethanol Trifluoroacetic Acid Anhydride
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TRIFLUOROACETO ANHYDRIDE Trifluoroacetic acid anhydride (TFAH) RIFLUOROACETIC ANHYDRIDE Trifluoroacetic anhydride 10g [407-25-0] Trifluoroacetic anhydride, min. 98% trifluoroacetyl 2,2,2-trifluoroacetate Trifluoroacetic anhydride, 99+% 100GR Trifluoroacetic anhydride, 99+% 25GR Trifluoracetic anhydride, min. 98% Bis(2,2,2-trifluoroacetic acid)anhydride Bis(trifluoroacetic acid) anhydride Di(trifluoroacetic)anhydride Trifluoroacetyltrifluoroacetate Trifluoroethanoicanhydride TRIFLUOROACETIC ANHYDRIDE BIS(TRIFLUOROACETIC) ANHYDRIDE Triflyuoroacetic anhydride Aceticacid,trifluoro-,anhydride Anhydrid kyseliny trifluoroctove anhydridkyselinytrifluoroctove Hexafluoroacetic anhydride hexafluoroaceticanhydride Perfluoroacetic anhydride perfluoroaceticanhydride TRIFLUOROACETIC ANHYDRIDE, REAGENTPLUS, >=99% TRIFLUOROACETIC ANHYDRIDE, DERIVATIZA-TI ON REAGENT TRIFLUOROACETIC ANHYDRIDE REAGENTPLUS(& TrifluoroaceticAnhydride/Tfaa/Tfah/Trifluoroaceticanhydride TrifluoroaceticAnhydride/Tfaa Trifluoroacetic anhydride, 99+% Trifluoraceticanhydride,min.98% TRIFLUOROACETICANHYDRIDE,REAGENT Trifluoressigsureanhydrid Perfluoracetic anhydride TRIFLUOROACETIC ANHYDRIDE: 99.5% TRIFLUOROACETIC ANHYDRIDE FOR SYNTHESIS TRIFLUOROACETIC ANHYDRIDE FOR GAS CHROMA Trifluoroacetic anhydride 99% TRIFLUOROACETIC ANHYDRINE TFAH)Trifluoroacetic anhyd 1,1,1,5,5,5-Hexafluoro-3-oxapentan-2,4-dione, Perfluoro(3-oxapentan-2,4-dione), 2,2,2-Trifluoroethanoic anhydride Aceticacid, 2,2,2-trifluoro-, 1,1'-anhydride Three fluorineacetic anhydride trimethylamine (TMA) Trifluoroacetic anhydride ReagentPlus(R), >=99% Trifluoroacetyl 2,2,2-trifluoroacetate (Trifluoroacetic anhydride) Trifluoroacetic anhydride≥ 99% (GC) TFAA Trifluoroacetic acid anhydride trifluoro-aceticacianhydride Trifluoroacetyl anhydride trifluoroacetylanhydride Trifluoroacetic Anhydride > Trifluoroacetic Anhydride (Reagent), Fisher Chemical Trifluoroacetic Anhydride, 99&plus uoroacetic anhydride Trifluoroacetic anhydride 407-25-0 fiona trifluorocytic anhydride fiona TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%