ChemicalBook > Product Catalog >Biochemical Engineering >Biochemical Reagents >Biological Dyes >Isatoic Anhydride
Isatoic Anhydride
- CAS No.
- 118-48-9
- Chemical Name:
- Isatoic Anhydride
- Synonyms
- 1H-BENZO[D][1,3]OXAZINE-2,4-DIONE;Isatoic;2-(carboxyamino)-benzoicacicyclicanhydride;BENZOXAZINEDIONE;4H-3,1-Benzoxazine-2,4(1H)-dione;1,2-Dihydro-3,1-benzoxazine-2,4-dione;4H-3;Isatoic Ac;4(1H)-dione;1-Benzoxazine-2
- CBNumber:
- CB9238051
- Molecular Formula:
- C8H5NO3
- Molecular Weight:
- 163.13
- MOL File:
- 118-48-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/30 21:22:42
| Melting point | 233 °C (dec.) (lit.) |
|---|---|
| Boiling point | 290.19°C (rough estimate) |
| Density | 1,52 g/cm3 |
| vapor density | 5.6 (vs air) |
| refractive index | 1.5510 (estimate) |
| Flash point | 308 °C |
| storage temp. | Store below +30°C. |
| solubility | 0.3g/l |
| form | Powder |
| pka | 11.06±0.20(Predicted) |
| color | Beige to brown |
| Water Solubility | decomposes |
| Sensitive | Moisture Sensitive |
| BRN | 136786 |
| LogP | 0.978 (est) |
| CAS DataBase Reference | 118-48-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Isatoic anhydride(118-48-9) |
| EPA Substance Registry System | 2H-3,1-Benzoxazine-2,4(1H)-dione (118-48-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H319 | |||||||||
| Precautionary statements | P261-P264-P272-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36-43 | |||||||||
| Safety Statements | 24-26-37 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | DM3100000 | |||||||||
| F | 3 | |||||||||
| Autoignition Temperature | >600 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 6400 mg/kg LD50 dermal Rabbit > 2000 mg/kg | |||||||||
| NFPA 704 |
|
Isatoic Anhydride price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I12808 | Isatoic anhydride 96% | 118-48-9 | 100G | ₹1959.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I12808 | Isatoic anhydride 96% | 118-48-9 | 500G | ₹4459.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.04784 | Isatoic anhydride for synthesis | 118-48-9 | 100G | ₹4720 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.04784 | Isatoic anhydride for synthesis | 118-48-9 | 500G | ₹37990 | 2022-06-14 | Buy |
| ALFA India | ALF-A14603-36 | Isatoic anhydride, 97% | 118-48-9 | 500g | ₹7043 | 2022-05-26 | Buy |
Isatoic Anhydride Chemical Properties,Uses,Production
Chemical Properties
BEIGE TO BROWN POWDER
Uses
Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.
Preparation
Phosphorus tribromide (0.035 mol) was added to a solution of N-carbethoxy- or N-carbobenzoxy-anthranilic acid (0.1 mol;prepared by coupling anthranilic acid with the corresponding carbalkoxy chloride in the usual way) in anhydrous diethyl ether (100 mL). After 24 h at room temperature, isatoic anhydride had separated as a microcrystalline product. It was collected by filtration, washed with dry diethyl ether, and recrystallized from ethanol. Yield ca. 90%.
Definition
A bicyclic molecule composed of a benzene ring attached at the oand mpositions to a heterocyclic ring. It forms useful anthranilic acid derivatives by reaction with hydrogen.
Purification Methods
Recrystallise it from EtOH or 95% EtOH (30mL/g) or dioxane (10mL/g) and dry it in a vacuum. [Wagner & Fegley Org Synth Coll Vol III 488 1955, Ben-Ishai & Katchalski J Am Chem Soc 74 3688 1952, UV: Zentmyer & Wagner J Org Chem 14 967 1949, Beilstein 27 II 299, 27III/IV 3330.]
Isatoic Anhydride Preparation Products And Raw materials
Raw materials
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Global( 447)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SALVI CHEMICAL | +91-9321313096 +91-9321313096 | Mumbai, India | 26 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Anshul Specialty Molecules Pvt. Ltd | +91-2226865566 +91-2226865566 | Mumbai, India | 23 | 58 | Inquiry |
| Moleculochem | 9811853366 | New Delhi, India | 25 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Molkem Chemicals Pvt. Ltd. | 91-79-61202500 | Gujarat, India | 199 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SALVI CHEMICAL | 58 |
| JSK Chemicals | 58 |
| Anshul Specialty Molecules Pvt. Ltd | 58 |
| Moleculochem | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Central Drug House(P) Ltd. | 58 |
| Molkem Chemicals Pvt. Ltd. | 58 |
118-48-9(Isatoic Anhydride)Related Search:
6-METHYL ISATINIC ANHYDRIDE
N-methylisatoic anhydride
4-NITRO-ISATOIC ANHYDRIDE
Isatoic Anhydride
5-Bromoisatoic anhydride
6-CHLOROISATIN
3-[2-(Diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione
5-Fluoroisatonic anhydride
6-Fluoroisatoic anhydride
4-Chloro-isatoic anhydride
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2,4-Dioxo-1,2-dihydro-4H-3,1-benzoxazine
4H-3,1-Benzoxazin-2,4-(1H)-dion
4H-3,1-Benzoxazin-2,4(1H)-dion
Anthranilic acid, N-carboxy-, cyclic anhydride
Benzoic acid, 2-(carboxyamino)-, cyclic anhydride
Benzoicacid,2-(carboxyamino)-,cyclicanhydride
Isato acid anhydride
1,2-dihydro-4h-3,1-benzoxazine-2,4-dione
1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2,4-DIONE
3,1-BENZOXAZINE-2,4(1H)-DIONE
2H-3,1-BENZOXAZINE-2,4(1H)-DIONE
LABOTEST-BB LT00053651
ISATOLC ANHYDRIDE
ISATOIC ANHYDRIDE
ANTHRANILIC ACID N-CARBOXYLIC ACID ANHYDRIDE
TIMTEC-BB SBB003928
N-CARBOXYANTHRANILIC ACID CYCLIC ANHYDRIDE
2H-3,1-benzoxazine-2,4(1H)-dio
N-carboxyanthranilic acid anhydride
1,4-Dihydro-2H-3,1-benzoxazine-2,4-dione
Isatoic anhydride,98%
Isatoic anhydride, 98% 100GR
3,1-Benzoxazine-2,4(1H)-dione, Anthranilic acid N-carboxylic acid anhydride
1H-3,1-Benzoxazine-2,4-dione
Isatoic acid anhydride
isatoicacidanhydride
Isatonicanhydride
Isatosαureanhydrid
n-carboxy-anthranilicacicyclicanhydride
N-Carboxyanthranilicanbydride
n-carboxyanthranilicanhydride
1H-Benz[d][1,3]oxazine-2,4-dione
2-(CarboxyaMino)benzoic Acid Cyclic Anhydride
Isatoic Ac
ISATOIC ANHYDRIDE FOR SYNTHESIS
Isatoic anhydrate
1H-3,1-benzoxazine-2,4-quinone
1-Benzoxazine-2
4(1H)-dione
4H-3
IsatoicAnhydride>
Isatin anhydride
Isatoic anhydride, 97%,
1,2-Dihydro-3,1-benzoxazine-2,4-dione
2-(carboxyamino)-benzoicacicyclicanhydride
4H-3,1-Benzoxazine-2,4(1H)-dione
1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
BENZOXAZINEDIONE
Isatoic
Isatoic anhydride (6CI)
Isatioc anhydride
satoic Anhydride
118-48-9
C6H4C2HNO3
CC6H4NHCOO
C8H5NO3
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