Metformin hydrochloride
- CAS No.
- 1115-70-4
- Chemical Name:
- Metformin hydrochloride
- Synonyms
- METFORMIN HCL;GLUCOPHAGE;big;MetforMin HCl USP;Metformin hydrochloride CRS;Medet;DIABEX;meguan;Nelbis;Metrion
- CBNumber:
- CB6222671
- Molecular Formula:
- C4H12ClN5
- Molecular Weight:
- 165.62
- MOL File:
- 1115-70-4.mol
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 223-226 °C(lit.) |
|---|---|
| Density | 1.36[at 20℃] |
| vapor pressure | 0.001Pa at 25℃ |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, slightly soluble in alcohol, practically insoluble in acetone and in methylene chloride |
| pka | 12.4[at 20 ℃] |
| form | Powder |
| color | White |
| Water Solubility | Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM). |
| λmax | 233nm(H2O)(lit.) |
| Merck | 14,5938 |
| BCS Class | 3 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. |
| InChIKey | OETHQSJEHLVLGH-UHFFFAOYSA-N |
| LogP | -3.5 at 20℃ |
| CAS DataBase Reference | 1115-70-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-36/38-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 26-36-45-36/37-16-7 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DU1800000 | |||||||||
| HS Code | 29252900 | |||||||||
| Toxicity | LD50 in rats (mg/kg): 1000 orally, 300 s.c. (Rx Bulletin) | |||||||||
| NFPA 704 |
|
Metformin hydrochloride price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1084 | Metformin hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 1115-70-4 | 500MG | ₹9991.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M-072 | Metformin hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 1115-70-4 | 1ML | ₹13167 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D150959 | 1,1-Dimethylbiguanide hydrochloride 97% | 1115-70-4 | 5G | ₹11853.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 317240 | Metformin - CAS 1115-70-4 - Calbiochem An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. | 1115-70-4 | 5G | ₹12630.01 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M2009 | Metformin Hydrochloride | 1115-70-4 | 25G | ₹5300 | 2022-05-26 | Buy |
Metformin hydrochloride Chemical Properties,Uses,Production
Description
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.
Chemical Properties
Crystalline Solid
Uses
Metformin hydrochloride may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations and human plasma samples by analytical techniques.
Definition
ChEBI: A hydrochloride resulting from the reaction of metformin with one molar equivalent of hydrogen chloride.
General Description
1,1-Dimethylbiguanide hydrochloride (metformin) is a strong base. It forms well defined salts and possessing excellent coordination capacity with transition metals, forming highly colored bidentate chelate complexes. Metformin (MET) exists in various forms: diprotonated (H2MET)2+ in strong acidic solution, monoprotonated (HMET)+ in weak acid, MET in neutral and deprotonated (MET)- in strong alkali solution. It is an oral antidiabetic drug. Pharmacokinetics of metformin has been studied. Determination of metformin in human plasma has been described by simple HPLC-UV method. Metformin is reported to increase plasma active glucagon-like peptide-1 (GLP-1) in humans.
Biological Activity
Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines.
Metformin hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANWITA APIS | +919000311012 | Hyderabad, India | 198 | 58 | Inquiry |
| GRINDLAYS PHARMACEUTICALS PRIVATE LIMITED | +91-91-22-25278801 +91-2225278801 | Mumbai, India | 83 | 58 | Inquiry |
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| Vivimed Labs Ltd | +914066086608 | Telangana, India | 61 | 58 | Inquiry |
| Ipca Laboratories Ltd | +91-2262105000 +91-2262105000 | Maharashtra, India | 61 | 58 | Inquiry |
| Smruthi Organics Limited | +91-9881467770 +91-9822910599 | Maharashtra, India | 24 | 58 | Inquiry |
| Soujanya Life Sciences | +91-9717304919 +91-9717304919 | Mumbai, India | 17 | 58 | Inquiry |
| Harman Finochem Ltd | +91-2226528080 +91-2226528080 | Maharashtra, India | 37 | 58 | Inquiry |
| Abhilash Chemicals And Pharmaceuticals Pvt. Ltd. | 91 9790772186 | Tamil Nadu, India | 1 | 58 | Inquiry |
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