Diltiazem hydrochloride
Diltiazem hydrochloride
- CAS:
- 33286-22-5
- MF:
- C22H27ClN2O4S
- MW:
- 450.98
Suppliers by country/region
- India(70)
- CHINA(197)
- United States(59)
- United Kingdom(26)
- Canada(6)
- France(3)
- Europe(3)
- Germany(7)
- Switzerland(5)
- Czech Republic(3)
- Japan(3)
- Italy(5)
- Belgium(3)
- Israel(2)
- Slovenia(1)
- South Korea(4)
- Austria(1)
- The Netherlands(1)
- Finland(2)
- Poland(2)
- Brazil(4)
- Indonesia(1)
- United Arab Emirates(1)
- Iran(1)
Company Type
Properties
- Melting point:
- 212-214 °C
- alpha
- D24 +98.3 ± 1.4° (c = 1.002 in methanol)
- Density
- 1.30 g/cm3
- refractive index
- 118 ° (C=1, H2O)
- Flash point:
- 2℃
- storage temp.
- 2-8°C
- solubility
- Freely soluble in water, in methanol and in methylene chloride, slightly soluble in anhydrous ethanol.
- form
- Powder
- color
- White to off-white
- PH
- pH (10g/l, 25℃) : 4.3~5.3
- Water Solubility
- soluble
- Merck
- 13,3226
- BRN
- 4228706
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P301+P312+P330
- Hazard Codes
- Xn,Xi,F
- Risk Statements
- 22-40-36/37/38-36-20/21/22-11
- Safety Statements
- 36-45-36/37-26-16
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- DL0310000
- F
- 8-10
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29349990
- Toxicity
- LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972)
Use
Diltiazem hydrochloride was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.
70 India supplier list of "Diltiazem hydrochloride"
- Product Name:Diltiazem hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Diltiazem hydrochloride
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Diltiazem hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:DILTIAZEM HCL USP
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: New Delhi,INDIA
- Product Name:Diltiazem hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Diltiazem hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Diltiazem hydrochloride
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Diltiazem hydrochloride
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Diltiazem hydrochloride
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Hyderabad,INDIA
- Product Name:DILTIAZEM HYDROCHLORIDE 54.0%, 40% SR PELLETS
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA