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Prostratin, PKC activator

Prostratin, PKC activator Structure
CAS No.
60857-08-1
Chemical Name:
Prostratin, PKC activator
Synonyms
SA 101A;NSC 623310;CCRIS 6292;PROSTRATIN;Prostatin >99%;Stillingia Facto;13-O-Acetylphorbol;Prostratin, PKC activator;12-DEOXYPHORBOL 13-ACETATE;13-O-Acetyl-12-deoxyphorbol
CBNumber:
CB0150130
Molecular Formula:
C22H30O6
Molecular Weight:
390.47
MOL File:
60857-08-1.mol
MSDS File:
SDS
Modify Date:
2023/8/4 0:20:14

Prostratin, PKC activator Properties

Melting point 216-219℃
Boiling point 550.5±50.0 °C(Predicted)
Density 1.31
storage temp. -20°C
solubility Soluble in DMSO at 30mg/ml
form white powder
pka 11.40±0.70(Predicted)
color Off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

WGK Germany  3
HS Code  2916200090

Prostratin, PKC activator price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) P0077 Prostratin ≥98% (HPLC) 60857-08-1 1MG ₹12773.5 2022-06-14 Buy
Sigma-Aldrich(India) P0077 Prostratin ≥98% (HPLC) 60857-08-1 5MG ₹51765.15 2022-06-14 Buy
Product number Packaging Price Buy
P0077 1MG ₹12773.5 Buy
P0077 5MG ₹51765.15 Buy

Prostratin, PKC activator Chemical Properties,Uses,Production

Description

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC50 value of ~0.5 μM. Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.

Definition

ChEBI: A natural product found in Euphorbia fischeriana.

Prostratin, PKC activator Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 63)Suppliers
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Henan Bao Enluo International TradeCo.,LTD +86-17331933971 +86-17331933971 China 2503 58 Inquiry
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career henan chemical co +86-0371-86658258 +8613203830695 China 29824 58 Inquiry
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Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826 China 25009 65 Inquiry
RD International Technology Co., Limited 18024082417 China 9268 58 Inquiry
SA 101A Prostatin >99% 12-Deoxyphorbol 13-Acetate, dPAc (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl- 13-O-Acetyl-12-deoxyphorbol PROSTRATIN (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl- 5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 13-O-Acetylphorbol NSC 623310 Stillingia Facto CCRIS 6292 12-DEOXYPHORBOL 13-ACETATE (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aβ,7bα-dihydroxy-9aα-acetoxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benzo[1,2-e]azulene-5-one (1aR)-9aα-Acetoxy-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one Prostratin, PKC activator 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bR,8R,9aS)- Prostratin, PKC activator USP/EP/BP (1aR,1bS,4aR,7aS,7bR,8R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate 60857-08-1 Activator Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators