ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Esters >Carboxylic Acid Esters >PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL 12-MYRISTATE 13-ACETATE
- CAS No.
- 16561-29-8
- Chemical Name:
- PHORBOL 12-MYRISTATE 13-ACETATE
- Synonyms
- TPA;12-O-TETRADECANOYLPHORBOL 13-ACETATE;Recombinant Human Tissue Plasminogen Activator;phorbol ester;factora1;,9aalpha))-;Cocarcinogen A1;Cocarcinogen C3;pma(tumorpromoter);factora1(crotonoil)
- CBNumber:
- CB2376433
- Molecular Formula:
- C36H56O8
- Molecular Weight:
- 616.83
- MOL File:
- 16561-29-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/3 15:02:28
| Melting point | 65-79oC |
|---|---|
| Boiling point | 571.87°C (rough estimate) |
| Density | 1.17±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.4900 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: DMSO solutions can be stored dark at −20°C for at least six months.soluble |
| pka | 11.19±0.70(Predicted) |
| form | Fine Crystalline Powder |
| color | Off-white to light yellow |
| Water Solubility | Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water. |
| Sensitive | Light Sensitive |
| BRN | 2407201 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| InChIKey | PHEDXBVPIONUQT-RGYGYFBISA-N |
| CAS DataBase Reference | 16561-29-8(CAS DataBase Reference) |
| EPA Substance Registry System | 12-O-Tetradecanoylphorbol 13-acetate (16561-29-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H314-H317-H334-H351 | |||||||||
| Precautionary statements | P202-P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 38-36/37/38 | |||||||||
| Safety Statements | 36/37-26 | |||||||||
| RIDADR | 2928 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QH4377000 | |||||||||
| F | 8-10 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29153900 | |||||||||
| Toxicity | Diesters of phorbol, particularly 12-O-tetradecanoylphorbol 13-acetate, also known as phorbol myristate acetate, have been identified as the potent, highly lipophilic tumor-promoting components in croton oil. They are potent promoters of skin tumors in vivo and have been shown to transform cultured fibroblasts and embryonic cells previously exposed to polycyclic aromatic hydrocarbon carcinogens in vitro. The structure of phorbol, the parent alcohol is shown below. Phorbol esters also have important effects on leukocytes and on the immune system of the intact animal. There appears to be a specific receptor for phorbol esters on T cells, a finding that may account for the selective toxicity of phorbol esters for T cells. The mechanism of tumor promotion by phorbol esters is still largely unknown, but findings suggest an initial cell membrane interaction (often with stimulation of second messenger synthesis and increased protein kinase activity), with subsequent effects on nuclear regulatory events. | |||||||||
| NFPA 704 |
|
PHORBOL 12-MYRISTATE 13-ACETATE price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P8139 | Phorbol 12-myristate 13-acetate ≥99% (TLC), film or powder | 16561-29-8 | 1MG | ₹12654.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P8139 | Phorbol 12-myristate 13-acetate ≥99% (TLC), film or powder | 16561-29-8 | 5MG | ₹32345.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P8139 | Phorbol 12-myristate 13-acetate ≥99% (TLC), film or powder | 16561-29-8 | 10MG | ₹60013.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P8139 | Phorbol 12-myristate 13-acetate ≥99% (TLC), film or powder | 16561-29-8 | 25MG | ₹127475.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P1585 | PMA for use in molecular biology applications, ≥99% (HPLC) | 16561-29-8 | 1MG | ₹12546.18 | 2022-06-14 | Buy |
PHORBOL 12-MYRISTATE 13-ACETATE Chemical Properties,Uses,Production
Chemical Properties
white to off-white solid
Uses
4β-Phorbol 12-Myristate 13-Acetate is used in the activation of certain pyruvate kinases as well as protein kinases.
General Description
White crystals.
Air & Water Reactions
Practically water insoluble.
Reactivity Profile
PHORBOL 12-MYRISTATE 13-ACETATE is sensitive to acids and alkalis. .
Fire Hazard
Flash point data for PHORBOL 12-MYRISTATE 13-ACETATE are not available; however, PHORBOL 12-MYRISTATE 13-ACETATE is probably combustible.
Biological Activity
Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a K i value of 2.6 nM as measured by displacement of [ 3 H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.
PHORBOL 12-MYRISTATE 13-ACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 241)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3777 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12447 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20294 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9338 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
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13-o-acetylphorbol12-myristate
4)benz(1,2-e)azulen-5-one9a-acetate,(+)-ethyl-5h-cyclopropa(
5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-beta,1b-alpha,4,4a,7a-beta,7b,
4BETA-PHORBOL 12-MYRISTATE 13-ACETATE
4BETA,9ALPHA,12BETA,13ALPHA,20-PENTA-HYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
4ALPHA,9ALPHA,12BETA,13ALPHA,20-PENTAHYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
(1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
12-TETRADECANOYL PHORBOL 13-ACETATE
PHORBOL 12-MYRISTATE 13-ACETATE, SYNTHET IC
PHORBOL 12-MYRISTATE 13-ACETATE,*MOLECUL AR BIOLOGY
PHORBOL 12-MYRISTATE 13-ACETATE FROM &
Tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa3,4benz1,2-eazulen-9-yl ester
4B-PHORBOL-12-MYRISTATE-13-ACETATE
2-ORTHO-TETRADECANOYL-PHORBOL-13-ACETATE
O-TETRADECANOYLPHORBOL-13-ACETATE
12-ORTHO-TETRADECANOYLPHORBOL-13-ACETATE
12-O-Tetradecanoylphorbol 13-acetate, PMA, TPA, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
Phorbol 12-myristate 13-acetate,99%
Phorbol 12-myristate 13-acetate,97%
PHORBOL(12-MYRISTOYL-13-ACETYL) ANALYTICAL GRADE
Phorbol 12-myristate 13-acetate,12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA
Phorbol 12-Myristate 13-Acetate >99.5%
Phorbol-12-Myristate-13-acetate / 12-Tetradecanoyl phorbol-13-acetate, TPA
PMA, TPA, Cocarcinogen A1
12-O-TETRADECANOYL PHORBOL-13-ACETATE;COCARCINOGEN A1; COCARCINOGEN C3
Cocarcinogen A1
Cocarcinogen C3
(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-acetoxy-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
12-O-tetradecanoyl phorbol-13-acetate(CAS：16561-29-8)
4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
PHORBOL 12-MYRISTATE 13-ACETATE, SYN
(1AR,1bS,4aR,7aS,7bS,8R,9R,9aS)
-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
-9a-acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)
InSolution? Phorbol-12-myristate-13-acetate
PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL (12-MYRISTOYL-13-ACETYL)
8,9,9a-decahydro-4a-alpha,7b-beta,9-alpha,9a-beta-tetrahydroxy-3-(hydroxymethy
abeta,7balpha,9beta,9aalpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetram
a-tetramethyl-5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,9a-acetate
-e)azulen-9-ylester,(1ar-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta
factora1
factora1(crotonoil)
factora1[crotonoil]
hydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1h-cyclopropa(3,4)benz(1,2
myristicacid,9-esterwith1,1a-alpha,1b-beta,4,4a,7a-alpha,7b,8,9,9a-decahydr
myristicacid,9-esterwith1,1aalpha,1bbeta,4,4a,7aalpha,7b,8,9,9a-decahydro-4
o-4a-beta,7b-alpha,9-beta,9a-alpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-alph
pentahydroxy-tigliadienone-monoacetate(c)monomyristate(b)
phorbol12-tetradecanoate13-acetate
phorbolacetate,myristate
phorbolmonoacetatemonomyristate
phorbolmyristateacetate
pma(tumorpromoter)
tetradecanoicacid,9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-di
tetradecanoylphorbolacetate
,9aalpha))-
1,6,8-beta-tetramethyl-l)-9a-acetate9-myristate