PHORBOL 12-MYRISTATE 13-ACETATE
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PHORBOL 12-MYRISTATE 13-ACETATE 속성
- 녹는점
- 65-79oC
- 끓는 점
- 571.87°C (rough estimate)
- 밀도
- 1.17±0.1 g/cm3 (20 ºC 760 Torr)
- 굴절률
- 1.4900 (estimate)
- 저장 조건
- -20°C
- 용해도
- DMSO: DMSO 용액은 최소 6개월 동안 '20'C에서 어두운 상태로 보관할 수 있습니다.
- 산도 계수 (pKa)
- 11.19±0.70(Predicted)
- 물리적 상태
- 미세 결정성 분말
- 색상
- 황백색에서 밝은 노란색까지
- 수용성
- 메탄올에 매우 잘 녹고 DMSO, 클로로포름, 에탄올 또는 아세톤, 에테르, 에틸 아세테이트, DMF 또는 아세토니트릴에 잘 녹습니다. 물에 불용성.
- 감도
- Light Sensitive
- BRN
- 2407201
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 2개월 동안 보관할 수 있습니다.
- InChIKey
- PHEDXBVPIONUQT-RGYGYFBISA-N
- CAS 데이터베이스
- 16561-29-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 38-36/37/38 | ||
안전지침서 | 36/37-26 | ||
유엔번호(UN No.) | 2928 | ||
WGK 독일 | 3 | ||
RTECS 번호 | QH4377000 | ||
F 고인화성물질 | 8-10 | ||
위험 등급 | 6.1(a) | ||
포장분류 | II | ||
HS 번호 | 29153900 | ||
유해 물질 데이터 | 16561-29-8(Hazardous Substances Data) | ||
독성 | Diesters of phorbol, particularly 12-O-tetradecanoylphorbol 13-acetate, also known as phorbol myristate acetate, have been identified as the potent, highly lipophilic tumor-promoting components in croton oil. They are potent promoters of skin tumors in vivo and have been shown to transform cultured fibroblasts and embryonic cells previously exposed to polycyclic aromatic hydrocarbon carcinogens in vitro. The structure of phorbol, the parent alcohol is shown below. Phorbol esters also have important effects on leukocytes and on the immune system of the intact animal. There appears to be a specific receptor for phorbol esters on T cells, a finding that may account for the selective toxicity of phorbol esters for T cells. The mechanism of tumor promotion by phorbol esters is still largely unknown, but findings suggest an initial cell membrane interaction (often with stimulation of second messenger synthesis and increased protein kinase activity), with subsequent effects on nuclear regulatory events. |
PHORBOL 12-MYRISTATE 13-ACETATE C화학적 특성, 용도, 생산
화학적 성질
white to off-white solid용도
4β-Phorbol 12-Myristate 13-Acetate is used in the activation of certain pyruvate kinases as well as protein kinases.일반 설명
White crystals.공기와 물의 반응
Practically water insoluble.반응 프로필
PHORBOL 12-MYRISTATE 13-ACETATE is sensitive to acids and alkalis. .화재위험
Flash point data for PHORBOL 12-MYRISTATE 13-ACETATE are not available; however, PHORBOL 12-MYRISTATE 13-ACETATE is probably combustible.생물학적 활성
Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a K i value of 2.6 nM as measured by displacement of [ 3 H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.PHORBOL 12-MYRISTATE 13-ACETATE 준비 용품 및 원자재
원자재
준비 용품
PHORBOL 12-MYRISTATE 13-ACETATE 공급 업체
글로벌( 242)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3772 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12495 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20291 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9284 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 |
sale02@cqherb.com | CHINA | 376 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
PHORBOL 12-MYRISTATE 13-ACETATE 관련 검색:
1,2-DIOCTANOYL-SN-GLYCEROL
Prostratin, PKC activator
1-OLEOYL-2-ACETYL-SN-GLYCEROL
(-)-INDOLACTAM V
INGENOL 3,20-DIBENZOATE
(+)-7-OCTYLINDOLACTAM V
FTT
PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL
4Α-PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL 13-ACETATE
4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%,4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL,4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL-12-MYRISTATE-13-ACETATE, [20-3H(N)]
PHORBOL 12-MYRISTATE-13-ACETATE-4-O-METHYL ETHER,PHORBOL 12-MYRISTATE 13-ACETATE 4-O-METHYL ETHER, 4BETA,PHORBOL 12-MYRISTATE-13-ACETATE-4-O- &
PHORBOL 16-HYDROXY 12-PALMITATE 13-ACETATE
Phorbol 12-myristate 13-acetate diester
12-O-hexadecanoylphorbol-13-acetate
PHORBOL-12-MYRISTATE-13-ACETATE = PMA