4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
- CAS No.
- 63597-44-4
- Chemical Name:
- 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
- Synonyms
- 4α-TPA;4α-pma;4α-TPA;alpha-TPA;4ALPHA-PMA;4ALPHA-TPA;4-alpha-PMA, 4-alpha-TPA;4α-Phorbol 12-myristate 13-acetate;4a-Phorbol 12-Myristate 13-Acetate;4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
- CBNumber:
- CB4748443
- Molecular Formula:
- C36H56O8
- Molecular Weight:
- 616.83
- MOL File:
- 63597-44-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:03:08
| storage temp. | -20°C |
|---|---|
| solubility | H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media. |
| form | solid |
| color | white |
| Sensitive | Light Sensitive |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H351 |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| WGK Germany | 3 |
| F | 10-21 |
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Chemical Properties,Uses,Production
Uses
4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.
Biochem/physiol Actions
Negative control for phorbol ester activation of protein kinase C.
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Suppliers
Global( 27)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 15002134094 | China | 28118 | 58 | Inquiry |
| Shanghai Yingxin laboratory equipment Co., Ltd | 021-021-59178156 15300768757 | China | 10678 | 58 | Inquiry |
| Shanghai Guchen Biotechnology Co., LTD | 021-34675735 19147740836 | China | 9849 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9708 | 58 | Inquiry |
| LKT Laboratories, Inc. | 651 644 8424 | United States | 2164 | 64 | Inquiry |
| MP Biomedicals, Inc. | 949 833 2500 | United States | 6566 | 81 | Inquiry |
| Promega Corporation | 1 800 356-9526 | United States | 612 | 82 | Inquiry |
63597-44-4(4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE)Related Search:
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4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL
4α-pma
4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
(1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate
4α-TPA
4-alpha-Phorbol 12-Myristate 13-Acetate >99%
4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate
4-alpha-PMA, 4-alpha-TPA
4ALPHA-12-O-TETRADECANOYLPHORBOL 13-ACETATE
4-ALPHA-12-TETRADECANOYL PHORBOL 13-ACETATE
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
4ALPHA-PMA
4ALPHA-TPA
Tetradecanoic acid,(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester
alpha-TPA
4α-Phorbol 12-myristate 13-acetate
4a-Phorbol 12-Myristate 13-Acetate
4α-TPA
63597-44-4
Serine/Threonine Kinase Activators
Protein Kinase C (PKC)
Kinase/Phosphatase Biology
Cell Signaling and Neuroscience
Cell Biology
BioChemical
metabolite