PHORBOL 12,13-DIACETATE

PHORBOL 12,13-DIACETATE Structure
CAS No.
24928-15-2
Chemical Name:
PHORBOL 12,13-DIACETATE
Synonyms
PDA;PHORBOL-DIACETATE;phorbol11,12-diacetate;phorbol10,11-diacetate;PHORBOL 12,13-DIACETATE;Phorbol 12,13-Diacetate >99%;PHORBOL 12,13-DIACETATE, 4BETA;l)-1,1,6,8-alpha-tetramethyl-,9,9a-diacetate,(+);8,9,9a-decahydro-4a-beta,7b-alpha,9-beta,9a-alpha-tetrahydroxy-3-(hydroxymethy;5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-alpha,16-beta,4,4a,7a-alpha,7b,
CBNumber:
CB2702142
Molecular Formula:
C24H32O8
Molecular Weight:
448.51
MOL File:
24928-15-2.mol
Modify Date:
2023/4/23 13:52:06

PHORBOL 12,13-DIACETATE Properties

Boiling point 477.23°C (rough estimate)
Density 1.1793 (rough estimate)
refractive index 1.4480 (estimate)
storage temp. −20°C
solubility H2O: soluble
form powder
color white
BRN 2317312

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300+H310+H330-H315-H319-H335
Precautionary statements  P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310-P305+P351+P338
Hazard Codes  T+
Risk Statements  26/27/28-36/37/38
Safety Statements  26-27-36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  GZ0651000
8-10
HazardClass  6.1(a)
PackingGroup  II
HS Code  2915290000

PHORBOL 12,13-DIACETATE Chemical Properties,Uses,Production

Uses

Phorbol 12,13-diacetate may be used to stimulate protein kinase C (PKC) for phosphorylation of retinal proteins.

General Description

Phorbol ester with enhanced hydrophilicity.

Biochem/physiol Actions

Phorbol 12,13-diacetate (PDA) serves as a protein kinase C (PKC). It induces arrest in translocation in rod photoreceptors. PDA facilitates PKC in regulating airway contractility by inducing transient relaxation after a sustained contraction of the human isolated bronchus. PDA improves the synaptic transmission of nociceptive parabrachioamygdaloid (PBA) input onto neurons of the capsular central amygdaloid (CeAC) nucleus via activating PKC and extracellular-regulated kinase (ERK).

PHORBOL 12,13-DIACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

PHORBOL 12,13-DIACETATE Suppliers

Global( 18)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Spectrum Chemicals & Laboratory Products 310 516 8000 United States 6706 77 Inquiry
MP Biomedicals, Inc. 949 833 2500 United States 6566 81 Inquiry
Wako Pure Chemical Industries, Ltd. +81 6 6203 3741 Japan 6828 80 Inquiry
Alexis Corporation +41 61 926 8989 Switzerland 3599 74 Inquiry
CHEMICAL LAND21 82- 2 -783 - 8063 South Korea 6315 74 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6373 71 Inquiry
3B Scientific Corporation 847.281.9822 United States 6744 47 Inquiry
Advance Scientific & Chemical (954) 327-0900 United States 6434 71 Inquiry
SIGMA-RBI 800 736 3690 (Orders) Switzerland 6913 91 Inquiry
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 China 96815 76 Inquiry
Phorbol 12,13-Diacetate >99% (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl diacetate PHORBOL 12,13-DIACETATE PHORBOL 12,13-DIACETATE, 4BETA PDA 5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-alpha,16-beta,4,4a,7a-alpha,7b, 8,9,9a-decahydro-4a-beta,7b-alpha,9-beta,9a-alpha-tetrahydroxy-3-(hydroxymethy l)-1,1,6,8-alpha-tetramethyl-,9,9a-diacetate,(+) phorbol10,11-diacetate phorbol11,12-diacetate PHORBOL-DIACETATE (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-5-oxo-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulene-4aβ,7bα,9β,9aα-tetrol 9,9a-diacetate 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9,9a-bis(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)- 24928-15-2 Cell Signaling and Neuroscience Cell Biology BioChemical Kinase/Phosphatase Biology Protein Kinase C (PKC) Serine/Threonine Kinase Activators Activator