3,3',5-Triiodo-L-thyronine

3,3',5-Triiodo-L-thyronine Properties

Melting point	234-238 °C(lit.)
alpha	23 º (c=2 in ethanol)
Boiling point	232°C (rough estimate)
Density	2.2155 (estimate)
Flash point	9°C
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Very Slightly)
form	powder
pka	pKa 8.5 (Uncertain);8.4 (Uncertain);8.45 (Uncertain)
color	Off-white to pale yellow
optical activity	[α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
Water Solubility	Insoluble in water, ethanol and propylene glycol. Soluble in dilute alkalies.
Sensitive	Light Sensitive
Merck	14,5510
BRN	2710227
Stability	Light Sensitive
CAS DataBase Reference	6893-02-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Danger

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xn,Xi,T,F

Risk Statements

20/21/22-36/37/38-39/23/24/25-23/24/25-11

Safety Statements

36-26-36/37/39-45-36/37-16

RIDADR

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany

3

RTECS

AY6750000

F

8

HS Code

29225090

Toxicity

LDLo oral in rat: 7500mg/kg

NFPA 704

	1
2		1

3,3',5-Triiodo-L-thyronine price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	T2877	3,3′,5-Triiodo-L-thyronine ≥95% (HPLC), powder	6893-02-3	100MG	₹6246.03	2022-06-14	Buy
Sigma-Aldrich(India)	T2877	3,3′,5-Triiodo-L-thyronine ≥95% (HPLC), powder	6893-02-3	250MG	₹13585.38	2022-06-14	Buy
Sigma-Aldrich(India)	T2877	3,3′,5-Triiodo-L-thyronine ≥95% (HPLC), powder	6893-02-3	500MG	₹20296.88	2022-06-14	Buy
Sigma-Aldrich(India)	T2877	3,3′,5-Triiodo-L-thyronine ≥95% (HPLC), powder	6893-02-3	1G	₹30667.23	2022-06-14	Buy
Sigma-Aldrich(India)	T2877	3,3′,5-Triiodo-L-thyronine ≥95% (HPLC), powder	6893-02-3	5G	₹131826.85	2022-06-14	Buy

Product number	Packaging	Price	Buy
T2877	100MG	₹6246.03	Buy
T2877	250MG	₹13585.38	Buy
T2877	500MG	₹20296.88	Buy
T2877	1G	₹30667.23	Buy
T2877	5G	₹131826.85	Buy

3,3',5-Triiodo-L-thyronine Chemical Properties,Uses,Production

Description

Crystalline T3 (liothyronine sodium, Cytomel) has a rapid onset and short duration of action. It is the therapy of choice when it is desirable to have rapid onset or cessation of activity, such as in patients with heart disease.

Chemical Properties

Off-White Solid

Uses

T3 or 3,3',5-Triiodo-L-thyronine is a thyroid hormone involved with many physiological processes in the human body including growth and development, metabolism, body temperature and heart rate. Free and total T3 serum levels are measured by LC-MS/MS for determination of hyperthyroidism caused by excess T3. This Certified Spiking Solution? is suitable for use as a starting material in preparation of linearity standards, calibrators, and controls for thyroid hormone testing methods by LC-MS/MS.

Application

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.
3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.

Definition

ChEBI: An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxi e in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Biological Activity

3,3′,5′-Triiodo-L-thyronine (T3) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

Purification Methods

Likely impurities are as in thyroxine. Purify it by dissolving in dilute NH3 at ~20o, then crystallise it by addition of dilute acetic acid to pH 6. Alternatively 35g are purified by dissolving it in a mixture of EtOH (250mL) and 2N NaOH (100mL), then hot 2N HCl is added to the boiling solution until the pH is 4-5. After cooling for a few hours, the solid is filtered off and dried in a vacuum [m 233-235o(dec)]. [Chambers et al. J Chem Soc 2433 1949, Beilstein 14 III 1566, 14 IV 2373.]

3,3',5-Triiodo-L-thyronine Preparation Products And Raw materials

Raw materials

iodine 3,5-Diiodo-L-thyronine

Preparation Products

3,3',5-Triiodo-L-thyronine Suppliers

Global( 274)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
GLP Pharma Standards	+91 9866074638	Hyderabad, India	1644	58	Inquiry
Rakshit Group of Companies (Rakshit Drugs Pvt Ltd)	+91-4023810385 +91-9246228579	Telangana, India	36	58	Inquiry
Molsyns Research	+91-9586858886 +91-9586858886	Gujarat, India	418	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Sisco Research Laboratories Pvt. Ltd.	+91-22-4268 5800	Mumbai, India	4317	58	Inquiry
Triveni chemicals	08048762458	New Delhi, India	6093	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Heartland Pharmacy (OPC) Private Limited	07942564104	Uttar Pradesh, India	3	58	Inquiry
Bonassama District Labo	09788377780	Karnataka, India	5	58	Inquiry

Supplier	Advantage
GLP Pharma Standards	58
Rakshit Group of Companies (Rakshit Drugs Pvt Ltd)	58
Molsyns Research	58
TCI Chemicals (India) Pvt. Ltd.	58
Sisco Research Laboratories Pvt. Ltd.	58
Triveni chemicals	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Heartland Pharmacy (OPC) Private Limited	58
Bonassama District Labo	58

3,3',5-Triiodo-L-thyronine Spectrum

3,3',5-Triiodo-L-thyronine(6893-02-3)¹HNMR 3,3',5-Triiodo-L-thyronine(6893-02-3)¹³CNMR 3,3',5-Triiodo-L-thyronine(6893-02-3)IR1 3,3',5-Triiodo-L-thyronine(6893-02-3)Raman

6893-02-3(3,3',5-Triiodo-L-thyronine)Related Search:

Liothyronine sodium REVERSE T3 Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED 3,5-Diiodo-L-thyronine 3,3',5-TRIIODOTHYROPROPIONIC ACID

3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID N-ForMyl Thyroxine 3,5,3',5'-Tetraiodo Thyroaldehyde 3-IODO-L-TYROSINE 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID

4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetaMide 3,5,3',5'-Tetraiodo Thyrolactic Acid 3,3',5-TRIIODOTHYROACETIC ACID 3,5-DIIODOTHYROACETIC ACID Levothyroxine EP Impurity B

Sodium levothyroxine N-Acetyl L-Thyroxine L-Thyroxine-13C9,15N

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L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo- (9CI) NSC 80203 Thyronine, 3,3',5-triiodo-, L- (6CI) IODOTHYRONINE 3,3,5-TRIIODO-L -THYRONINE 95-98% FREE ACID CRYSTALLINE 3,3μ,5 Triiodothyronine (T3) 3,3μ,5-Triiodo-L-thyronine, Liothyronine, T3, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine Liothyronine, T3, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, L l-liothyr 3,3′,5-Triiodo-L-thyronine,O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T3 Liothyronine (250 mg) Liothyronine (250 mg)M0D3380.993mg/mg(dr) 3,5,3′-Triiodo-L-thyronine 3,5,3′-Triiodo-L-thyronine 3,3',5-triiodo-L-thyronine 2 (S)-2-Amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic acid L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo Three triiodothyronine 3,3′,5-Triiodo-L-thyronine, >=99% 3,3',5-Triiodo-L-thyronine 3,3,5-Triiodo-L-thyronine≥ 99% (HPLC: Anhydrous basis) 3,3’,5-triiodothyronine 3,5,3’-triiodothyronine 3’,5-triiodo-l-thyronin 4-(3-iodo-4-hydroxyphenoxy)-3,5-diiodophenylalanine 5-diiodophenyl)-3-(4-(4-hydroxy-3-iodophenoxy)-l-alanin l-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine l-liothyronine lyothyronine o-(4-hydroxy-3-iodophenyl)-3,5-diiodo-l-tyrosin t3(aminoacid) t3(hormone) tresitope 3,3',5'-TRIIODO-L-THYRONINE L-3,3,5-Triiodothyronine, Free Acid 2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-propanoic acid Alanine, 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-, L- (8CI) triothyrone β-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine L-3,3',5'-TRIIODOTHYRONINE LiothyronineSodiumB.P. 5-Triiodothyronine 3,3′,5-Triiodo-L-thyronine (T3) solution Levothyroxine Impurity 1（Levothyroxine EP Impurity A） Triiodo-thyroninum (3,3,5-triiodo-L-thyrnine) T3) (Solution) Triiodothyronine (T3) (solution) 3,3',5-Triiodo-L-thyronine > O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine USP/EP/BP order fat burners cytomel raw T3 powder l-liothyronine(T3) Thyro3 3,3,5 - TRIIODO - L - FREEACIDCRYSTALLINE THYRONINE95-98% L-3-iodothyronine Thyronine, 3, 3 ', 5 - triiodo -, L - (ci) 3,3,5-TRIIODOChemicalbook-L-THYRONINE95-98%FREEACIDCRYSTALLINE TIANFU CHEM 6893-02-3 O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine 3,3,5-Triiodo-L-Thyronine extrapure, 95%