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L-Malic acid

L-Malic acid Structure
CAS No.
97-67-6
Chemical Name:
L-Malic acid
Synonyms
L-MALIC ACID;L-Malic;(2S)-2-hydroxybutanedioic acid;L-Mailcacid;HYDROXYBUTANEDIOIC ACID;L-Gydroxybutanedioicacid;apple acid;pinguosuan;(S)-(-)-MALIC ACID;-(-)-MaL
CBNumber:
CB0493594
Molecular Formula:
C4H6O5
Molecular Weight:
134.09
MOL File:
97-67-6.mol
MSDS File:
SDS
Modify Date:
2024/8/19 17:35:41
Request For Quotation

L-Malic acid Properties

Melting point 101-103 °C (lit.)
Boiling point 167.16°C (rough estimate)
alpha -2 º (c=8.5, H2O)
Density 1.60
vapor pressure 0Pa at 25℃
FEMA 2655 | L-MALIC ACID
refractive index -6.5 ° (C=10, Acetone)
Flash point 220 °C
storage temp. Store below +30°C.
solubility H2O: 0.5 M at 20 °C, clear, colorless
form Powder
Specific Gravity 1.595 (20/4℃)
color White
PH 2.2 (10g/l, H2O, 20℃)
pka (1) 3.46, (2) 5.10(at 25℃)
Odor odorless
Odor Type odorless
optical activity [α]20/D 30±2°, c = 5.5% in pyridine
Water Solubility soluble
JECFA Number 619
Merck 14,5707
BRN 1723541
InChIKey BJEPYKJPYRNKOW-REOHCLBHSA-N
LogP -1.68
CAS DataBase Reference 97-67-6(CAS DataBase Reference)
NIST Chemistry Reference Butanedioic acid, hydroxy-, (s)-(97-67-6)
EPA Substance Registry System Butanedioic acid, 2-hydroxy-, (2S)- (97-67-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  ON7175000
TSCA  Yes
HS Code  29181980
NFPA 704
0
2 0

L-Malic acid price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) M7397 L-(−)-Malic acid suitable for cell culture, BioReagent, suitable for insect cell culture 97-67-6 25G ₹6419.23 2022-06-14 Buy
Sigma-Aldrich(India) M7397 L-(−)-Malic acid suitable for cell culture, BioReagent, suitable for insect cell culture 97-67-6 100G ₹14689.53 2022-06-14 Buy
Sigma-Aldrich(India) M7397 L-(−)-Malic acid suitable for cell culture, BioReagent, suitable for insect cell culture 97-67-6 500G ₹48485.18 2022-06-14 Buy
Sigma-Aldrich(India) M6413 L-(−)-Malic acid BioXtra, ≥95% 97-67-6 25G ₹5315.08 2022-06-14 Buy
Sigma-Aldrich(India) M6413 L-(−)-Malic acid BioXtra, ≥95% 97-67-6 100G ₹15165.83 2022-06-14 Buy
Product number Packaging Price Buy
M7397 25G ₹6419.23 Buy
M7397 100G ₹14689.53 Buy
M7397 500G ₹48485.18 Buy
M6413 25G ₹5315.08 Buy
M6413 100G ₹15165.83 Buy

L-Malic acid Chemical Properties,Uses,Production

Description

L-Malic acid is nearly odorless (sometimes a faint, acrid odor) with a tart, acidic taste. It is nonpungent. May be prepared by hydration of maleic acid; by fermentation from sugars.

Chemical Properties

clear colourless solution

Occurrence

Occurs in maple sap, apple, melon, papaya, beer, grape wine, cocoa, sake, kiwifruit and chicory root.

Uses

L-Malic acid is used as a food additive, Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B.

Definition

ChEBI: An optically active form of malic acid having (S)-configuration.

Preparation

L-Malic acid can be prepared by hydration of maleic acid; by fermentation from sugar.

General Description

L-Malic acid is an organic acid that is commonly found in wine. It plays an important role in wine microbiological stability.

Biochem/physiol Actions

L-Malic acid is a part of cellular metabolism. Its application is recognized in pharmaceutics. It is useful in the treatment of hepatic malfunctioning, effective against hyper-ammonemia. It is used as a part of amino acid infusion. L-Malic acid also serves as a nanomedicine in the treatment of brain neurological disorders. A TCA (Krebs cycle) intermediate and partner in the malic acid aspartate shuttle.

Purification Methods

Crystallise S-malic acid (charcoal) from ethyl acetate/pet ether (b 55-56o), keeping the temperature below 65o. Or dissolve it by refluxing in fifteen parts of anhydrous diethyl ether, decant, concentrate to one-third volume and crystallise it at 0o, repeatedly to constant melting point. [Beilstein 3 IV 1123.]

L-Malic acid Preparation Products And Raw materials

Raw materials

Calcium carbonate Disodium fumarate Poly(acrylic acid) (2S)-1-(3-Acetylthio-2-methyl-1-oxopropyl)-L-proline

Preparation Products

Fluorescent Brightener 135 (S)-(+)-3-Hydroxytetrahydrofuran (-)-(1S,4R)-4-AMINOCYCLOPENT-2-ENECARBOXYLIC ACID (R)-(-)-3-Quinuclidinol (S)-1-Benzyl-3-pyrrolidinol
(S)-3-Hydroxypyrrolidine hydrochloride Diethyl malate (R)-3-Quinuclidinol hydrochloride Coumalic acid CHLOROSUCCINIC ACID
2,5-Pyrrolidinedione, 3-(acetyloxy)-, (3S)- Butanedioic acid, 2-hydroxy-, 1-(phenylmethyl) ester, (2S)- Cabozantinib Malate
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L-Malic acid Suppliers

Global( 710)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
HRV Global Life Sciences +91-9820219686 +91-9820219686 Telangana, India 379 58 Inquiry
Clearsynth Labs 91-22-45045900 Maharashtra, India 3889 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Avanscure Lifesciences Private Limited 09599609443 Haryana, India 66 58 Inquiry
Padmavati Pharmachem 08046031834 Mumbai, India 54 58 Inquiry
Nandlal Bankatlal Private Limited 08047631198 Mumbai, India 30 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
Supplier Advantage
JSK Chemicals 58
HRV Global Life Sciences 58
Clearsynth Labs 58
CHEMSWORTH 30
CLEARSYNTH LABS LTD. 58
Avanscure Lifesciences Private Limited 58
Padmavati Pharmachem 58
Nandlal Bankatlal Private Limited 58
TCI Chemicals (India) Pvt. Ltd. 58
Alfa Aesar 58

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L(-)-Malic acid, 30 wt% aqueous solution Butanedioic acid, hydroxy-, (2S)- L-MALIC ACID L L-LYSINEMONOHCL L-MALIC ACID / (S)-(-)-HYDROXYSUCCINIC ACID (S)-(-)-2-Hydroxysuccinic acid, L-Hydroxybutanedioic acid S-2-Hydroxybutanedioic acid )-Malic ac L-()-Malic ac L(-)-Malic acid, 99% 25GR L-2-Hydroxybutanedioic acid L-(-)-MALIC ACID FOR RESOLUTION OF RACEM L-(-)-Malic acid 95-100% (enzyMatic) L-(-)-Malic acid 97%, optical purity ee: 99% (GLC) L-(-)-Malic acid ReagentPlus(R), >=99% L-(-)-Malic Acid, 97+% L-(-)-Malicacid,98+% L-(-)-Malicacid,99% L-(-)-ALIC ACID, AQUEOUS SOLUTION L-(-)-Malic acid Vetec(TM) reagent grade, 97% malic acid ,Hydrozybutanedioic acid (S)-(-)-2-Hydroxysuccinic acid L-Hydroxybutanedioic acid Apple acid L-(-)-Apple Acid (S)-(-)-HYDROXYSUCCINIC ACID (S)-HYDROXYSUCCINIC ACID (S)-HYDROXYBUTANEDIOIC ACID (S)-2-HYDROXYBUTANEDICARBOXYLIC ACID S(-)-2-HYDROXYSUCCINIC ACID NATURAL APPLE ACID L-HYDROXYSUCCINIC ACID L-HYDROXYBUTANEDIOIC ACID L-(-)-APPLE ACID L-APPLE ACID L(-)-MALATE (-)-L-MALIC ACID L-(-)-MALIC ACID MALIC ACID, L-(-)- 2-HYDROXYSYCCINIC ACID 1-HYDROXYSUCCINIC ACID L-Maleic Acid L(+-)MALIC ACID FREE ACID INSECT CELL*CU LTURE TESTE L-MALIC ACID FREE ACID CRYSTALLINE L(-)MALIC ACID FREE ACID PLANT CELL*CULT URE TESTED L (-) MALIC ACID SIGMAULTRA L-MALIC ACID 99+% FCC L-MALIC ACID BIOTECH GRADE 99.5% Butanedioicacid,hydroxy-,(S)- hydroxy-,(S)-Butanedioicacid l-(ii)-malicacid L-(-)-MalicAcid> CultureSure L(-)-Malic Acid, Animal-derived-free -(-)-MaL (S)-malicaci L-(-)-Malic Acid ISO 9001：2015 REACH N'1-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide L-malic acidQ: What is L-malic acid Q: What is the CAS Number of L-malic acid Q: What is the storage condition of L-malic acid Q: What are the applications of L-malic acid L-(-)-Malic acid, CP Butanedioic acid, 2-hydroxy-, (2S)- L-Gydroxybutanedioicacid