Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >(S)-(+)-3-Hydroxytetrahydrofuran

(S)-(+)-3-Hydroxytetrahydrofuran

(S)-(+)-3-Hydroxytetrahydrofuran Structure
CAS No.
86087-23-2
Chemical Name:
(S)-(+)-3-Hydroxytetrahydrofuran
Synonyms
(S)-TETRAHYDROFURAN-3-OL;(S)-3-HYDROXYTETRAHYDROFURAN;(3S)-oxolan-3-ol;(3S)-Tetrahydrofuran-3-ol;(S)-(-)-3-HYDROXY TETRAHYDRO FURAN;Oxolane-3β-ol;(S)-Hydroxy THF;Afatinib intermediate;S-3- Hydroxytetrafuran;Afatinib intermediate B
CBNumber:
CB2142463
Molecular Formula:
C4H8O2
Molecular Weight:
88.11
MOL File:
86087-23-2.mol
MSDS File:
SDS
Modify Date:
2024/7/2 14:09:54
Request For Quotation

(S)-(+)-3-Hydroxytetrahydrofuran Properties

alpha 18.5 º (c=2 MeOH)
Boiling point 80 °C/15 mmHg (lit.)
Density 1.103 g/mL at 25 °C (lit.)
vapor pressure 47Pa at 25℃
refractive index n20/D 1.45(lit.)
Flash point 175 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Methanol (Slightly)
pka 14.49±0.20(Predicted)
form Liquid
color Clear colorless to pale yellow
Specific Gravity 1.11
optical activity [α]20/D +17.5°, c = 2.4 in methanol
Water Solubility soluble
BRN 4652609
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey XDPCNPCKDGQBAN-BYPYZUCNSA-N
LogP -0.784 at 22℃ and pH6.8
Surface tension 72mN/m at 1g/L and 25℃
CAS DataBase Reference 86087-23-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
RIDADR  NA 1993 / PGIII
WGK Germany  3
HS Code  29321900
NFPA 704
2
2 0

(S)-(+)-3-Hydroxytetrahydrofuran price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 296686 (S)-(+)-3-Hydroxytetrahydrofuran 99% 86087-23-2 5G ₹15501.4 2022-06-14 Buy
Sigma-Aldrich(India) 296686 (S)-(+)-3-Hydroxytetrahydrofuran 99% 86087-23-2 25G ₹21909.8 2022-06-14 Buy
ALFA India ALF-H56476-14 (S)-(+)-3-Hydroxytetrahydrofuran, 98% 86087-23-2 25g ₹20657 2022-05-26 Buy
TCI Chemicals (India) T1716 (S)-3-Hydroxytetrahydrofuran min. 98.0 % 86087-23-2 1G ₹2300 2022-05-26 Buy
TCI Chemicals (India) T1716 (S)-3-Hydroxytetrahydrofuran min. 98.0 % 86087-23-2 5G ₹5000 2022-05-26 Buy
Product number Packaging Price Buy
296686 5G ₹15501.4 Buy
296686 25G ₹21909.8 Buy
ALF-H56476-14 25g ₹20657 Buy
T1716 1G ₹2300 Buy
T1716 5G ₹5000 Buy

(S)-(+)-3-Hydroxytetrahydrofuran Chemical Properties,Uses,Production

Description

(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.

Chemical Properties

Colourless Liquid

Uses

(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.

Uses

(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.

Synthesis

(S)-(+)-3-Hydroxytetrahydrofuran was prepared from the reaction of (S)-1,2,4-butanetriol under hydrochloric acid modified montmorillonite catalyst. The steps were as follows：To the heatable reactor (with stirring device), 100g (S)-1,2,4-butanetriol, 200mL toluene, 15g hydrochloric acid modified montmorillonite catalyst prepared in were added successively. The reaction was stopped after 4 h at 110°C. After the reaction is finished, it is naturally cooled to room temperature, and the obtained material is filtered to recover the catalyst. After collecting the filtrate, the remaining solvent and by-product water in the filtrate are distilled off to obtain (S)-3-hydroxytetrahydrofuran crude product. Quantitative analysis was carried out by gas chromatography, and the yield was 96.8%. Finally, the (S)-3-hydroxytetrahydrofuran was obtained by rectification and purification.S)-(+)-3-Hydroxytetrahydrofuran synthesis

(S)-(+)-3-Hydroxytetrahydrofuran Preparation Products And Raw materials

Raw materials

L-Malic acid p-Toluenesulfonic acid Ethanol Toluene Tetrahydrofuran
Ethyl acetate Lithium Aluminum Hydride Methanol
chevron_left

1of2

chevron_right

Preparation Products

(R)-(-)-3-Hydroxytetrahydrofuran (S)-3-P-MESYLOXYTETRAHYDROFURAN (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

(S)-(+)-3-Hydroxytetrahydrofuran Suppliers

Global( 722)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
BTC pharm India +918790379245 AndhraPradesh, India 1269 58 Inquiry
Urantiis Pharmaceuticals Private Limited +918790703567 AndhraPradesh, India 80 58 Inquiry
EPOCH LABS +91-7702174901 +91-9515109812 Hyderabad, India 68 58 Inquiry
Nios laboratories +91-9014349341 +91-8686466680 Hyderabad, India 59 58 Inquiry
BNR LABORATORIES +91-9490673489 +91-9490673489 Telangana, India 25 58 Inquiry
Aastrid Life Sciences Private Limited +91-91-22-40072626 +91-7304494278 Mumbai, India 95 58 Inquiry
Vijayasri Organics Private Limited +91-9848990113 +91-9848990113 Telangana, India 43 58 Inquiry
Vision Drugs Pvt Ltd +91 9948045450 Telangana, India 65 58 Inquiry
Bhausa Life Sciences +91-8154986830 +91-8154986830 Gujarat, India 201 58 Inquiry
R SCIENTIFIC +919000280374 Hyderabad, India 143 58 Inquiry
Supplier Advantage
BTC pharm India 58
Urantiis Pharmaceuticals Private Limited 58
EPOCH LABS 58
Nios laboratories 58
BNR LABORATORIES 58
Aastrid Life Sciences Private Limited 58
Vijayasri Organics Private Limited 58
Vision Drugs Pvt Ltd 58
Bhausa Life Sciences 58
R SCIENTIFIC 58

Related articles

(S)-(+)-3-Hydroxytetrahydrofuran Spectrum

(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)MS(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)1HNMR(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)13CNMR(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)IR1(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)Raman

86087-23-2((S)-(+)-3-Hydroxytetrahydrofuran)Related Search:

Tetrahydrofuran 2-Methyltetrahydrofuran 3-(S)-HYDROXY TETRAHYDROFURAN 3-HYDROXYTETRAHYDROFURAN 99%,3-HYDROXYTETRAHYDROFURAN (RS)-3-Hydroxytetrahydrofuran
POLY(TETRAHYDROFURAN) STANDARD 15000 (R)-(+)-3-HYDROXYTETRAHYDROFURAN-2-ONE α-D-erythro-Pentofuranose-2-deoxy-2,2-difluoro-3,5-dibenzoate (S)-4-HYDROXYTETRAHYDROFURAN-2-ONE,4(S)-Hydroxytetrahydrofuran-2-ONE 3-HYDROXYTETRAHYDROFURAN-2-ONE,2-Hydroxytetrahydrofuran-2-one
(R)-(-)-3-HYDROXYTETRAHYDROFURAN,(R)-3-HYDROXYTETRAHYDROFURAN ((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate (S)-(+)-3-HYDROXYTETRAHYDROFURAN-D4 (3R)-3β,4α-Bis(3-methoxy-4-hydroxybenzyl)-3-hydroxytetrahydrofuran-2-one (2R, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL
(2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL (2S, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL 4-HYDROXYTETRAHYDROFURAN-2-METHANOL
chevron_left

1of4

chevron_right
(S)-(+)-TETRAHYDRO-3-FURANOL (S)-(+)-3-HYDROXY TETAHYDRO FURAN (2S)-1,4-Epoxy-2-hydroxybutane, (3S)-Tetrahydrofuran-3-ol, (3S)-Oxolan-3-ol Afatinib intermediate B (S)-(+)-3-Hydroxytetrahydrofuran, ee: 95% Afatinib intermediate (S)-(+)-3-HydroxytetrahydrofuranZ (S)-(+)-3-Hydroxytetrahydrofuran 99% (S)-(+)-3-HYDROXYTETRAHYDROFURAN (S)-(+)-3-HYDROXYTETRAHYDROFURANE 3-FURANOL, TETRAHYDRO-, (S) (S)-(+)-3-HYDROXYTETRAHYDROFURAN, 99% (9 S-(+)-3-HYDROXYTETRAHYDROFURAN 98+% (S)-(+)-3-HYDOXY TETAHYDRO TETRAHYDRO FURAN (S)-3-Hydroxyterthydrofurane S-HYDROXYTETRAHYDROFURAN S-(+)-3-Hydroxytetrahydofuran (3S)-Tetrahydrofuran-3β-ol Oxolane-3β-ol (S)-(+)-3-Hydroxytetrahydrofuran,99% (S)-(+)-tetrahyro-3-furanol (S)-(+)-3-Hydroxytetrahydrofuran ,98% [ee:95%] (2S)-2-Hydroxy-1,4-epoxybutane (3S)-3-Hydroxytetrahydrofuran (S)-(+)-3-Hydroxytetrahydrofuran, 98% colorless liquid (S)-(+)-3-Hydroxytetrahydrofuran, 98%, ee: 95% (3S)-(+)-3-Hydroxytetrahydrofuran 97+% (S)-(+)-3-HYDROXYTETRAHYDROFURAN, (9 (S)-(+)-3-Hydroxy-1,2,3,4-tetrahydrofuran S-3-hydroxytetrahydrofur (S)-3-hydroxytetyrahydrofurane S-3- Hydroxytetrafuran 3-Furanol, tetrahydro-, (3S)- (S)-(+)-3-HYDROXYTETRAHYDROFURAN (CAS NO.86087-23-2) (S)-Hydroxy THF (3S)-Tetrahydrofuran-3-ol,(3S)-Oxolan-3-ol (+)-3-Hydroxy-1,2,3,4-Tetrahydrofuran (S)-TETRAHYDROFURAN-3-OL (S)-(-)-3-HYDROXY TETRAHYDRO FURAN (3S)-oxolan-3-ol (S)-3-HYDROXYTETRAHYDROFURAN (3S)-Tetrahydrofuran-3-ol Empagliflozin Impurity 100 (S)-3-hydroxytetyrahydrofuran (+)-3-Hydroxytetrahydrofuran 2,4-Dichlorobenzyl Alcohol Impurity 10 86087-23-2 86087-23-3 ALCOHOL Simple Alcohols (Chiral) Chiral Building Blocks Heterocyclic Building Blocks Furans Asymmetric Synthesis Afatinib intermediate Chiral Building Blocks Simple Alcohols (Chiral) Synthetic Organic Chemistry